Navigation Links
Alzheimer's Drug May Someday Help Head Trauma Victims
Date:3/15/2009

Finding may prevent long-term harm that often follows brain injury, researcher says,,

SUNDAY, March 15 (HealthDay News) -- A new class of Alzheimer's disease drugs may prevent long-term damage from traumatic brain injury, suggests a study of mice by Georgetown University Medical Center researchers.

The drugs -- gamma-secretase inhibitors -- are designed to target amyloid plaque that accumulates in the brains of people with Alzheimer's disease, according to background information in the study.

"No one knows why it occurs, but abnormal amounts of amyloid plaque have been found during an autopsy in about a third of brain injury victims, some of whom were children who would ordinarily never have had these deposits," Mark Burns, a neuroscientist and assistant professor at Georgetown and the study's lead author, said in a university news release. "Remarkably, these deposits occur in less than one day after injury."

It's also known that people who've suffered a brain injury have a 400 percent increased risk of developing Alzheimer's disease, according to the researchers.

"In this study, we show that the same pathways activated chronically in Alzheimer's disease are activated acutely in traumatic brain injury and that they appear to play a very important role in secondary injury," Burns said.

He and his colleagues first conducted tests that showed that brain injury in mice resulted in substantially more amyloid peptide than normal. They then found that amyloid peptide production after brain injury was reduced in mice that received an experimental agent called DAPT, one of the first gamma secretase inhibitors developed and the basis for some Alzheimer's disease drugs now in clinical trials.

The researchers said that their findings, which are published online in Nature Medicine, suggest that this class of drugs could do something no other drug has been able to do -- prevent the long-term and continuing damage that often follows serious brain injury.

"This is an exciting finding that we hope can be readily tested in patients with traumatic brain injury," Burns said.

Georgetown University has applied for a patent for the technology involved in the research, the news release said.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about traumatic brain injury.



-- Robert Preidt



SOURCE: Georgetown University Medical Center, news release, March 15, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Alzheimers Research Target May Be a Dead End
2. Gene-Based Sunscreen Might Someday Prevent Skin Cancer
3. Researchers discover ways of integrating treatment of traumatized Tibetan refugee monks
4. Ecstasy could help patients with post-traumatic stress disorder
5. Nearly 1.4 Million Sustain Traumatic Brain Injuries Each Year
6. Oral and Maxillofacial Surgeons Applaud Congresswoman McCarthys Resolution Raising Awareness of Preventable Facial Trauma During Sports Activities
7. National Council on Disability Says More Needs to be Done for Service Members and Veterans With Post Traumatic Stress Disorder and Traumatic Brain Injury
8. Computer-aided system effectively detects and measures pneumothoraces in chest trauma patients
9. Incidental findings in trauma patients spark concerns for physicians
10. Post-Traumatic Stress Tied to Increased Suicide Risk
11. USMC Crime Scene Cleaners Draw On Iraq Experience as Biotrauma, Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Alzheimer's Drug May Someday Help Head Trauma Victims
(Date:5/28/2016)... ... ... city where’s it’s easy to spot the neon lights of chains serving fast food, one ... a taste for real food. , On May 13, the Best Western Plus ... restaurant focusing on dishes made by hand with wholesome, organic ingredients that are sourced locally ...
(Date:5/27/2016)... , ... May 27, 2016 , ... Two director-level employees ... YWCA Tribute to Women and Industry (TWIN) 2016 honorees. The award recognizes businesswomen ... For this year, Geri Boone, Director of the MLTSS (Managed Long-Term Services and Supports) ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... With over ... to walk, the demand for a sustainable product to aid in the rehabilitation process ... aid in the recovery of individuals with hemiplegia due to stroke. , Ekso Bionics ...
(Date:5/27/2016)... , ... May 27, 2016 , ... ... to help educate the many who are unaware of the plight of aphasia. ... will run within the “Stroke Awareness” campaign. , The link between stroke and ...
(Date:5/27/2016)... ... 27, 2016 , ... Aimed at nurses and employees in the health care ... leaders in the nursing and health care industry. It also provides insight to the ... University. , As the nursing industry is coming out of one of the ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 2016 The innovator of ... , s first dual therapy stent, introduces catheters ... OrbusNeich, a global company specializing in the provision ... include products to treat peripheral artery disease. The JADE™ ... devices for lower limb and arteriovenous (AV) fistula intervention. ...
(Date:5/24/2016)... , May 24, 2016 ... ™ , la première endoprothèse à ... destinés à l,intervention portant sur les membres ... OrbusNeich, entreprise mondiale spécialisée dans ... changer la vie, a élargi son portefeuille ...
(Date:5/24/2016)... Dutch surgeons have launched a ground-breaking medical app to help doctors ... a global scale. Medical professionals from Europe , ... the US have already signed up for the app, which combines ... environment. Education  "Imagine a doctor for Medicines ... at Harvard to treat a bomb victim via live streaming - ...
Breaking Medicine Technology: