Navigation Links
Alzheimer's Drug May Someday Help Head Trauma Victims
Date:3/15/2009

Finding may prevent long-term harm that often follows brain injury, researcher says,,

SUNDAY, March 15 (HealthDay News) -- A new class of Alzheimer's disease drugs may prevent long-term damage from traumatic brain injury, suggests a study of mice by Georgetown University Medical Center researchers.

The drugs -- gamma-secretase inhibitors -- are designed to target amyloid plaque that accumulates in the brains of people with Alzheimer's disease, according to background information in the study.

"No one knows why it occurs, but abnormal amounts of amyloid plaque have been found during an autopsy in about a third of brain injury victims, some of whom were children who would ordinarily never have had these deposits," Mark Burns, a neuroscientist and assistant professor at Georgetown and the study's lead author, said in a university news release. "Remarkably, these deposits occur in less than one day after injury."

It's also known that people who've suffered a brain injury have a 400 percent increased risk of developing Alzheimer's disease, according to the researchers.

"In this study, we show that the same pathways activated chronically in Alzheimer's disease are activated acutely in traumatic brain injury and that they appear to play a very important role in secondary injury," Burns said.

He and his colleagues first conducted tests that showed that brain injury in mice resulted in substantially more amyloid peptide than normal. They then found that amyloid peptide production after brain injury was reduced in mice that received an experimental agent called DAPT, one of the first gamma secretase inhibitors developed and the basis for some Alzheimer's disease drugs now in clinical trials.

The researchers said that their findings, which are published online in Nature Medicine, suggest that this class of drugs could do something no other drug has been able to do -- prevent the long-term and continuing damage that often follows serious brain injury.

"This is an exciting finding that we hope can be readily tested in patients with traumatic brain injury," Burns said.

Georgetown University has applied for a patent for the technology involved in the research, the news release said.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about traumatic brain injury.



-- Robert Preidt



SOURCE: Georgetown University Medical Center, news release, March 15, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Alzheimers Research Target May Be a Dead End
2. Gene-Based Sunscreen Might Someday Prevent Skin Cancer
3. Researchers discover ways of integrating treatment of traumatized Tibetan refugee monks
4. Ecstasy could help patients with post-traumatic stress disorder
5. Nearly 1.4 Million Sustain Traumatic Brain Injuries Each Year
6. Oral and Maxillofacial Surgeons Applaud Congresswoman McCarthys Resolution Raising Awareness of Preventable Facial Trauma During Sports Activities
7. National Council on Disability Says More Needs to be Done for Service Members and Veterans With Post Traumatic Stress Disorder and Traumatic Brain Injury
8. Computer-aided system effectively detects and measures pneumothoraces in chest trauma patients
9. Incidental findings in trauma patients spark concerns for physicians
10. Post-Traumatic Stress Tied to Increased Suicide Risk
11. USMC Crime Scene Cleaners Draw On Iraq Experience as Biotrauma, Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Alzheimer's Drug May Someday Help Head Trauma Victims
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... healthcare compliance program management, will showcase a range of technology and learning solutions ... Living (NCAL) Convention and Expo to be held October 14–18, 2017 at the ...
(Date:10/12/2017)... New Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... fitness centers in the U.S., announced today its plans to open a flagship location ... club will occupy the former Rooms To Go store next to Office Depot in ...
(Date:10/12/2017)... PALM CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... of cold therapy products, announced today the introduction of an innovative new design of ... the multipurpose pad so you get maximum comfort while controlling your pain while using ...
(Date:10/12/2017)... ... , ... Asante, a nationally recognized health system in southern ... home health joint venture through an agreement, effective October 1, 2017, to create ... health company with Asante, delivering clinically integrated care, for the past eight years. ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... 2017   West Pharmaceutical Services, Inc. (NYSE: ... drug administration, today shared the results of a study ... the intradermal administration of polio vaccines. The study results ... May 2017 by Dr. Ondrej Mach , Clinical ... Organization (WHO), and recently published in the journal ...
(Date:10/5/2017)... 5, 2017  In response to the nationwide ... Maxillofacial Surgeons (AAOMS) released prescribing recommendations that urge ... used as a first-line therapy to manage a ... Recognizing the value and importance ... "Opioid Prescribing: Acute and Postoperative Pain Management" stresses ...
(Date:10/4/2017)... the Centers for Disease Control and Prevention (CDC), influenza vaccination should ... helping communities across Massachusetts , Connecticut ... shots through the end of the month. *Some exclusions apply ... ... is by the end of October, according to the Centers for Disease ...
Breaking Medicine Technology: