Navigation Links
Alzheimers Research Target May Be a Dead End
Date:1/27/2008

Amyloid inhibitors cant prevent brain plaque build-up, study suggests

SUNDAY, Jan. 27 (HealthDay News) -- A once-promising pathway for research into preventing and treating Alzheimer's disease may have been derailed by a surprise chemical finding, researchers report.

Scientists in laboratories around the world have been investigating drug candidates called amyloid inhibitors, which many experts believed could keep proteins such as amyloid-beta from sticking together in brain tissue.

This type of "sticky" protein plaque build-up is a hallmark of Alzheimer's disease. It also characterizes brain illnesses such as Huntington's disease and "mad cow" disease.

But the new study, published Jan. 27 in the journal Nature Chemical Biology, may sound an unexpected death knell for amyloid inhibitor research.

In the study, a team of chemists at the University of California, San Francisco, found that these candidate drugs form large, unwieldy clumps themselves, rendering them useless as targeted therapy against amyloid in the brain.

High-tech research in the lab is revealing that typical amyloid inhibitors "seem to act not in the way people expect them to and want them to," explained study senior author Brian Shoichet, professor of pharmaceutical chemistry at UCSF.

Once these drugs aggregate into clumps, "they no longer have the right pharmacology, they won't cross the [brain's] membrane barriers, and they inhibit everything -- any protein will bind with them," he said.

In other words, the drugs lose their ability to migrate to the brain to fight amyloid plaque. They also give up their targeted specificity against amyloid, Shoichet said. "They end up inhibiting everything -- any protein that sees them will be sequestered by them," he said. This molecular clumping process is largely inevitable, Shoichet added.

His advice to neuroscientists investigating these agents
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. ITRAC on track and bridging gap between academic research and applied discovery
2. Significant funding for type 1 diabetes research
3. Popular arthritis drug may disrupt heart rhythm, UB research finds
4. From Research to Practice: Healthfitness, Eastman Chemical Company Case Study Demonstrates Real-World Health Gains and Productivity Savings
5. Pain medicine meeting unites top researchers and clinicians
6. Boston Research Summit gathers 100 health care leaders on decision making
7. First Time Federal Funding for Mesothelioma Research
8. Kroger Pink Tag Campaign Raises $137,500 for Breast Cancer Research and Awareness at Karmanos Cancer Institute
9. Researchers identify brains eureka circuitry
10. Iowa State University researchers work on gender, temperature link in reptiles published in Nature
11. 2008 ASM Biodefense and Emerging Disease Research Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Alzheimers Research Target May Be a Dead End
(Date:12/24/2014)... Dr. Svetlana Gomer, MGS Tewksbury Dental, MGE ... with US Marines on November 14, 2014 for the ... Toys for Tots Literacy Program. This year’s event ... and audio books for the Toys for Tots Literacy ... It represents another major strike in the battle being ...
(Date:12/24/2014)... FL (PRWEB) December 24, 2014 There’s a ... days. With the Republican Party now in control of the ... again for the Affordable Care Act. A lawsuit has been ... delays of certain provisions in the ACA have resulted in ... Also, a Supreme Court hearing will take place to weigh ...
(Date:12/24/2014)... (PRWEB) December 24, 2014 Dental implants ... for a tooth replacement. They offer the strongest and ... advantages over other forms of tooth replacement. They will ... on the adjacent teeth for support, and they prevent ... have been told that they are not suitable candidates ...
(Date:12/24/2014)... Las Vegas, NV (PRWEB) December 24, 2014 ... Home Services reminds homeowners that before investing time ... start by consulting a licensed professional that specializes in ... who may plan to replace their water heater in ... making a final decision. , Greenstar Home Services ...
(Date:12/24/2014)... December 24, 2014 In June 2014, ... States rode bicycles, hand cycles and recumbent bicycles nearly ... the inaugural CanAm Veterans’ Challenge . “Capital to ... T.E.A.M. Sports about this inspiring ride, is now available ... 50 full color photographs taken during the two-week ride, ...
Breaking Medicine News(10 mins):Health News:Dr. Svetlana Gomer, MGS Tewksbury Dental and Other Dentists Working With the U.S. Marines Strike Again In the Battle Against Illiteracy 2Health News:Dr. Svetlana Gomer, MGS Tewksbury Dental and Other Dentists Working With the U.S. Marines Strike Again In the Battle Against Illiteracy 3Health News:Steven Gerst MD Discusses How, Amid Political Opposition, Court Challenges, and a New Open Enrollment Period, the Affordable Care Act still Relies on Health Informatics 2Health News:Steven Gerst MD Discusses How, Amid Political Opposition, Court Challenges, and a New Open Enrollment Period, the Affordable Care Act still Relies on Health Informatics 3Health News:Innovative Dental Implant Procedure to Gain Momentum in the New Year 2Health News:Greenstar Home Services Offers Tankless Water Heater Advice to Local Homeowners 2Health News:New Commemorative Book Celebrates CanAm Veterans’ Challenge Bike Ride 2Health News:New Commemorative Book Celebrates CanAm Veterans’ Challenge Bike Ride 3
... of combating atherosclerosis is to reduce levels of bad cholesterol ... Institutet have now identified the genes that bring about this ... mice, which is presented in the open-access journal PLoS Genetics, ... plaque that causes myocardial infarction and stroke can be prevented ...
... Gottsch to Visit Washington, D.C., and Meet with Elected ... Boise,Idaho, will travel to Washington, D.C., this April 1 ... restoration of the,Americans with Disabilities Act, support for epilepsy ... epilepsy., Gottsch, 9, is one of 50 young ...
... with Elected,Officials, WASHINGTON, March 14, - Kevin Tsuchida ... 1 to meet with,congressional leaders and gain their support ... epilepsy public health,programs and more research toward a cure ... young people with epilepsy participating in,Kids Speak Up!, a ...
... to Visit Washington, D.C., and Meet with,Elected Officials, ... Fitzhugh of San Antonio will travel to Washington, D.C.,this ... their support for,restoration of the Americans with Disabilities Act, ... a cure for epilepsy., Eubank and Fitzhugh, both ...
... 14 NHS Choices ( http://www.nhs.uk ), ... a new Live Well package on,pregnancy, aimed ... keeping well during,pregnancy., Based on NHS ... provides,users with information about staying healthy and ...
... SEGUNDO, Calif., March 14 Murad, where ... Lori Jacobus as the,company,s new Vice President ... will take a pivotal lead in driving ... initiatives, identifying new market,opportunities, driving product development, ...
Cached Medicine News:Health News:Idaho Youth Named National Epilepsy Spokesperson 2Health News:Washington Youth Named National Epilepsy Spokesperson 2Health News:Texas Youths Named National Epilepsy Spokespersons 2Health News:Murad, Inc., Hires Lori Jacobus as Vice President of Global Marketing 2
(Date:12/22/2014)... , Dec. 22, 2014 Apnea Sciences ... corporate offices in Aliso Viejo , ... due to the tremendous growth and worldwide expansion, a ... of patented SnoreRx, the anti snore cure have exceeded ... said, "We are now in 23 countries and ...
(Date:12/22/2014)... 22, 2014  ConvaTec, a privately-held medical products and ... appointed Interim Chief Executive Officer of the company, effective ... Ken Berger .  "The Board of Directors of ConvaTec ... over the past three years," said Magnus Lundberg ... are confident that the company is well positioned for ...
(Date:12/22/2014)...  Mark Farrah Associates (MFA), www.markfarrah.com , ... the 2015 marketplace exchange projections and insights about ... According to a recent ASPE (Office of the ... Health and Human Services) report, an estimated 6.7 ... through the Marketplace as of October 2014 and ...
Breaking Medicine Technology:ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2Insights into the Marketplace and Individual Market Growth 2
... , SAN DIEGO, Dec. 15 Volcano Corporation ... intravascular therapy guidance tools - including Fractional Flow Reserve ... Coherence Tomography (OCT) - designed to enhance the diagnosis ... today the placement of over 2,500 s5 family consoles ...
... CITY, Dec. 15 Sonic Innovations, Inc. (Sonic), a Utah-based ... to its local Feeding America network member food bank on ... presented the $10,000 check to the local Feeding America member, ... City location. Sonic employees also participated in an office food ...
Cached Medicine Technology:Volcano Announces Installed Base Growth Milestone 2Volcano Announces Installed Base Growth Milestone 3Volcano Announces Installed Base Growth Milestone 4Volcano Announces Installed Base Growth Milestone 5Sonic Innovations, Inc. Donates $10,000 to Feeding America 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: