Navigation Links
Alzheimers Research Target May Be a Dead End
Date:1/27/2008

as potential Alzheimer's therapies: "They should stop."

Another expert agreed.

David Lynn is a Howard Hughes Institute investigator and professor of biological chemistry at Emory University in Atlanta. "I think that Brian's paper argues that [scientists] have been missing the boat here," he said. "It's not clear that you are ever going to get the concentrations that you need of these agents at the right site to be able to have any therapeutic intervention."

On the level of basic chemistry, attacking Alzheimer's and other protein-clumping diseases by preventing amyloid from concentrating has "always been a long shot," Lynn said. That's because amyloid proteins are incredibly "sticky," chemically speaking.

"To find things that will competitively stick and stop them from assembling is theoretically hard to imagine," Lynn said. It was thought that individual molecules of amyloid inhibitors might do so, but the new finding -- that the molecules inevitably bind together in a more impractical mass -- renders them therapeutically useless.

But other avenues of Alzheimer's research remain promising, Lynn said.

"There are certainly other strategies that have potential," he noted, including antibody-focused strategies aimed at eliminating plaques, or treatments focused on easing the downstream effects of amyloid buildup.

Both scientists stressed that it's still not certain whether protein plaques even cause Alzheimer's and other brain diseases, or whether they are merely byproducts of the disease process. "That's really another open area of research," Shoichet said.

"The problem with these diseases is that it is such a moving target," Lynn said. "And so, different people are looking at different things."

More information

There's much more on Alzheimer's disease at the Alzheimer's Association.




'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. ITRAC on track and bridging gap between academic research and applied discovery
2. Significant funding for type 1 diabetes research
3. Popular arthritis drug may disrupt heart rhythm, UB research finds
4. From Research to Practice: Healthfitness, Eastman Chemical Company Case Study Demonstrates Real-World Health Gains and Productivity Savings
5. Pain medicine meeting unites top researchers and clinicians
6. Boston Research Summit gathers 100 health care leaders on decision making
7. First Time Federal Funding for Mesothelioma Research
8. Kroger Pink Tag Campaign Raises $137,500 for Breast Cancer Research and Awareness at Karmanos Cancer Institute
9. Researchers identify brains eureka circuitry
10. Iowa State University researchers work on gender, temperature link in reptiles published in Nature
11. 2008 ASM Biodefense and Emerging Disease Research Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Alzheimers Research Target May Be a Dead End
(Date:7/31/2014)... July 31, 2014 In today’s world, a ... to get. Snoring and sleep apnea (a medical problem where ... and their bed partners of the rest they need to ... the population snores and 20 million people in the United ... been diagnosed and treated; and of those treated, many cannot ...
(Date:7/31/2014)... 31, 2014 Adventist Health System, ... U.S. including Florida Hospital Tampa, Florida Hospital Carrollwood, ... Hospital North Pinellas, Florida Hospital Wesley Chapel, Florida ... Florida Hospital Heartland Medical Center Lake Placid and ... list of Most Wired Hospitals and Health Systems, ...
(Date:7/31/2014)... Peninsula, MI (PRWEB) July 31, 2014 The ... preparation of the upcoming harvest. And, to celebrate, folks are ... Saturday and Sunday, September 6 and 7, 2014 along the ... festivities is an optional walk or run through the vineyards ... Winery in Suttons Bay. A unique course between rows of ...
(Date:7/31/2014)... July 31, 2014 Weblify has finally been ... years of development and testing. The result is a ... in as little as 5 minutes without knowing any HTML ... review , Shane Michaels, an SEO expert, agrees that this ... “I’ve seen a lot of web site builders out there, ...
(Date:7/31/2014)... Ohio (PRWEB) July 31, 2014 United ... of its faculty, Anthony Le Donne and Peter J. ... Also new to United is a Director of ... August 1. , Anthony Le Donne, Assistant Professor ... United Kingdom. He teaches New Testament, Second Temple Judaism, ...
Breaking Medicine News(10 mins):Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Florida Hospital West Florida Region is Among the Most Wired Hospitals and Health Systems in the United States 2Health News:Leelanau Peninsula’s Annual Harvest Stompede Offers a Unique Vineyard Course for Walkers, Runners and Wine Tasters 2Health News:Weblify Review Exposes Ricky Mataka And His New Site Building Platform 2Health News:Weblify Review Exposes Ricky Mataka And His New Site Building Platform 3Health News:Growing Seminary Welcomes New Faculty 2
... alternative remedies more likely to misuse prescribed drugs, suffer ... Many asthma patients who use herbal remedies experience increased ... shows. , Researchers followed 326 asthma patients for 33 ... herbal remedies and used prescribed inhaled corticosteroids (ICS) less ...
... Insurance Companies Amend Policy on Radioembolization Coverage , OTTAWA, ... global leader in providing products and services for medical ... largest health insurers in the United States ... liver cancer, which includes the use of MDS Nordion,s ...
... , ... costs, boost efficiency , SILVER SPRING, Md. , ... Administration today issued guidance on Bayesian statistical methods in the ... result in less costly and more efficient patient studies. , ...
... recognized as a complication of erosive esophagitis and is ... A research team from Yokohama City University School of ... might be useful for identifying a subgroup with a ... study will be published on January 28, 2010 in ...
... Whitewater Courses and ... challenge participants with hard-to-hear truths about the responsibilities of developers who promote atop the ... designers, engineers and river scientist will take place May 24-27, 2010 in Salida, CO. ... (PRWEB) March 3, 2010 -- ...
... sugar of children, teens stable longer , THURSDAY, Feb. 4 ... teenagers with type 1 diabetes could benefit by using an ... blood sugar levels during sleep and help them control their ... issue of The Lancet , examined use of an ...
Cached Medicine News:Health News:Herbals Not the Answer for Asthma, Study Shows 2Health News:MDS Nordion's TheraSphere(R) for Unresectable Liver Cancer (HCC) Now Covered by Two Large U.S. Insurers 2Health News:MDS Nordion's TheraSphere(R) for Unresectable Liver Cancer (HCC) Now Covered by Two Large U.S. Insurers 3Health News:MDS Nordion's TheraSphere(R) for Unresectable Liver Cancer (HCC) Now Covered by Two Large U.S. Insurers 4Health News:FDA Issues Guidance to Help Streamline Medical Device Clinical Trials 2Health News:FDA Issues Guidance to Help Streamline Medical Device Clinical Trials 3Health News:Hard Green Truths - Keynotes Suggest New Value Propositions for River Park Leaders 2Health News:Artificial Pancreas Helps Type 1 Diabetics During Sleep 2
(Date:7/31/2014)... , July 31, 2014 AFFiRiS AG ... York results of AFF008, a Phase I clinical ... the first therapy against the protein alpha-synuclein, a promising Parkinson,s ... J. Fox Foundation for Parkinson,s Research (MJFF) supported the study ... press conference on the impact a disease-modifying therapy would have ...
(Date:7/31/2014)... , July 31, 2014 genae, a ... industries, announced today the incorporation of genae UK in ... has one of the largest medical device markets in the ... it is projected to increase by a CAGR of 6.0% until ... equal to 9.5% of GDP. Despite recessionary pressures, market growth rates ...
(Date:7/31/2014)... AUSTIN, Texas , July 31, 2014 Vermillion, ... cancers and women,s health, will hold a conference call on ... discuss results for the second quarter ended June 30, 2014. ... to the call. Vermillion,s Chairman, President and CEO ... a question and answer period. Date: Thursday, August ...
Breaking Medicine Technology:First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 2First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 3First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 4genae Opens Offices in London 2Vermillion Sets Second Quarter 2014 Conference Call for Thursday, August 14, 2014 2
... has collaborated with the National Comprehensive Cancer Network® (NCCN®) ... ( NCCN Guidelines ™) into Elekta,s MOSAIQ® Oncology Information ... NCCN,s evidence-based clinical content directly from within the MOSAIQ ... Guidelines are widely recognized as the standard ...
... 8, 2011 BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ... Product Development of BioMarin, will present a company update at ... June 15, 2011 at 10:00 a.m. CT.   ... conference call via the investor section of the BioMarin website, ...
Cached Medicine Technology:National Comprehensive Cancer Network Guidelines Available in Elekta's MOSAIQ EMR 2BioMarin to Present at the William Blair Growth Stock Conference 2
Retractable, straight double Lancet Blade, 15 Degree Angle , available in variations; Titanium handle...
10mm Tip to Bend, 0.3mm Y Tip; In Titanium....
Bend with "H" Shaped Tip, LEFT; in Titanium....
Bend with "H" Shaped Tip, Right; Stainless Steel....
Medicine Products: