Navigation Links
Alzheimer's Drug May Reduce Preemie Brain Injury
Date:6/24/2008

Memantine could protect newborns with compromised blood, oxygen supply, study suggests

TUESDAY, June 24 (HealthDay News) -- The Alzheimer's drug memantine (brand name Namenda) may help reduce a form of brain injury that affects many premature babies, according to a Children's Hospital Boston study.

Hypoxic-ischemia, a compromise of the brain's blood and oxygen supply, can lead to cerebral palsy and cognitive/behavioral problems.

In experiments with rats that had brain injury similar to that seen in some premature infants, the Children's Hospital team found memantine could reduce damage to cells called oligodendrocytes, which form the brain's white matter.

Memantine blocks a type of glutamate receptor in the brain called the NMDA receptor. In premature babies, hypoxic-ischemia leads to over-activation of NMDA receptors, resulting in a pattern of white-matter brain injury called periventricular leukomalacia (PVL).

"The premature brain is not just a 'small' adult brain -- it is physiologically different and thus contains unique targets for therapy," senior investigator Dr. Frances Jensen said in a prepared statement. "The NDMA receptor in white matter may be one of those targets. We tested this target in the animal model, and we also show that it is present in the premature human brain."

The findings may help lead to a protective therapy for preterm infants. Currently, no such protective therapy exists.

The study was published in the June 25 issue of the Journal of Neuroscience.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about PVL.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, June 24, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Alzheimers Research Target May Be a Dead End
2. Drug-Coated Stents Reduce Repeat Artery Procedures
3. New Report: Increasing Mississippis Cigarette Tax Will Reduce Smoking, Save Lives and Save Money
4. Gene silencer and quantum dots reduce protein production to a whisper
5. Newly approved ocular safety methods reduce animal testing
6. Study indicates grape seed extract may reduce cognitive decline associated with Alzheimers disease
7. Scientists from Granada drastically reduce the wait time for new teeth implant
8. Financial Incentives Could Improve Organ Donation and Reduce Donor-Recipient Gap
9. Racial disparities reduced in injury related mortality
10. Lifestyle Counseling Reduces Heart Risk
11. Data Show that Abbotts HUMIRA(R) (adalimumab) Reduced the Signs and Symptoms of Ankylosing Spondylitis Up to Three Years
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2017)... ... February 20, 2017 , ... Today, Illuma ... plan partners, announced during the 2017 Annual HIMSS Conference & Exhibition ... for diabetic patients and integrating eye care into mainstream healthcare delivery is powered ...
(Date:2/19/2017)... ... February 19, 2017 , ... The Citadel’s new Swain Department ... being led by Amelia Joseph, Ph.D. Joseph was engaged by the college as a ... department in early 2016. After a nation-wide search, she was selected to head the ...
(Date:2/19/2017)... ... February 19, 2017 , ... ProBrand Glitch is a set of 30 glitch distortion logo reveals ... easily reveal any logo with a glitch reveal in just a few clicks of a ... and animation of each preset. Use these presets to add a uniquely animated logo to ...
(Date:2/19/2017)... ... February 19, 2017 , ... Orbita, ... join forces with Healthwise ® at HIMSS 2017 to showcase ... in evidence-based health education, technology and services, will demonstrate a voice-powered knowedge assistant ...
(Date:2/18/2017)... ... February 17, 2017 , ... Focused start-ups, not traditional health ... according to the recent NEJM Catalyst Insights Report on the New Marketplace. ... Insights Council, a qualified group of U.S. executives, clinical leaders, and clinicians at ...
Breaking Medicine News(10 mins):
(Date:2/18/2017)... CHAPEL HILL, N.C. , Feb. 17, 2017  Pharmaceutical ... medical insights about products either in development or already on ... requirements have forced the pharma industry to alter how it ... advisory boards, consulting leader Best Practices, LLC conducted a new ... boards. ...
(Date:2/17/2017)... Arvinas LLC, a private biotechnology company creating ... today announced the presentation of new preclinical data on ... session at the American Society of Clinical Oncology 2017 ... FL. "The new data ... potential of PROTACs to drive durable and robust responses ...
(Date:2/17/2017)... 2017 Research and Markets has announced the addition ... to their offering. ... provides separate comprehensive analytics for the US, Canada , ... Asia-Pacific , Latin America , and Rest of ... 2022. Also, a six-year historic analysis is provided for these markets. Market ...
Breaking Medicine Technology: