Navigation Links
Alzheimer's Drug May Reduce Preemie Brain Injury
Date:6/24/2008

Memantine could protect newborns with compromised blood, oxygen supply, study suggests

TUESDAY, June 24 (HealthDay News) -- The Alzheimer's drug memantine (brand name Namenda) may help reduce a form of brain injury that affects many premature babies, according to a Children's Hospital Boston study.

Hypoxic-ischemia, a compromise of the brain's blood and oxygen supply, can lead to cerebral palsy and cognitive/behavioral problems.

In experiments with rats that had brain injury similar to that seen in some premature infants, the Children's Hospital team found memantine could reduce damage to cells called oligodendrocytes, which form the brain's white matter.

Memantine blocks a type of glutamate receptor in the brain called the NMDA receptor. In premature babies, hypoxic-ischemia leads to over-activation of NMDA receptors, resulting in a pattern of white-matter brain injury called periventricular leukomalacia (PVL).

"The premature brain is not just a 'small' adult brain -- it is physiologically different and thus contains unique targets for therapy," senior investigator Dr. Frances Jensen said in a prepared statement. "The NDMA receptor in white matter may be one of those targets. We tested this target in the animal model, and we also show that it is present in the premature human brain."

The findings may help lead to a protective therapy for preterm infants. Currently, no such protective therapy exists.

The study was published in the June 25 issue of the Journal of Neuroscience.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about PVL.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, June 24, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Alzheimers Research Target May Be a Dead End
2. Drug-Coated Stents Reduce Repeat Artery Procedures
3. New Report: Increasing Mississippis Cigarette Tax Will Reduce Smoking, Save Lives and Save Money
4. Gene silencer and quantum dots reduce protein production to a whisper
5. Newly approved ocular safety methods reduce animal testing
6. Study indicates grape seed extract may reduce cognitive decline associated with Alzheimers disease
7. Scientists from Granada drastically reduce the wait time for new teeth implant
8. Financial Incentives Could Improve Organ Donation and Reduce Donor-Recipient Gap
9. Racial disparities reduced in injury related mortality
10. Lifestyle Counseling Reduces Heart Risk
11. Data Show that Abbotts HUMIRA(R) (adalimumab) Reduced the Signs and Symptoms of Ankylosing Spondylitis Up to Three Years
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... May 04, 2016 , ... Dr. Elyson and Dr. Assili, ... surgery at their office. Wisdom tooth removal, a common dental procedure, is performed for ... often are improperly erupted, resulting in risks of complications. By providing wisdom tooth removal ...
(Date:5/4/2016)... Charlotte, NC (PRWEB) , ... May 04, 2016 , ... ... Charlotte, N.C., changed her life forever with a same-day LASIK procedure at ... to poor eyesight. Dr. Jonathan Christenbury performed her surgery the same day as her ...
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... ... all-LED multi-function small and compact tactical (6.7 inch) dual-light flashlights in models ... Vegas, model NSP-9842XL (average retail starting at $59.95) uses 2 included CR-123 batteries ...
(Date:5/4/2016)... ... May 04, 2016 , ... Warren L. Smith M.D. , ... called UTIs, have plagued people since the beginning of recorded medical history, and ... infections every year. It's not just a matter of inconvenience; bladder infections cost us ...
(Date:5/4/2016)... ... 04, 2016 , ... DESCO Medical Service, also known as ... sterilization service and sales company located in Pennsylvania. The terms of the deal ... asset management services to the medical and academic research industries. The acquisition will ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... Research and Markets has announced the addition ... Outlook 2020" report to their offering. ... has improved significantly in past years due to which ... years. Many cancer drugs have been developed by utilization ... expected to be developed with its help. They are ...
(Date:5/3/2016)... -- As a teenager, an active and athletic Randy ... heart. He continued enjoying sports and recreation throughout his ... was giving out and he was a few hours ... Mesa, Arizona resident received a ... transplant, the SynCardia TAH-t is the only approved device ...
(Date:5/3/2016)... , May 3, 2016   BIOTRONIK , ... today announced Food and Drug Administration (FDA) approval ... that provides heart failure patients with access to ... also have remote monitoring with daily automatic transmission ... heart rate in response to physiological demands. ...
Breaking Medicine Technology: