Navigation Links
Alzheimer's brains found to have lower levels of key protein
Date:9/1/2011

GALVESTON Researchers have found that a protein variation linked by some genetic studies to Alzheimer's disease is consistently present in the brains of people with Alzheimer's. In further biochemical and cell culture investigations, they have shown that this protein, known as ubiquilin-1, performs a critical Alzheimer's-related function: it "chaperones" the formation of amyloid precursor protein, a molecule whose malformation has been directly tied to Alzheimer's pathology.

"What we saw here is that in all 20 of the Alzheimer's brains we examined the ubiquilin-1 protein level was lower, and that's completely new," said University of Texas Medical Branch at Galveston assistant professor Jos Barral, co-author of a paper on the study now online in the Journal of Biological Chemistry. "Our experiments looked at the consequences of decreased ubiquilin-1, and showed that it's necessary for the proper handling of amyloid precursor protein."

APP has been a major focus of Alzheimer's investigators for almost two decades, ever since scientists identified it as the source of so-called "protein plaques," abnormal aggregations of proteins nearly always found in the brains of Alzheimer's victims. Ubiquilin-1's significance was revealed after the UTMB researchers established ubiquilin-1's status as a chaperone protein for APP.

In the origami-like folding process by which proteins arrive at their proper shape, chaperone proteins act as, well, chaperones: they bind to their client proteins and make sure they don't misbehave.

The kind of APP misbehavior Alzheimer's researchers are most concerned about is the formation of toxic aggregations of the protein or its breakdown products, both inside and outside brain cells. Through a series of biochemical and cell-culture experiments, the UTMB team was able to show that ubiquilin-1 decreased this aggregation.

"Ubiquilin-1 prevents the APP molecule from falling into a conformation it's not supposed to be in," said UTMB associate professor Darren Boehning, co-author of the Journal of Biological Chemistry paper. "This fits with a theme we're seeing across the neurodegenerative disorders and the disorders of aging - the idea that many of these disorders are associated with decreased quality control by chaperones."


'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Related medicine news :

1. Learning information the hard way may be best boot camp for older brains
2. Profound reorganization in brains of adults who stutter
3. Like Those in Humans, Baby Chimps Forebrains Immature
4. Concussion Project Finds Disease in Two Autopsied Brains
5. Human Brains Wired to Empathize, Study Finds
6. Picower: 1 skull + 2 brains = 4 objects in mind
7. Some Brains Easily Distracted by Rewarding Stimuli
8. Scientists Find Molecular Similarities in Brains of Those With Autism
9. Mammals Brains Grew Larger to Enhance Sense of Smell: Study
10. Brains of Autistic Kids Still Larger at Age 4, 5
11. Researchers observe disruptions of daily rhythms in Alzheimers patients brains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2017)... ... , ... Japanese Zen artist couple, Fumie and Kentaro Mune, have announced to ... at Miranda Kuo Gallery on Lower East Side, NYC. This exhibition will feature some ... Wanderlust , one of the largest US yoga online media outlets in the world, ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... serving communities in northern Alabama and Georgia, is embarking on an extended charity ... utilizing modern early detection methods. , US Breast Cancer statistics show that ...
(Date:9/20/2017)... ... 2017 , ... Collins Concrete Coatings announced that they offer ... safety and cleanliness. This unique flooring system uses silver ion technology to resist ... for its antimicrobial properties. Unlike antibiotics, which kill specific microorganisms, silver ions attack ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... company specializing in medical device compliance and commercialization, has just released a ... activities. , FDA is more adamant than ever about medical device, pharmaceutical, ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... innovation, the company recently unveiled a redesigned website. The new site – still ... of building owners, architects, contractors and other industry users that Garland serves. , ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... , Sept. 6, 2017 NeuroRx, a clinical stage ... Ideation and Behavior (ASIB), has been granted Fast Track status ... therapy of NRX-100 (ketamine HCl) followed by NRX-101 (D-cycloserine + ... pivotal trial of this sequential therapy targeting patients who are ... ...
(Date:9/5/2017)... , Sept. 5, 2017  Getinge, a ... created a vibrant charitable donation program -- "Color ... support congenital heart defect research by The Children,s ... and the general public are encouraged to download ... submit the completed artwork to the gallery on ...
(Date:9/1/2017)... , Sept. 1, 2017  Explorers Like Us ( ... America,s greatest aural experiences — and deliver these experiences as ... to help people feel and heal better. ... While nothing beats a walk, ... refresh your mind, Life Environments™ is the next best thing ...
Breaking Medicine Technology: