Navigation Links
Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas
Date:9/10/2007

A new study provides evidence that noncoding RNAs and interactions between noncoding genes play a much greater role in human cancer than was previously understood. The research, published by Cell Press in the September issue of the journal Cancer Cell, may be useful for identifying tumor-specific signatures associated with diagnosis, prognosis, and treatment of cancer.

Malignant cells exhibit genetic alterations in oncogenes or tumor suppressor genes. More recently, a large class of noncoding RNA transcripts called microRNAs (miRNAs) has also been included in the genetic signature of cancer. MicroRNAs are small RNAs that can regulate gene expression by inhibiting protein translation, and recent research has implicated miRNAs in cancer initiation and progression.

Dr. Carlo M. Croce from Ohio State University, Dr. Massimo Negrini from the University of Ferrara, Italy, and colleagues investigated the role of additional classes of highly conserved noncoding RNAs in human cancer that have not been studied to the extent of miRNAs. This research will offer new insights into the molecular mechanisms and signal transduction pathways altered in cancer and may present opportunities for the identification of new molecular markers and potential therapeutic agents, explains Dr. Croce.

Using genome-wide profiling in a large panel of normal and cancer samples, the researchers discovered that genomic ultraconserved regions (UCRs) encode a particular set of noncoding RNAs whose expression is altered in human leukemias and carcinomas. These UCRs are highly conserved among different species, and although they do not encode proteins, they are likely to be functional. Inhibition of an overexpressed UCR induced apoptosis in colon cancer cells. Interestingly, the researchers also identified a functional role of miRNAs in the transcriptional regulation of UCRs associated with cancer.

Taken together with the current knowledge of miRNAs, these results
'/>"/>

Contact: Nancy Wampler
nwampler@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Women With Anorexia Have Altered Brain Activity
2. Tooth Decay Bacteria Unaffected By Altered Biochemical Pathway
3. Cocaine Acts As Suppressant Not Stimulant In Genetically Altered Mice
4. Schizophrenia Complicates With Altered Receptor Activity
5. The Immune System May Be Altered By Certain Chemicals
6. Altered Sodium Channel Function Linked to Heart Failure
7. Gene-Altered Foods ? Still Not Sure
8. Gene-Altered Foods -Still Not Sure
9. Genetically Altered Cells Prevent Lethal Infections in Substituted Skin
10. Altered Protein Structure was Found in Autism Patients
11. Penguins Altered Diet When Humans Began Hunting Whales and Seals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... first genetic variant specifically associated with the risk ... 10-15 per cent of all breast cancer cases. ... cancer sub-type, called invasive lobular carcinoma, gives researchers ... particular kind of breast cancer, which can be ... (Thursday) in the journal PloS Genetics , ...
(Date:4/17/2014)... the University of California, San Diego School of Medicine ... have suffered a recent major loss are more likely ... , The study is published in this month,s issue ... , Because compassionate behaviors are associated with better health ... insights into ways to improve the outcomes of individuals ...
(Date:4/17/2014)... 17, 2014U.S. military personnel who served in Iraq ... traumatic brain injury (TBI) were compared to military ... medical reasons. Differences in measures of overall disability, ... after injury are reported in an article in ... from Mary Ann Liebert, Inc., publishers. The article ...
(Date:4/17/2014)... a new mechanism that allows blood to enter the ... and the Salk Institute have opened the door to ... damage. , A complex and devastating neurological condition, stroke ... for disability in the U.S. The blood-brain barrier is ... into the brain, causing the permanent deficits in movement ...
(Date:4/17/2014)... international research team led by Cesar A. Arias, M.D., ... at Houston (UTHealth) has identified a new superbug that ... report appeared in the April 17 issue of ... new superbug is part of a class of highly-resistant ... MRSA, which is a major cause of hospital and ...
Breaking Medicine News(10 mins):Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:The ilk of human kindness 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2Health News:New MRSA superbug emerges in Brazil 2
... at the Swedish medical university Karolinska Institutet have discovered ... inflammatory substances in their brains. Their findings offer hope ... affect the immune system. The causes of ... of effective treatments. One theory is that infections caught ...
... stimulates collagen production in fibroblasts and hepatic stellate ... the development of liver fibrosis. Hepatoprotective effects of ... induced liver fibrosis were reported in many studies. ... dimethylnitrosamine (DMN)-induced models has not been studied. ...
... or stall carotid artery disease , WEDNESDAY, Nov. 18 ... no additional benefit to seniors with coronary artery disease ... say. , The 18-month study of 145 Baltimore-area men ... in arterial wall thickness reductions between those who took ...
... quickly is critical, experts say , WEDNESDAY, Nov. 18 ... and communities in new guidelines for treatment of coronary ... should have an organized system of emergency care for ... they get to hospitals and strategies for getting ...
... , ... of the StreetSmarts® sales knowledge sharing platform and ELA’s sales expertise offers a winning ... ... Inc., developer of the on-demand sales effectiveness , knowledge and collaboration ...
... , LONDON, Nov. 18 XL Insurance, the global insurance ... today announced the strengthening of its equine capabilities with the ... Underwriting Limited ("Unicorn"), a subsidiary of THB Group plc. ... who has over 20 years of underwriting experience in the ...
Cached Medicine News:Health News:Immune system activated in schizophrenia 2Health News:Niacin Adds No Benefit for Statin Patients: Study 2Health News:New Heart Attack Treatment Guidelines Stress Coordination 2Health News:New Heart Attack Treatment Guidelines Stress Coordination 3Health News:StreetSmarts and ELA Consulting Group Forge Sales Effectiveness Partnership 2Health News:StreetSmarts and ELA Consulting Group Forge Sales Effectiveness Partnership 3Health News:StreetSmarts and ELA Consulting Group Forge Sales Effectiveness Partnership 4Health News:XL Insurance Strengthens Equine Underwriting Team 2
(Date:1/15/2014)... , Jan. 15, 2014  Echo Therapeutics, Inc. (Nasdaq: ... developing its Symphony® CGM System as a non-invasive, wireless ... F. Doman , Executive Chairman and Interim CEO of ... Markets, Tenth Annual Equity Conference. Mr. ...
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com ... is available in its catalogue: ... Drug Forecast and Market Analysis to 2022 ... PharmaPoint: Atopic Dermatitis - India Drug Forecast ...
(Date:1/15/2014)... , Jan. 15, 2014  Zafgen, Inc., a ... needs of severely obese patients, today announced initial ... a selective inhibitor of methionine aminopeptidase 2 (MetAP2), ... form of genetic obesity.  These results showed improvements ...
Breaking Medicine Technology:Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4
... Sept. 3 Forest Laboratories, Inc.,(NYSE: ... announced results from,two global Phase III studies ... for the treatment of patients with chronic,obstructive ... I&II,(AClidinium CLinical Trial Assessing Efficacy and Safety ...
... Efficacy ... Endpoints, Company to Host Conference Call and Webcast Wednesday, September ... 8:30 am ET ... NBIX ) today announced positive safety and efficacy results,from its third Phase II clinical ...
Cached Medicine Technology:Phase III Clinical Studies of Aclidinium Bromide Show Statistical Significance vs. Placebo in Patients With Chronic Obstructive Pulmonary Disease (COPD) 2Phase III Clinical Studies of Aclidinium Bromide Show Statistical Significance vs. Placebo in Patients With Chronic Obstructive Pulmonary Disease (COPD) 3Phase III Clinical Studies of Aclidinium Bromide Show Statistical Significance vs. Placebo in Patients With Chronic Obstructive Pulmonary Disease (COPD) 4Phase III Clinical Studies of Aclidinium Bromide Show Statistical Significance vs. Placebo in Patients With Chronic Obstructive Pulmonary Disease (COPD) 5Phase III Clinical Studies of Aclidinium Bromide Show Statistical Significance vs. Placebo in Patients With Chronic Obstructive Pulmonary Disease (COPD) 6Neurocrine Biosciences Announces Successful Elagolix PETAL Study in Endometriosis 2Neurocrine Biosciences Announces Successful Elagolix PETAL Study in Endometriosis 3Neurocrine Biosciences Announces Successful Elagolix PETAL Study in Endometriosis 4Neurocrine Biosciences Announces Successful Elagolix PETAL Study in Endometriosis 5Neurocrine Biosciences Announces Successful Elagolix PETAL Study in Endometriosis 6
A convenient, rotating standholds up to seven Gilson pipettes (any model) with exceptional stability. Protects your precious pipettes from possible damage or contamination....
Inquire...
... solution for scheduling, performing and documenting ... pipettes and liquid handling devices. Collects ... Supports all gravimetric calibration protocols ... NCCLS and GLP requirements Includes ...
... V-shaped bottom allows easy withdrawal of solution ... bag ,• Corner pouring lips facilitate ... designed for 4, 8, and 12 channel ... withdrawal of practically all of the solution. ...
Medicine Products: