Navigation Links
Alzheimer's Signs Found in Brains of Young Adults With Gene Mutation
Date:11/6/2012

TUESDAY, Nov. 6 (HealthDay News) -- Scientists have discovered the earliest known evidence of Alzheimer's disease in people with a gene mutation that causes a rare form of the disease that begins at a young age.

The findings from the two studies could improve understanding of how and why Alzheimer's progresses and possibly lead to earlier detection of the disease and improved treatments, according to the researchers.

In one study, researchers conducted brain scans and other tests on 44 young adults, aged 18 to 26, in Colombia. Twenty of them had a mutation of a gene called presenilin 1 (PSEN1) that causes Alzheimer's to develop at an unusually early age, and 24 did not have the mutation. None of the participants showed any signs of mental decline at the time of the study.

There were notable differences in brain structure and function between the young adults with the PSEN1 mutation and those without it. The participants with the PSEN1 mutation had greater activity in regions of the brain called the hippocampus and the parahippocampus, and less gray matter in certain brain areas.

In addition, the cerebrospinal fluid of the young adults with the PSEN1 mutation had higher levels of amyloid beta protein, which is a component of the amyloid plaques in the brain that are associated with Alzheimer's disease.

On average, people with the PSEN1 mutation start to show signs of mental decline at age 45. This study shows that biomarkers in these people are evident at least 20 years before symptoms begin to appear. That's earlier than any previous study has found.

The study was published Nov. 5 in The Lancet Neurology.

"These findings suggest that brain changes begin many years before the clinical onset of Alzheimer's disease, and even before the onset of amyloid plaque deposition. They raise new questions about the earliest brain changes involved in the predisposition to Alzheimer's and the extent to
'/>"/>

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Simple ovarian cancer symptom survey that checks for 6 warning signs may improve early detection
2. Signs of ADHD Evident by Preschool, Expert Says
3. Bone marrow transplant eliminates signs of HIV infection
4. EP Global Communications, Inc. Achieves Shareholder Approval for Restructuring and Signs Definitive Restructuring Agreement
5. Boys Town Releases 5 Signs of Heat Stroke in Kids
6. Symtrex Inc. Signs Up with ImmuneSecurity to Launch LogInspect to the North American Market
7. TeetheMe.com Partners with SwaddleDesigns
8. Obese Teens Can Have Heart Damage Without Showing Signs
9. A place to play: Researcher designs schoolyard for children with autism
10. Even Young Teens Show Signs of Sun Damage
11. Bacteria Found in Other Products From Firm Tied to Meningitis Outbreak: FDA
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Alzheimer's Signs Found in Brains of  Young Adults With Gene Mutation
(Date:4/24/2014)... influenza pH1N1 virus caused the first flu pandemic in ... 2009 and killed more than 50 people in the ... during flu epidemics (winter/spring seasons). , Infections with ... illnesses. World Health Organization has recommended Tamiflu for treatment ... of this drug is that it targets viral proteins ...
(Date:4/23/2014)... from healthy, unrelated donors was safe and effective ... by Clostridium difficile , according to a ... Diseases and available online. Known as fecal ... given via a colonoscope or a nasogastric tube. ... promising treatment more readily available to patients. , ...
(Date:4/23/2014)... Washington State University Spokane have developed a new ... nod off behind the wheel. , Their recently ... are more variable in drowsy driversand offers an ... video-based driver drowsiness detection systems. , Van Dongen"Video-based ... car is drifting out of its lane are ...
(Date:4/23/2014)... April 23, 2014 The American Society for Radiation ... Role of Postoperative Radiation Therapy for Endometrial Cancer: ... of adjuvant radiation therapy in the treatment of ... in the May-June 2014 issue of Practical ... journal of ASTRO. The full-length guideline is available ...
(Date:4/23/2014)... pathway that helps prevent new cells from receiving too ... been directly linked to cancer and other diseases. , ... the end of cell division, the enzyme Cdc14 activates ... are fully repaired before the parent cell distributes copies ... safeguard against some of the most devastating genome errors, ...
Breaking Medicine News(10 mins):Health News:Pilot study suggests ways to widen access to fecal transplants for C. diff infections 2Health News:WSU innovation improves drowsy driver detection 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 3Health News:Study identifies enzymes that help fix cancer-causing DNA defects 2
... Endocrine Society,s Journal of Clinical Endocrinology & Metabolism ... corn syrup for two weeks as 25 percent of their ... triglycerides, which have been shown to be indicators of increased ... that people consume only five percent of calories as added ...
... interpret mammograms does not improve accuracy, according to a study ... National Cancer Institute. CAD software, used currently ... States, identifies patterns associated with breast cancers and marks potential ... recommendation. To learn whether CAD leads to ...
... , WEDNESDAY, July 27 (HealthDay News) -- Scientists who sequenced the ... the deadly food poisoning outbreak in Germany that began in May ... paper was published online July 27 in the New England ... the reasons why this particular strain of E. coli ...
... , WEDNESDAY, July 27 (HealthDay News) -- Many ... behavioral issues often face tough social and academic troubles ... the progress of more than 1,450 students in fourth ... found that one-third coped with special health care needs ...
... Using human breast cancer cells and the protein that causes fireflies ... some breast cancer cells become resistant to the anticancer effects of ... "dimmer switches" that apparently control how a breast cancer gene responds ... July 7 by Human Molecular Genetics , the scientists show ...
... food restaurants and other outlets that sell junk food in your ... burgers and fries and wash them down with a soda. ... from the UCLA Center for Health Policy Research that examined the ... junk food consumption. The upshot? Nearly three-quarters of ...
Cached Medicine News:Health News:Fructose consumption increases risk factors for heart disease 2Health News:Computer-aided detection does not improve mammogram accuracy 2Health News:Gene Study Sheds Light on Deadly German E. Coli Strain 2Health News: Special Needs Kids Bullied More, Fare Poorly at School 2Health News: Special Needs Kids Bullied More, Fare Poorly at School 3Health News:Johns Hopkins researchers discover how some breast cancers alter their sensitivity to estrogen 2Health News:As unhealthy food outlets multiply, teens eat more junk 2
(Date:1/14/2014)... Mass. , Jan. 14, 2014 HeartWare ... leading innovator of less invasive, miniaturized circulatory support technologies ... today announced that it expects revenues for the fourth ... expected full-year 2013 revenues to approximately $208 million. ...
(Date:1/14/2014)... Jan. 14, 2014 Dynamic Healthcare Services, Inc. ("DHS"), a ... it acquired Progressive Home Medical Equipment, Inc. ("Progressive") of ... terms of the acquisition were not disclosed. ... providing a wide range of sleep, mobility, and respiratory products ...
(Date:1/14/2014)... CLEVELAND , Jan. 14, 2014 NineSigma ... will hold its Innovation Leadership Summit , May ... in Cleveland Ohio . ... innovators and organizations committed to breakthrough achievements through open ...
Breaking Medicine Technology:HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... in Canons DR innovations, the CXDI-31 is ... a compact and lightweight design, the Canon ... conventional screen-film cassettes. It is designed to ... to get with fixed devices and supports ...
... a cost-effective synthetic bone filler tailored ... Phosphate (TCP) and Hydroxyapatite (HAP), its ... BAB formulates the chemistry and microstructure ... This formulation provides optimal osteo-conduction. The ...
The Oscor PACE 101 H is an external single chamber cardiac demand pacemaker. The PACE 101 H feature an option for a atrial overdrive stimulation....
... TAU Lead is a ... stimulation lead for temporary ... The unique shaft design ... straight or preformed stylets ...
Medicine Products: