Navigation Links
Alzheimer's disease protein controls movement in mice
Date:6/21/2013

HEIDELBERG, 21 June 2013 Researchers in Berlin and Munich, Germany and Oxford, United Kingdom, have revealed that a protein well known for its role in Alzheimer's disease controls spindle development in muscle and leads to impaired movement in mice when the protein is absent or treated with inhibitors. The results, which are published in The EMBO Journal, suggest that drugs under development to target the beta-secretase-1 protein, which may be potential treatments for Alzheimer's disease, might produce unwanted side effects related to defective movement.

Alzheimer's disease is the most common form of dementia found in older adults. The World Health Organization estimates that approximately 18 million people worldwide have Alzheimer's disease. The number of people affected by the disease may increase to 34 million by 2025. Scientists know that the protein beta-secretase-1 or Bace1, a protease enzyme that breaks down proteins into smaller molecules, is involved in Alzheimer's disease. Bace1 cleaves the amyloid precursor protein and generates the damaging Abeta peptides that accumulate as plaques in the brain leading to disease. Now scientists have revealed in more detail how Bace1 works.

"Our results show that mice that lack Bace1 proteins or are treated with inhibitors of the enzyme have difficulties in coordination and walking and also show reduced muscle strength," remarked Carmen Birchmeier, one of the authors of the paper, Professor at the Max-Delbrck-Center for Molecular Medicine in Berlin, Germany, and an EMBO Member. "In addition, we were able to show that the combined activities of Bace1 and another protein, neuregulin-1 or Nrg1, are needed to sustain the muscle spindles in mice and to maintain motor coordination."

Muscle spindles are sensory organs that are found throughout the muscles of vertebrates. They are able to detect how muscles stretch and convey the perception of body position to the brain. The researchers used genetic analyses, biochemical studies and interference with pharmacological inhibitors to investigate how Bace1 works in mice. "If the signal strength of a specific form of neuregulin-1 known as IgNrg1 is gradually reduced, increasingly severe defects in the formation and maturation of muscle spindles are observed in mice. Furthermore, it appears that Bace1 is required for full IgNrg1 activity. The graded loss of IgNrg1 activity results in the animals having increasing difficulties with movement and coordination," says Cyril Cheret, the first author of the work.

Drug developers are interested in stopping the Bace1 protein in its tracks because it represents a promising route to treat Alzheimer's disease. If the protein were inhibited, it would interfere with the generation of the smaller damaging proteins that accumulate in the brain as amyloid plaques and would therefore provide some level of protection from the effects of the disease. "Our data indicate that one unwanted side effect of the long-term inhibition of Bace1 might be the disruption of muscle spindle formation and impairment of movement. This finding is relevant to scientists looking for ways to develop drugs that target the Bace1 protein and should be considered," says Birchmeier. Several Bace1 inhibitors are currently being tested in phase II and phase III clinical trials for the treatment of Alzheimer's disease.


'/>"/>

Contact: Barry Whyte
barry.whyte@embo.org
European Molecular Biology Organization
Source:Eurekalert

Related medicine news :

1. Immunoglobulins Market to 2019 - Demand in Primary Immunodeficiency And CIDP Potentially Supplemented by Approval for Alzheimers Disease Available at ResearchMoz.us
2. AMA’s Classification of Obesity as a Disease Will Enhance Patient Care, Treatment and Prevention
3. Arizona Blogger With Celiac Disease Determined to Write About Her Gluten-Free Journey
4. Millions Are Risking Gum Disease, Warn Eludril And Elgydium
5. Diabetes Patients That Bring Glucose Meters to Doctor Visits Have Better Control Over Their Disease
6. Staging system in ALS shows potential tracks of disease progression, Penn study finds
7. Antioxidant shows promise in Parkinsons disease
8. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces Improved hCG Diet Plans, Fast Weight Loss Now Thought to Decrease Risk of Heart Disease
9. Rare genomic mutations found in 10 families with early-onset, familial Alzheimers disease
10. Certain types of graft-versus-host disease may increase risk of death, Moffitt researcher says
11. CNIC researchers find a possible treatment for one of the main symptoms of premature aging disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... As reported by MassGeneral.org, on May 8 ... in the United States . The 64-year-old patient who received the transplant had undergone ... restore not only a natural appearance, but also urinary and sexual function for the ...
(Date:5/24/2016)... ... May 24, 2016 , ... Local chiropractor ... on September 21, 2016. Dr. Gerard, who holds a Doctorate of Chiropractic and ... organization promoting health and wellness in Third World countries where resources are limited. ...
(Date:5/24/2016)... ... ... "ProText Layouts Vol. 3 is a plugin that will keep your audience ... ProText Layouts Vol. 3 is a set of 30 self-animating kinetic text layouts created ... editors can create an lively typography video with incredible ease. Utilize intuitive controls to ...
(Date:5/24/2016)... ... May 24, 2016 , ... Since 1946, the doctors and ... From the moment a patient arrives at the office, the staff will make ... each and every patient to create a complete dental treatment plan that is unique ...
(Date:5/24/2016)... Phoenix, AZ (PRWEB) , ... May 24, 2016 , ... ... Surprise, Arizona next month. The new facility is licensed under Dignity Health Arizona ... President and CEO of Dignity Health in Arizona, said that the new facility will ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... Dutch surgeons have launched a ground-breaking medical app to help ... on a global scale. Medical professionals from Europe ... and the US have already signed up for the app, which ... secure environment. Education  "Imagine a doctor for ... surgeon at Harvard to treat a bomb victim via live streaming ...
(Date:5/23/2016)... , May 23, 2016 Diplomat Pharmacy, Inc. ... annual Fellowship and Internship programs. The hands-on learning experience ... The full-time, paid Fellowship and ... Michigan . Fellows and interns are provided optional ... Flint at the Riverfront Residence Hall ...
(Date:5/23/2016)... WASHINGTON , May 23, 2016 The World ... PrePex device to include adolescents aged 13 years, ... MedTech, can be offered for adult and adolescent males in ... Africa . PrePex was the first male circumcision device ... Circ MedTech,s CEO, Eddy Horowitz said: " The ...
Breaking Medicine Technology: