Navigation Links
Alzheimer's imaging study identifies changes in brain's white matter
Date:6/28/2010

LEXINGTON, Ky. (June 28, 2010) − Scientists at the University of Kentucky's College of Medicine have identified changes in the brains of normal individuals at high risk for Alzheimer's disease that could prove important for early detection of the disease.

The research, led by Brian Gold, associate professor of anatomy and neurobiology, focused on the brain's white matter, which forms the majority of deep parts of the brain and consists primarily of myelinated nerve cell processes, or axons. These myelinated axons serve to connect the brain's gray matter regions, which contain nerve cell bodies.

"The brain's white matter can be thought of as a set of telephone wires which enable communication between gray matter 'thinking regions'," Gold said.

Previous studies have demonstrated decline in both gray and white matter tissue types in individuals with Alzheimer's. In the present study, the authors sought to determine which of these changes are present in normal seniors at high risk for Alzheimer's disease, a likely target group for emerging interventions.

The high-risk group consisted of individuals whom have both genetic and family risk factors for Alzheimer's disease but do not yet show cognitive changes. The low-risk control group consisted of individuals who had neither risk factor but were similar to the high-risk group in terms of age, education level and cognitive functioning.

The study used several magnetic resonance imaging (MRI) techniques to assess the integrity of gray matter and white matter brain tissue in the high and low risk groups. In particular, a recently developed form of MRI called diffusion tensor imaging (DTI) was used to assess the integrity of the brain's white matter. This technique allows for assessment of the microstructural integrity of axons and their surrounding myelin.

Results indicated that the two groups did not differ in the tissue volumes of several gray matter regions know to contribute to memory function. However, the high-risk group showed decreased integrity in white matter tracts that inter-connect gray matter regions involved in memory function. Both the axonal and myelin integrity of these white matter tracts were reduced.

These data suggest that changes in white matter connections may be among the earliest brain changes in Alzheimer's disease, which may prove important for early detection by non-invasive imaging. In addition, the findings may have implications for the development of new preventative treatment interventions in Alzheimer's disease, which could attempt to protect axon and myelin integrity in seniors at risk for this neurological disorder.


'/>"/>

Contact: Keith Hautala
keith.hautala@uky.edu
859-257-1754
University of Kentucky
Source:Eurekalert

Related medicine news :

1. Volumetrics Medical Imaging, LLC and Medison Co., Ltd. Announce Technology License and Settlement of Patent Litigation
2. Leading Radiologist and Imaging Specialist Joins Children's National Medical Center
3. SNMs 2010 Annual Meeting reveals latest developments in molecular imaging and nuclear medicine
4. SNM 2010 image of the year: Molecular imaging shows parathyroid disease in greater detail
5. UltraLinq Healthcare Solutions and Advanced Imaging Consultants Partner to Provide an Anytime, Anywhere Image Management Solution to the Mobile Market
6. Molecular imaging detects recurrent prostate cancer
7. Accelarad Partners with Visage Imaging, Inc. To Enhance Its Next Generation Medical Image Exchange Solution
8. Molecular imaging and CT colonography team up to bring comfort to patients
9. Simple change results in fewer unnecessary imaging exams for patients
10. Salt Lake City proclaims Molecular Imaging Days during SNMs Annual Meeting in June
11. A useful tool to detect in vivo angiogenesis in IBD patients: Narrow-band imaging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional ... action towards gender equality at their inaugural Summit in New York City in June. ... a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the Mission ... lost souls in the Philippines. “The Journey: From the Mountains to the Mission Field” ... the Bible. She has taught all ages and currently teaches a class of ladies ...
(Date:10/12/2017)... WAUSAU, Wis. (PRWEB) , ... October 12, 2017 ... ... formulated standard products to meet the demand of today’s consumer and regulatory authorities ... team of probiotic experts and tested to meet the highest standard. , ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, ... a medical article to the newly revamped Cosmetic Town journal section, ... hair transplant procedure known as Follicular Unit Extraction (FUE). , Dr. ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... the nation's first interactive health literacy software tool, and the Cancer Patient Education ... of cancer patient education, today announce a new strategic alliance. , As ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2, 2017 The Rebound mobile app is poised ... reverse the tide of prescription drug addiction. The app empowers ... intake and stepping down their dosage in a safe, controlled ... December 2017; the first 100,000 people to sign up will ... http://www.rebound-solution.com/ ...
(Date:9/27/2017)... 27, 2017  Commended for their devotion to personalized service, ... as number one in the South Florida Business Journal,s 50 ... 5000 yearly list, the national specialty pharmacy has found its ... will soon be honored by SFBJ as the 2017 ... Set to receive his award in October, Bardisa said ...
(Date:9/25/2017)...  EpiVax, Inc., a leader in the fields ... announced the launch of EpiVax Oncology Inc., a ... cancer vaccines. EpiVax has provided $500,000 in seed ... technologies to the new precision immunotherapy venture. Gad ... as Chief Executive Officer. Gad brings over 25 ...
Breaking Medicine Technology: