Navigation Links
Alzheimer's Drug May Reduce Preemie Brain Injury
Date:6/24/2008

Memantine could protect newborns with compromised blood, oxygen supply, study suggests

TUESDAY, June 24 (HealthDay News) -- The Alzheimer's drug memantine (brand name Namenda) may help reduce a form of brain injury that affects many premature babies, according to a Children's Hospital Boston study.

Hypoxic-ischemia, a compromise of the brain's blood and oxygen supply, can lead to cerebral palsy and cognitive/behavioral problems.

In experiments with rats that had brain injury similar to that seen in some premature infants, the Children's Hospital team found memantine could reduce damage to cells called oligodendrocytes, which form the brain's white matter.

Memantine blocks a type of glutamate receptor in the brain called the NMDA receptor. In premature babies, hypoxic-ischemia leads to over-activation of NMDA receptors, resulting in a pattern of white-matter brain injury called periventricular leukomalacia (PVL).

"The premature brain is not just a 'small' adult brain -- it is physiologically different and thus contains unique targets for therapy," senior investigator Dr. Frances Jensen said in a prepared statement. "The NDMA receptor in white matter may be one of those targets. We tested this target in the animal model, and we also show that it is present in the premature human brain."

The findings may help lead to a protective therapy for preterm infants. Currently, no such protective therapy exists.

The study was published in the June 25 issue of the Journal of Neuroscience.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about PVL.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, June 24, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Alzheimers Research Target May Be a Dead End
2. Drug-Coated Stents Reduce Repeat Artery Procedures
3. New Report: Increasing Mississippis Cigarette Tax Will Reduce Smoking, Save Lives and Save Money
4. Gene silencer and quantum dots reduce protein production to a whisper
5. Newly approved ocular safety methods reduce animal testing
6. Study indicates grape seed extract may reduce cognitive decline associated with Alzheimers disease
7. Scientists from Granada drastically reduce the wait time for new teeth implant
8. Financial Incentives Could Improve Organ Donation and Reduce Donor-Recipient Gap
9. Racial disparities reduced in injury related mortality
10. Lifestyle Counseling Reduces Heart Risk
11. Data Show that Abbotts HUMIRA(R) (adalimumab) Reduced the Signs and Symptoms of Ankylosing Spondylitis Up to Three Years
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of ... ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership in ... It also provides a forum to network with elder law attorneys nationwide,” said Somekh. ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: ... “America On The Brink” is the creation of published author, William Nowers. ... As a WWII veteran, he spent thirty years in the Navy. Following ...
(Date:10/12/2017)... ... 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the ... new design of the shoulder pad. The shoulder pad provides optimal support and ... pain while using cold therapy. By utilizing ice and water that is circulated from ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare ... Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during ... , The annual award competition recognizes editorial and design excellence across a range of ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... Oct. 10, 2017  NDS received FDA 510(k) clearance in May ... battery-powered display stand specifically designed for endoscopy environments. An innovative secondary ... a clinical solution to support the improvement of patient outcomes, procedural ... ... ...
(Date:10/4/2017)... South Korea , Oct. 4, 2017  South ... its next-generation CPR training aide "cprCUBE" on Kickstarter. The ... chest compression during cardiac arrests with better efficiency compared ... It also offers real-time feedback on efficacy of the ... The crowdfunding campaign has a goal to raise $5,000. ...
(Date:10/2/2017)... 2, 2017  Eli Lilly and Company (NYSE: ... the third quarter of 2017 on Tuesday, October 24, ... that day with the investment community and media to ... conference call will begin at 9 a.m. Eastern time. ... live webcast of the conference call through a link ...
Breaking Medicine Technology: