Navigation Links
Alzheimer's Plaques Can Form in One Day
Date:2/6/2008

Study also notes that related neuronal damage follows soon after

WEDNESDAY, Feb. 6 (HealthDay News) -- An advanced imaging study has captured the fact that amyloid plaques, the harbingers of Alzheimer's disease, can develop in just 24 hours.

"They form more rapidly than expected," said Dr. Bradley Hyman, leader of the group reporting the finding in the Feb. 7 issue of Nature. Once the plaques develop, damage is evident in nearby nerve cells almost immediately, he added.

"The study we've done, using an animal model of Alzheimer's disease, tried to sort out the order in which things occur," said Hyman, director of the Alzheimer's Unit at the Massachusetts General Hospital Institute for Neurodegenerative Disease. "We've had snapshots of individual steps in the past. This microscopic technology gives us the ability to watch the process from beginning to end, to see the variety of things that happen as inflammatory cells get activated."

The microscopic imaging, done first weekly and then daily, found that plaque formation was a relatively rare event. But plaques could be seen in some animals in as little as 24 hours after a plaque-free image was taken.

What happens in the animals, mice bred to develop amyloid plaques, almost certainly happens in the human brain, Hyman said, and the finding could be applied to humans at risk for developing Alzheimer's.

"Knowing that plaque occurs quickly implies that something initiates it," he said. "That is the next question to be answered."

The studies showed that nerve cell changes associated with Alzheimer's disease appear within days. The results confirm suspicions that plaque formation is a primary event in the abnormal cell activity that underlies Alzheimer's disease, Hyman said.

"Watching the pathology unfold in real time dynamically, that is an extremely exciting move forward," said Dr. Sam Gandy, chairman of the Alzheimer's Association medical and scientific advisory council. Gandy recently became associate director of the Alzheimer's Disease Research Center at Mount Sinai Medical Center in New York City.

The finding does have immediate relevance to the effort to develop treatments for Alzheimer's disease, Gandy said. "It reinforces the idea that anti-amyloid medication is a rational strategy," he said. "It reinforces the idea that attacking amyloid plaque helps nerve cells. You can see in nerve cells nearby changes in shape indicating that the cells are reacting to amyloid plaque, that is a link between those features of a pathology."

The study also answers a question about whether amyloid plaque can form only near blood vessels, Gandy said. "There have been reports that every amyloid plaque had a blood vessel somewhere," he explained. "That seems not to be the case."

But formation of amyloid plaque is not the only brain change associated with Alzheimer's disease, Hyman noted. Another notable feature consists of changes in the tau proteins that normally provide a scaffold for orderly function of nerve cells in the brain. Those tau proteins can become disordered, forming tangles that lead to destruction of nerve cells.

Studies of the formation of those tangles, using the same technology that led to the plaque discovery, are about to begin, Hyman said.

More information

Keep up to date on Alzheimer's disease by consulting the Alzheimer's Association.



SOURCES: Bradley Hyman, M.D., Ph.D., director, Alzheimer's Unit, Massachusetts General Hospital, Boston; Sam Gandy, M.D., professor, Alzheimer's Disease Research, and associate director, Alzheimer's Disease Research Center, Mount Sinai Medical Center, New York City; Feb. 7, 2008, Nature


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Alzheimers Research Target May Be a Dead End
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Alzheimer's Plaques Can Form in One Day
(Date:8/22/2017)... ... ... past six years, Lightning Labels has sent out a call for users of its custom ... creativity of their designs. Submissions this year were open from May 18 to July 1 ... winners of the sixth annual Photo Contest, along with the prizes they've received:, ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Wilderness Voices”: a collection ... travel. “Wilderness Voices” is the creation of published author, Martha McKown, an ordained ... was inspired as a very young child when her older sisters studied High School ...
(Date:8/22/2017)... ... , ... TopConsumerReviews.com recently gave a best-in-class 5-star rating to Energy NADH, a ... of modern life continually makes more demands on time and energy, people are finding ... people in vicious high/low cycles and can also cause long term health issues. More ...
(Date:8/21/2017)... ... August 22, 2017 , ... ... I. Stevens as a 2017-2018 inductee into its VIP Woman of the ... NAPW is the nation’s leading networking organization exclusively for professional women, boasting more ...
(Date:8/21/2017)... ... 2017 , ... Marathon running has surged in popularity in ... running increases exposure to ultraviolet radiation, a carcinogen that promotes skin cancer. Studies ... half may be adequately protecting themselves with proper clothing and sunscreen. , ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... , Aug. 2, 2017 ... Who,s Who as a Pinnacle Lifetime Professional in ... Key Account Manager at Turing Pharmaceuticals, AG. Her ... troubleshooting and relationship building.                ... more than 25 years of experience as a ...
(Date:7/31/2017)... Pharmacy, Inc. (NYSE: DPLO), has been named one of the ... Crain,s Detroit Business . The annual Crain,s Fast ... growth. This year,s edition measures growth from 2013 to 2016. ... list, visit crainsdetroit.com/awards/fast_50/2017 .  "Being named ... Phil Hagerman , CEO and chairman of Diplomat. "We,ve made ...
(Date:7/27/2017)... 2017  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH) ... 30, 2017.  The Company reported second quarter net sales ... prior year period, and an increase of 2.1% on ... of contribution from the LDR Holding Corporation acquisition, second ... of 2016, or 0.3% on a constant currency basis. ...
Breaking Medicine Technology: