Navigation Links
Alternative to Statins Shows Promise
Date:3/10/2010

Broader study needed to check for possible long-term effects, experts say,,

WEDNESDAY, March 10 (HealthDay News) -- A thyroid-derived cholesterol-lowering drug that could be an alternative to the widely used statin medications has done well in a small, early trial, Swedish and American researchers report.

In the trial, various doses of the drug, eprotirome, a laboratory-engineered version of thyroid hormone, were added to statin treatment for 168 people whose high levels of LDL cholesterol had not been lowered by previous use of statins. The combination did lower cholesterol levels in the 12-week trial and, most importantly, did not cause the feared side effects on the heart and other organs that have plagued similar thyroid-based treatments.

"There was no doubt that eprotirome would lower LDL cholesterol. Thyroid hormone is nature's own statin," said Dr. Paul W. Ladenson, a professor of endocrinology and metabolism at the Johns Hopkins University School of Medicine and lead author of a report on the trial, published in the March 11 issue of the New England Journal of Medicine. "But this is a demonstration of lipid-lowering effect without thyroid toxicity."

Dr. Bo Angelin, a professor of clinical metabolic research at the Karolinska Institute in Stockholm, where the drug was developed, said that the trial demonstrated that careful targeting of the drug's effect within the body could obtain the benefits of thyroid hormone on blood cholesterol levels, without causing damaging side effects. The trial was funded in part by Karo Bio, a small commercial spinoff of the institute.

"We knew that thyroid hormone could lower lipid [cholesterol] levels but would have side effects on the circulation and bones and cause diarrhea," Angelin said. "Even if the lipid levels were OK, it would be overall negative for patients."

However, he added, "if we can get the thyroid effect in the liver [where cholesterol is metabolized] but not in other organs, we would be OK."

Frequent monitoring showed no ill effects on the hearts and bones of those taking the drug, the report said.

And though statins are widely used and most often successful, an alternative to them would be welcome, Ladenson said. Statins are not effective in up to a quarter of potential users because of unacceptable muscle pain or simple failure to lower cholesterol levels, he said.

"The first importance of the trial is that it shows hepatic [liver] targeting of hormonal action," Ladenson said. "The second exciting part is its impact on lipids other than LDL cholesterol."

Though statins lower LDL ("bad") cholesterol, they have no effect on other blood fats, such as lipoprotein A, which is believed to be equally damaging, Ladenson said. He said that significant reductions of blood levels of those fats were seen in the trial.

Larger and longer studies are needed to determine whether eprotirome will have the hoped-for effect on blood fat levels without side effects and will ultimately reduce the risk of heart attacks and other cardiovascular diseases, both Ladenson and Angelin said, adding that such trials now are in the planning stages.

At best, results would not be available for "at least two to three years," Angelin said.

If eprotirome does pass all the anticipated tests successfully, its use at first probably would be in combination with a statin, Angelin said. Use as a single drug treatment for elevated cholesterol levels could follow, first in selected patients, then more widely, he said.

It's best to move cautiously, agreed Dr. Robert M. Califf, vice chancellor for clinical research at Duke University.

"The effects on LDL cholesterol and lipoproteins are pretty exciting," Califf said. "But if there is one thing we've learned about drugs in this arena, it's that we need large trials to see how they measure up in terms of risk and benefit."

The trial's researchers were careful to list indications of possible harmful side effects, such as a reduction in levels of HDL ("good") cholesterol, Califf said. But he echoed the thought that a longer-term and larger test is needed to determine the incidence of some possible major side effects, such as impotence.

"I'm not sure I'd want to sign up for that one before I had longer-term results," Califf said. "Being impotent is no fun."

More information

The American Heart Association has more on cholesterol-lowering drugs.



SOURCES: Paul W. Ladenson, M.D., professor, endocrinology and metabolism, Johns Hopkins University School of Medicine, Baltimore; Bo Angelin, M.D., Ph.D., professor, clinical metabolic research, Karolinska University, Stockholm, Sweden; Robert M. Califf, M.D., vice chancellor, clinical research, Duke University, Durham, N.C.; March 11, 2010, New England Journal of Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Data from Patient Subsets of e-HEALING, a Worldwide Registry, Support Use of OrbusNeichs Genous(TM) Bio-Engineered R Stent(TM) as Alternative to Drug- Eluting Stents
2. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
3. GladRags Introduces the Moon Cup - An Environmentally-Sound and Safe Alternative to Disposable Feminine Hygiene Products!
4. Trade-offs reveal no clear favorites in alternative energy market
5. Clinical trials present better alternatives for dialysis patients
6. New Technology at Unitrin Direct Gives Customers an Alternative to Waiting
7. Stem cells in adult testes provide alternative to embryonic stem cells for organ regeneration
8. Natural Alternatives International, Inc. Announces Late Filing of its Annual Report on Form 10-K, Revenue for Fiscal 2007 and Guidance on First Quarter of Fiscal 2008
9. After Infant Gripe Water Recall Scare, Homeopathic Medicine Offers Safe Alternative
10. Nosefrida Nasal Aspirator - A Parents Alternative to Medicines on the Verge of FDA Ban
11. Paramedics can provide an effective alternative to standard ambulance service in the community
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/24/2017)... Providenciales, Turks & Caicos Islands, BWI (PRWEB) , ... September 24, ... ... Caicos Islands, the #1 rated resort on TripAdvisor and one of Provo's premier boutique ... was no reported structural damage to the resort after devastating Hurricanes Irma and more ...
(Date:9/24/2017)... ... ... I”, a young boy was walking home and feeling down about himself. He didn’t think ... new friend says he can do whatever he wants to do if he puts his mind ... he is. God created him with special talents and gifts. We see his internal dialogue ...
(Date:9/23/2017)... ... September 23, 2017 , ... ... to fighting obesity of Robert Kushner, director of Chicago’s Center for Lifestyle Medicine ... promoting healthier habits, the article notes that the center routinely recommends weight loss ...
(Date:9/22/2017)... ... 2017 , ... MEDIA OPPORTUNITY: , Save Our Hospital - Albert Lea will ... are rallying against Mayo Clinic. Specifically, media can talk to steering committee members and ... to close the Albert Lea hospital. , The rally aims to protect the most ...
(Date:9/22/2017)... ... 2017 , ... Fenwick Agency of Plano, TX has announced the commencement of ... the nationally recognized ‘Agents of Change’ movement. The agency pledges to select a new ... seek out those who most need help. Their hope is to bring awareness to ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... -- Robert G. Szewc, M.D., is recognized by Continental Who,s ... his contributions to the Medical field.      ... practice of Kidney and Hypertension Specialists, which specializes in ... He has worked in this position since 2002, and ... as expertise in kidneys, hypertension, chronic disease and anemia, ...
(Date:9/6/2017)...   PDI , a leader in infection prevention ... educational session focused on the role of chlorhexidine gluconate ... the 2017 Annual Scientific Meeting of the Association for ... the Phoenix Convention Center in ... will also feature PDI,s Prevantics® Device Swab ...
(Date:9/6/2017)... Sept. 6, 2017 Eli Lilly and Company ... present new data for galcanezumab and lasmiditan, two investigational ... International Headache Society (IHC) taking place Sept. 7-10 in ... will highlight new, long-term data from an open-label study ... galcanezumab (120 mg and 240 mg) for the prevention ...
Breaking Medicine Technology: