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Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas
Date:9/10/2007

provide strong support for a model that considers alteration of both coding and noncoding RNAs in the initiation and progression of human cancer. We found that noncoding UCRs are consistently altered at the genomic level in a high percentage of leukemias and carcinomas and may interact with miRNAs. The findings provide support for a model in which both coding and noncoding genes are involved in and cooperate in human tumorigenesis, concludes Dr. Croce. Further research is needed to investigate the complex functional interactions between multiple types of noncoding RNAs.


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Contact: Nancy Wampler
nwampler@cell.com
617-386-2121
Cell Press
Source:Eurekalert

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