Navigation Links
'Alzheimer protein' seems to slow down neurotransmitter production
Date:8/21/2012

How abnormal protein deposits in the brains of Alzheimer's patients disrupt the signalling between nerve cells has now been reported by researchers in Bochum and Munich, led by Dr. Thorsten Mller from the Medizinisches Proteom-Center of the Ruhr-Universitt, in the journal Molecular and Cellular Proteomics. They varied the amount of APP protein and related proteins associated with Alzheimer's disease in cell cultures, and then analysed how this manipulation affected other proteins in the cell. The result: the amount of APP present was related to the amount of an enzyme that is essential for the production of neurotransmitters and therefore for communication amongst nerve cells.

Proteomics: analysing all the proteins of the cells at once

Amyloid plaques are a characteristic feature of Alzheimer's disease. They consist largely of cleavage products of the so-called amyloid precursor protein APP, which occur in excess in the brains of Alzheimer's patients. What role APP plays in healthy people and why the abnormal accumulation of amyloid disrupts the regular functioning of the brain is still largely unclear. To understand the function of APP, the RUB researchers established a new cell model. The new cells produced only a very small amount of APP. What impact this had on all the other proteins of these cells was examined by the researchers through the use of mass spectrometry, among other things. With this method they identified over 2000 proteins and determined their concentrations. They were looking specifically for molecules whose concentrations in the newly established low-APP cells were different than in the reference cells that contained normal amounts of APP.

Abnormal protein able to curb neurotransmitter production

"One candidate has particularly caught our attention, this being the enzyme methionine adenosyltransferase II, alpha, MAT2A for short", Thorsten Mller said. Among other things, the enzyme is
'/>"/>

Contact: Dr. Thorsten Mller
thorsten.t.mueller@rub.de
49-234-322-9265
Ruhr-University Bochum
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Rejected drug may protect against toxic substance common to Alzheimers and Parkinsons diseases
2. Blood test for Alzheimers gaining ground
3. Alzheimers Progression Slower After 80: Study
4. In Mice, Alzheimers-Linked Protein Shows Promise Against MS
5. Artificial butter flavoring ingredient linked to key Alzheimers disease process
6. Spice ingredient in curry emerges as promising basis for an Alzheimers disease medicine
7. Rejected Alzheimers drug shows new potential
8. Scientists Say Blood Test May Help Predict Alzheimers
9. Helping Alzheimers patients stay independent
10. Alzheimers Drug Shows Promise in Early Trial
11. Alzheimers Treatment Shows Promise in Small, 3-Year Trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... “We are proud to introduce the Pond Defender. It’s ... the U.S.,” says Shaun Johnson, Retail & Mass Merchant Sales ... to a very expensive problem, considering customers pay hundreds and ... , Each package of Pond Defender features twelve discs ... any water garden or pond. The discs create a ring ...
(Date:6/19/2013)... 2013 According to Transparency Market Research ... Trends, Analysis and Forecast, 2011 – 2017,” the global ... the year 2011 and is expected to reach USD ... 9.7% from 2011 to 2017. Flexible endoscopes formed the ... USD 2,201 million for the year 2011. , Related ...
(Date:6/19/2013)... have focused on two proteins that accumulate in the ... the disease: plaques made up of the protein amyloid-beta, ... for the first time, an Alzheimer,s researcher has looked ... the interaction of the two proteins with each other ... and in mouse brains with Alzheimer,s disease. The research ...
(Date:6/19/2013)... AquaPrint Solutions in Thomson, IL is proud ... a newly-designed Harley Davidson motorcycle gas tank. A couple of ... an idea of taking a split tank motorcycle that had ... it into a work of art. , In October ... toilet seats that had been dipped in a water transfer ...
(Date:6/19/2013)... 2013 The Cancer Support Community (CSC), ... cancer care for the whole patient with the launch ... Support Community. This inaugural event, held at the Newseum, ... Ph.D., recognition of Congress members who have made a ... patients and families currently engaged in the cancer journey. ...
Breaking Medicine News(10 mins):Health News:Endoscopy Devices Market Will Reach USD 10.8 Billion in 2017 : Transparency Market Research 2Health News:Endoscopy Devices Market Will Reach USD 10.8 Billion in 2017 : Transparency Market Research 3Health News:New Alzheimer's research suggests possible cause: The interaction of proteins in the brain 2Health News:AquaPrint Solutions Transforms Harley Davidson Gas Tank into a Work Of Art for Poopy’s Pub & Grub 2Health News:Keeping the Promise of Cancer Care for the Whole Patient 2Health News:Keeping the Promise of Cancer Care for the Whole Patient 3
... By Jenifer Goodwin HealthDay Reporter , FRIDAY, ... refer to themselves as "stroke centers of excellence" or ... top-notch care for stroke and heart attacks. But ... providers of the best cardiovascular or stroke care are ...
... Gordon HealthDay Reporter , FRIDAY, Nov. 12 (HealthDay ... grow, scientists have made significant discoveries in the past year ... blood sugar disease in its tracks. That,s ... Sunday. Created in 1991 as a joint project between the ...
... about a third of our lives asleep. So there must ... sleep helps consolidate memories, fixing them in the brain so ... that sleep also seems to reorganize memories, picking out the ... new and creative ideas, according to the authors of an ...
... , FRIDAY, Nov. 12 (HealthDay News) -- That ... Thanksgiving meal may be due to the fact that the ... study suggests. The researchers in the psychology department at ... had expected that seeing meat would make people more aggressive. ...
... Nov. 12 (HealthDay News) -- Patients with a certain type ... cancer was diagnosed saw their disease progress much faster and ... adequate vitamin D levels, a new study finds. Researchers ... linked to longer survival times, even after controlling for other ...
... recognized influenza pandemic originated in Asia and rapidly spread ... of 1510. A new commentary by researchers at the ... the National Institutes of Health, explores the 1510 pandemic ... controlling and treating influenza. Prior to that time, ...
Cached Medicine News:Health News:Setting National Hospital Standards Could Boost Cardiac Care 2Health News:Setting National Hospital Standards Could Boost Cardiac Care 3Health News:Diabetes Research Made Significant Strides in Past Year 2Health News:Diabetes Research Made Significant Strides in Past Year 3Health News:Sleep makes your memories stronger 2Health News:Sight of Meat Puts People at Ease, Study Suggests 2Health News:Low Vitamin D Linked to Deterioration in Certain Leukemia Patients 2
(Date:6/18/2013)... 18, 2013  Intercept Pharmaceuticals, Inc.  (NASDAQ: ... the development and commercialization of novel bile acid therapeutics ... of an underwritten public offering of 1,730,000 shares of ... $33.01 per share.  In addition, Intercept has granted the ... additional 259,500 shares of common stock. All ...
(Date:6/18/2013)... PROSPECT, Ill. , June 18, 2013 /PRNewswire-iReach/ ... of its new X3130 Appliance Inlet Module. The ... circuit breaker , combines a C14 appliance inlet ... one compact package.  This three-in-one device allows design ... their designs - cutting installation time by 66 ...
(Date:6/18/2013)... June 18, 2013  It has become apparent ... Seating and Mobility, a subsidiary company of The ... repair. This appears to be due to the ... field service employees.  (Logo: ... of these clients are complex mobility users with ...
Breaking Medicine Technology:Intercept Pharmaceuticals Announces Pricing of Public Offering of Common Stock 2Three-in-One X3130 Appliance Inlet Module 2
... Nov. 29, 2011 Uptake Medical® today announced the ... lung volume reduction in a patient with severe emphysema. ... endoscopic lung volume reduction system for the treatment of ... without leaving foreign materials in the lung. The patient ...
... IRVING, Texas, Nov. 29, 2011 A new study in ... has uncovered a novel mechanism that cancer cells may use ... "Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T ... Moffitt Cancer Center in Tampa, Fla., shows that a specific ...
Cached Medicine Technology:Uptake Medical Announces First Commercial Use of InterVapor for Patients With Severe Emphysema 2Uptake Medical Announces First Commercial Use of InterVapor for Patients With Severe Emphysema 3New Study Points to Novel Mechanism by Which Tumors Escape Recognition by the Immune System 2New Study Points to Novel Mechanism by Which Tumors Escape Recognition by the Immune System 3
The ReSeeVit Slit Lamp System is an easy-to-use digital video imaging system that captures anterior segment and retinal images for documentation, diagnosis and patient education. The package includes...
... The 2V slit ... style slit lamp that ... vertical illumination tower and ... 16X magnification. Revolutionary design ...
... ReSeeVit 3Z slit lamp is designed to ... video ready slit lamp offers the popular ... addition to the ReSeeVit family of slit ... the market to capture clear, crisp digital ...
... The first slit lamp truly designed from ... digital video imaging. No other slit lamp ... of this exceptional product. The ReSeeVit 5V ... on the market to allow capture of ...
Medicine Products: