Navigation Links
Alzheimer's Risk Looks Higher if Mom Had the Disease
Date:2/28/2011

By Jenifer Goodwin
HealthDay Reporter

MONDAY, Feb. 28 (HealthDay News) -- A new study adds more weight to research showing the risk of developing Alzheimer's disease is greater if your mother, rather than your father, had the disorder.

Brain scans of adult children of people with Alzheimer's found more shrinkage in key brain regions of those whose mothers had the disease than in those whose fathers had it, the researchers report. Brain shrinkage is a characteristic of the age-related disorder.

"It's consistent with other studies that suggest there is something inherited from mothers that influences risk more so than what is passed down through fathers," said senior study author Dr. Jeffrey Burns, an associate professor of neurology at University of Kansas Medical Center.

Alzheimer's disease has a strong inherited component, according to background information in the study. Those whose parents had the disease are four to 10 times more likely to get the disease themselves.

In the study, researchers created three-dimensional maps, using a technology called voxel-based morphometry, of the brains of 53 people aged 60 and older. Eleven had a mother with Alzheimer's, 10 had a father with Alzheimer's and the rest had no family history of the disease.

None of the participants had dementia when they were recruited, nor did they show the signs of mental decline that can be an early indicator of the disease, researchers said.

After two years, people whose mothers had Alzheimer's had twice the amount of gray matter atrophy, or shrinkage, in brain regions known to be affected by Alzheimer's compared to those with a paternal history or no family history of the disease. The regions included the parahippocampal gyrus and the precuneus.

Those with a maternal history of Alzheimer's also had one and a half times more loss in whole brain volume each year compared to those with a paternal history or no family history of the disease.

The study is published in the March 1 issue of Neurology.

A small amount of brain shrinkage with each passing year is common among older adults and not necessarily a sign of Alzheimer's, Burns noted.

However, with Alzheimer's, the atrophy occurs much faster.

Researchers don't know what the Alzheimer's-related inheritance from mothers is, but they theorize that it may have something to do with mitochondrial dysfunction. Mitochondria, which generate the energy that cells use to function, are inherited only from mothers.

Prior research has linked mitochondrial problems and Alzheimer's disease, Burns said.

"This suggests that the mitochondrial dysfunction may have more to do with Alzheimer's than we previously have considered," he said.

Dr. Steven DeKosky, a professor of neurology at University of Virginia School of Medicine, said too few participants were involved in the study to draw a conclusion. Larger studies are needed to confirm the findings, he said. In addition, researchers did not test for specific proteins associated with Alzheimer's, such as those found in cerebrospinal fluid.

Testing for those protein markers could confirm if the atrophy was indeed due to Alzheimer's, DeKosky said.

"I would be very cautious about reaching any firm conclusions about genetics from this study," DeKosky said.

"They probably have identified AD [Alzheimer's disease] cases which are presymptomatic, but whether the male-female difference will be maintained would await larger numbers of cases, perhaps more thoroughly characterized," he added.

With Americans living longer, cases of Alzheimer's disease are soaring in the United States. By 2030, about 20 percent of the total U.S. population will likely have the disorder, the Alzheimer's Association estimates.

More information

The U.S. National Institute on Aging has more on Alzheimer's.

SOURCES: Jeffrey Burns, M.D., associate professor, neurology, University of Kansas Medical Center, Kansas City; Steven DeKosky, M.D., professor, neurology, University of Virginia School of Medicine, Charlottesville; March 1, 2011, Neurology


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Scanning for skin cancer: Infrared system looks for deadly melanoma
2. Lighthouse International Introduces a New, Customizable, Low-Vision Simulator That Shows How the World Looks to People Who Are Visually Impaired
3. Vaccine for Asbestos-Related Cancer Looks Safe
4. Heart Aflutter? Remarkable New Images Show What it Looks Like in 4-D
5. Study Looks At Cost-Effectiveness of ECG in Hyperactive Kids
6. An Earth Day View of Green Building: Earth Advantage Institute Looks 10 Years Forward
7. Cruise Plastic Surgery Looks at Mommy Makeovers from the Husband's Perspective and Offers Tips
8. National Insurance Company Looks to Indianapolis-based TriDigital Solutions for Affordable CD Replication and Mailing Project
9. If the water looks and smells bad, it may be toxic
10. New Procedure for Aortic Valve Replacement Looks Promising
11. Research looks at stuttering differences in boys, girls
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Alzheimer's Risk Looks Higher if Mom Had the Disease
(Date:1/18/2017)... , ... January 18, 2017 , ... ... asset protection and financial planning services to families and business owners in the ... aimed at supporting children with developmental disabilities. , The Lakemary Center is a ...
(Date:1/18/2017)... ... January 18, 2017 , ... Catalent ... for drugs, biologics and consumer health products, today announced that Mr. Michael Merges, ... upcoming WCBP Conference, to be held at the Mayflower Hotel, Washington DC, on ...
(Date:1/18/2017)... , ... January 18, 2017 , ... ... the revolutionary Active Brake Technology (ABT), an innovative braking system that allows skaters ... Brake Technology addresses one of the biggest concerns of beginner and intermediate skaters ...
(Date:1/17/2017)... Michigan (PRWEB) , ... January 17, 2017 , ... January is National Stalking Awareness ... who choose to lurk in the corners and commit the crime of stalking, a very ... use and addiction, an often overlooked factor in stalking and other crimes. , “Stalking: know ...
(Date:1/17/2017)... , ... January 17, 2017 , ... ... point of difference. Eden Activewear is a stand-out company for several differences from ... online and only manufacture on demand, this is called 'Agile' manufacturing - ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... , Jan. 18, 2017  Dermata Therapeutics, LLC, ... to treat a variety of dermatological diseases, announces ... DMT210, in a Phase 2 acne rosacea study. ... downregulate the proinflammatory cytokines in the skin responsible ... rosacea. This clinical trial, DMT210-003, ...
(Date:1/18/2017)... Safe Rx LLC and Good Day Pharmacy, ... Loveland, Colorado , today announced the availability ... Day locations.     "Patients with prescriptions prone ... storage," said Milton Cohen , President & CEO ... a cup of coffee, you can protect your children ...
(Date:1/18/2017)... In China , we say Health is ... China,s Healthy Strategy originates. 2016 is ... and Social Development of the People,s Republic of ... council of the People,s Republic of China ... plan, identifying medical devices as one of the main breakthrough ...
Breaking Medicine Technology: