Navigation Links
Alzheimer's imaging study identifies changes in brain's white matter
Date:6/28/2010

LEXINGTON, Ky. (June 28, 2010) − Scientists at the University of Kentucky's College of Medicine have identified changes in the brains of normal individuals at high risk for Alzheimer's disease that could prove important for early detection of the disease.

The research, led by Brian Gold, associate professor of anatomy and neurobiology, focused on the brain's white matter, which forms the majority of deep parts of the brain and consists primarily of myelinated nerve cell processes, or axons. These myelinated axons serve to connect the brain's gray matter regions, which contain nerve cell bodies.

"The brain's white matter can be thought of as a set of telephone wires which enable communication between gray matter 'thinking regions'," Gold said.

Previous studies have demonstrated decline in both gray and white matter tissue types in individuals with Alzheimer's. In the present study, the authors sought to determine which of these changes are present in normal seniors at high risk for Alzheimer's disease, a likely target group for emerging interventions.

The high-risk group consisted of individuals whom have both genetic and family risk factors for Alzheimer's disease but do not yet show cognitive changes. The low-risk control group consisted of individuals who had neither risk factor but were similar to the high-risk group in terms of age, education level and cognitive functioning.

The study used several magnetic resonance imaging (MRI) techniques to assess the integrity of gray matter and white matter brain tissue in the high and low risk groups. In particular, a recently developed form of MRI called diffusion tensor imaging (DTI) was used to assess the integrity of the brain's white matter. This technique allows for assessment of the microstructural integrity of axons and their surrounding myelin.

Results indicated that the two groups did not differ in the tissue volumes of several gray matter regions know to contribute to memory function. However, the high-risk group showed decreased integrity in white matter tracts that inter-connect gray matter regions involved in memory function. Both the axonal and myelin integrity of these white matter tracts were reduced.

These data suggest that changes in white matter connections may be among the earliest brain changes in Alzheimer's disease, which may prove important for early detection by non-invasive imaging. In addition, the findings may have implications for the development of new preventative treatment interventions in Alzheimer's disease, which could attempt to protect axon and myelin integrity in seniors at risk for this neurological disorder.


'/>"/>

Contact: Keith Hautala
keith.hautala@uky.edu
859-257-1754
University of Kentucky
Source:Eurekalert

Related medicine news :

1. Volumetrics Medical Imaging, LLC and Medison Co., Ltd. Announce Technology License and Settlement of Patent Litigation
2. Leading Radiologist and Imaging Specialist Joins Children's National Medical Center
3. SNMs 2010 Annual Meeting reveals latest developments in molecular imaging and nuclear medicine
4. SNM 2010 image of the year: Molecular imaging shows parathyroid disease in greater detail
5. UltraLinq Healthcare Solutions and Advanced Imaging Consultants Partner to Provide an Anytime, Anywhere Image Management Solution to the Mobile Market
6. Molecular imaging detects recurrent prostate cancer
7. Accelarad Partners with Visage Imaging, Inc. To Enhance Its Next Generation Medical Image Exchange Solution
8. Molecular imaging and CT colonography team up to bring comfort to patients
9. Simple change results in fewer unnecessary imaging exams for patients
10. Salt Lake City proclaims Molecular Imaging Days during SNMs Annual Meeting in June
11. A useful tool to detect in vivo angiogenesis in IBD patients: Narrow-band imaging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of ... its next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his ... July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming ...
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Yisrayl Hawkins, Pastor ... that explains one of the most popular and least understood books in the Holy ... and puzzling descriptions that have baffled scholars for centuries. Many have tossed it off ...
(Date:10/12/2017)... ... October 12, 2017 , ... First ... compliance program management, will showcase a range of technology and learning solutions at ... (NCAL) Convention and Expo to be held October 14–18, 2017 at the Mandalay ...
(Date:10/12/2017)... Bethesda, MD (PRWEB) , ... October 12, 2017 , ... ... Award of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s ... 4 – 8. , In honor of Morris F. Collen, a pioneer in the ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017 /PRNewswire/ ... and OptiMed Specialty Pharmacy of Kalamazoo, Mich. ... a strategic hub service that expedites and streamlines patient ... spirometer, Spiro PD 2.0, and wellness management services.  ... a medical device used to measure lung function for ...
(Date:9/13/2017)... has been named the official orthopedic and sports medicine ... 2018 College Football Playoff (CFP) National Championship to be played ... Atlanta, Georgia . OrthoAtlanta is proud to be ... many activities leading up to, and including the national championship ... OrthoAtlanta serves ...
(Date:9/12/2017)...  Consumer reviews on the independent review site Consumer Affairs ... company for hearing aids, ranking it higher than Miracle Ear ... ... For Hearing Aids ... online store that provides high performance, state-of-the-art, German-engineered hearing aids directly ...
Breaking Medicine Technology: