Navigation Links
Alternating mammography and MRI may be best for high-risk women
Date:12/13/2008

SAN ANTONIO - Magnetic resonance imaging (MRI) alternated with mammography at six-month intervals can detect breast cancers not identified by mammography alone, a research team from The University of Texas M. D. Anderson Cancer Center will report at the 31st at the CRTC-AACR San Antonio Breast Cancer Symposium.

MRI is known to be more sensitive in detecting breast cancers than mammography, with a 71 - 100 percent accuracy compared to a 16 - 40 percent accuracy for mammography. As a result, annual breast cancer screening for high-risk women now typically includes MRI along with mammography and a clinical breast exam.

"In the high-risk population, the recent standard of practice is to perform mammography and MRI every year," said Huong Le-Petross, M.D., assistant professor of diagnostic radiology at M. D. Anderson and the study's first author. "What we started to do at M. D. Anderson was to see if we could do mammography and then six months later do a breast MRI exam, followed six months later with a mammogram exam, and then six months after that with a breast MRI. That way the women would receive an imaging modality screening every six months."

In the pilot study, to be presented at a poster session on Dec. 13, the researchers performed a retrospective chart review of 334 women who had participated in a high-risk breast cancer-screening program at M. D. Anderson from Jan. 1997 to Dec. 2007. The women had undergone between one and four MRI screening cycles and were considered to be at high risk if they had hereditary breast and ovarian cancer syndrome, a personal history of breast cancer, a biopsy indicating atypia or lobular carcinoma in situ (LCIS), or a 20 percent or higher lifetime risk of developing breast cancer, as estimated by the Gail model.

In the all-M. D. Anderson study, 86 of the 334 high-risk women (26 percent) underwent this alternating approach. Among this group, 46 percent completed the first round of MRI screening, 28 percent completed the second round, 13 percent completed the third round, and 4 percent completed the fourth round. The other 248 women underwent prophylactic mastectomy or were started on chemoprevention agents. All study participants were given a clinical breast exam every six months. The median follow-up time was 2 years, with a range of one to four years).

The alternating MRI and mammography screening program detected nine cancers among the 86 women-five invasive ductal carcinomas, three invasive lobular carcinoma, and two ductal carcinomas in situ. Five (55 percent) of these cancers were identified by MRI but not by mammography, three (33 percent) were found by both MRI and mammography, and one (11 percent) cancer, a tumor one millimeter in size, was overlooked by both screening techniques. No cancer was detected by mammography alone.

"We found that MRI picked up the majority of cancers, while mammography picked up only three out of the nine," Le-Petross noted. With five of the eight cancers detected by MRI, the mammogram from six months earlier was either normal or suggested benign findings.

"The global picture is that MRI can pick up cancers that mammography cannot," Le-Petross said. "This would suggest that in this population it is more beneficial for the patient to have screening MRI so that we can pick up small lesions before a mammogram can detect them."

One important unanswered question is whether an alternating MRI and mammography screening program will save lives. "That is going to take a 5- to 10-year follow-up to determine," Le-Petross added. "It is an exciting question because mammography has always been the standard, and now we are challenging that gold standard examination."


'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
832-264-8893
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Related medicine news :

1. Molecular Breast Imaging Has Greater Sensitivity Over Mammography, Ultrasound and MRI for Invasive Lobular Carcinoma
2. New mammography technology effective in detecting breast cancer
3. Breast cancer in men: Mammography and sonography findings
4. Dual-head gamma camera increases ability to detect breast tumors not seen on mammography
5. DEP Releases Third Quarter Mammography Inspections
6. Convenience of screening mammography facilities plays major role in patient retention
7. iCAD Achieves Record-High Ratings in Mammography CAD User Satisfaction
8. Advanced Digital Mammography System Comes to Vacaville
9. Adding ultrasound screening to mammography brings benefits, risks
10. Coupled With Mammography, Ultrasound Finds More Breast Cancers
11. Women 80 and older benefit from mammography, but few are screened
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Alternating mammography and MRI may be best for high-risk women
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
(Date:6/24/2016)... ... ... Comfort Keepers® of San Diego, CA is excited to announce they are ... drive cancer patients to and from their cancer treatments. Comfort Keepers provides quality ... and ongoing independence. Getting to and from medical treatments is one of the ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, affiliated ... Weintraub as a prominent plastic surgeon and the network’s newest partner. , ... most handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... VIEW, Calif. , June 23, 2016 ... a.m. CST on Thursday, July 7, 2016 , , , ... kayla.belcher@frost.com ) , , , , EXPERT PANELISTS:  , ... Nitin Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa ... The global pharmaceutical industry is witnessing an ...
(Date:6/23/2016)... June 23, 2016  Guerbet announced today that it ... Supplier Horizon Award . One of 12 ... recognized for its support of Premier members through exceptional ... excellence, and commitment to lower costs. ... recognition of our outstanding customer service from Premier," says ...
(Date:6/23/2016)... YORK , June 23, 2016 ... waters, but it continues to present great opportunities to ... companies for today: Intrexon Corp. (NYSE: XON ... Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), and ... more about these stocks and receive your complimentary trade ...
Breaking Medicine Technology: