Navigation Links
Alzheimer's Med Seems Ineffective in Those With Down Syndrome
Date:1/10/2012

TUESDAY, Jan. 10 (HealthDay News) -- A drug commonly used to treat patients with Alzheimer's disease does not appear to be effective for people older than 40 years who have Down syndrome and Alzheimer's, according to a new study.

Although previous animal studies of the Alzheimer's drug, memantine, showed promising results in mice with Down syndrome, this new study of people with Down syndrome aged 40 and older revealed the opposite, the researchers reported in the Jan. 9 online edition of The Lancet.

Memantine was given to 88 people with Down syndrome for one year, while another 85 patients received a placebo (the "control" group). Some of the participants had Alzheimer's and some didn't.

The investigators found that the brain function of the people in both groups declined equally.

Serious adverse effects were experienced by 11 percent of the group that took the medication. Meanwhile, 7 percent of the placebo group had similar adverse events. Five people from the medication group died because of these events, compared to four in the control group.

"Memantine is not an effective treatment in this group of patients. We believe that this robust finding will have implications for clinical practice and research strategy in the future. Specifically, therapies that are beneficial for people with Alzheimer's disease are not necessarily effective for the treatment of cognitive impairment or dementia in the context of Down syndrome," the study's author, Clive Ballard, a professor at the Wolfson Centre for Age-Related Diseases at King's College London, said in a journal news release.

Because nearly 40 percent of people with Down syndrome over 60 years of age are diagnosed with dementia, the study authors pointed out that more research is needed to determine the best way to treat dementia in these individuals.

"Further investment is urgently needed to develop treatments that are effective in this important group of people," the study's co-author, Anne Corbett, research manager at Alzheimer's Society (U.K.), stated in the news release.

More information

The U.S. National Institute of Neurological Disorders and Stroke provides more information on Alzheimer's disease.

-- Mary Elizabeth Dallas

SOURCE: The Lancet, news release, Jan. 9, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Surgery Seems Most Effective for Herniated Discs
2. 1st Artificial Windpipe Made With Stem Cells Seems Successful
3. Newer Drug Seems Better at Controlling Lupus Kidney Complication
4. Regular Exercise Seems to Guard Against Migraine
5. Diabetes Education Seems to Help Improve Blood Sugar Control
6. Heart Defect Seems to Pose Low Risk of Aorta Tear
7. Special Talk Therapy Seems to Help Dying Patients
8. Satisfaction With Life Seems Good for the Heart
9. When It Comes to Memory, Practice Seems to Make Perfect
10. Ovulation Seems to Aid Womens Gaydar
11. Experimental Vaccine Seems to Cure Prostate Cancer in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Alzheimer's Med Seems Ineffective in Those With Down Syndrome
(Date:10/13/2017)... ... October 13, 2017 , ... ... that offers insurance and financial preparation services, is providing an update on a ... organization. , Rock City Rescue is a locally recognized nonprofit that provides shelter ...
(Date:10/13/2017)... ... October 13, 2017 , ... While it’s often important to ... Fortunately, an inventor from Austin, Texas, has identified a solution. , She developed a ... or restricted lighting. As such, it eliminates the need to turn on a light ...
(Date:10/13/2017)... ... October 13, 2017 , ... The International Association of ... of excellence for the field of eating disorders, announces the opening of early ... in Orlando, Florida at the Omni Resort at ChampionsGate. , The ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice ... of cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU ...
(Date:10/13/2017)... CT (PRWEB) , ... October 13, 2017 , ... ... long-term care services, staged a mock evacuation of the facility as part of a ... Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Hill-Rom Holdings, Inc. (NYSE: HRC), will host ... webcast on Friday, November 3, 2017, beginning at 7:00 ... approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... performance and guidance for 2018, Hill-Rom executives will also ... performance, and long-range financial outlook through 2020. ...
(Date:9/27/2017)... for their devotion to personalized service, SMP Pharmacy Solutions announces ... the South Florida Business Journal,s 50 Fastest-Growing Companies, and listed ... national specialty pharmacy has found its niche.  To that end, ... honored by SFBJ as the 2017 Power Leader in Health ... his award in October, Bardisa said of the three achievements, ...
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
Breaking Medicine Technology: