Navigation Links
Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas
Date:9/10/2007

A new study provides evidence that noncoding RNAs and interactions between noncoding genes play a much greater role in human cancer than was previously understood. The research, published by Cell Press in the September issue of the journal Cancer Cell, may be useful for identifying tumor-specific signatures associated with diagnosis, prognosis, and treatment of cancer.

Malignant cells exhibit genetic alterations in oncogenes or tumor suppressor genes. More recently, a large class of noncoding RNA transcripts called microRNAs (miRNAs) has also been included in the genetic signature of cancer. MicroRNAs are small RNAs that can regulate gene expression by inhibiting protein translation, and recent research has implicated miRNAs in cancer initiation and progression.

Dr. Carlo M. Croce from Ohio State University, Dr. Massimo Negrini from the University of Ferrara, Italy, and colleagues investigated the role of additional classes of highly conserved noncoding RNAs in human cancer that have not been studied to the extent of miRNAs. This research will offer new insights into the molecular mechanisms and signal transduction pathways altered in cancer and may present opportunities for the identification of new molecular markers and potential therapeutic agents, explains Dr. Croce.

Using genome-wide profiling in a large panel of normal and cancer samples, the researchers discovered that genomic ultraconserved regions (UCRs) encode a particular set of noncoding RNAs whose expression is altered in human leukemias and carcinomas. These UCRs are highly conserved among different species, and although they do not encode proteins, they are likely to be functional. Inhibition of an overexpressed UCR induced apoptosis in colon cancer cells. Interestingly, the researchers also identified a functional role of miRNAs in the transcriptional regulation of UCRs associated with cancer.

Taken together with the current knowledge of miRNAs, these results provide strong support for a model that considers alteration of both coding and noncoding RNAs in the initiation and progression of human cancer. We found that noncoding UCRs are consistently altered at the genomic level in a high percentage of leukemias and carcinomas and may interact with miRNAs. The findings provide support for a model in which both coding and noncoding genes are involved in and cooperate in human tumorigenesis, concludes Dr. Croce. Further research is needed to investigate the complex functional interactions between multiple types of noncoding RNAs.


'/>"/>

Contact: Nancy Wampler
nwampler@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Related medicine news :

1. Women With Anorexia Have Altered Brain Activity
2. Tooth Decay Bacteria Unaffected By Altered Biochemical Pathway
3. Cocaine Acts As Suppressant Not Stimulant In Genetically Altered Mice
4. Schizophrenia Complicates With Altered Receptor Activity
5. The Immune System May Be Altered By Certain Chemicals
6. Altered Sodium Channel Function Linked to Heart Failure
7. Gene-Altered Foods ? Still Not Sure
8. Gene-Altered Foods -Still Not Sure
9. Genetically Altered Cells Prevent Lethal Infections in Substituted Skin
10. Altered Protein Structure was Found in Autism Patients
11. Penguins Altered Diet When Humans Began Hunting Whales and Seals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... , ... TLC Laser Eye Centers announced today that it has acquired Gordon ... be called “Gordon Schanzlin New Vision Institute, a TLC Laser Eye Center.” , ... ensure that patients continue to receive the highest quality of care. In addition, all ...
(Date:5/5/2016)... ... 05, 2016 , ... LELO has discovered many people are insecure ... out via email, social media and on the Volonté blog seeking advice about how ... masturbate ‘normal’ or ‘correct’?” , While some methods are more common than others, there ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... master charity program created to assist the people of their local community. The ... nonprofit organizations and community leaders. Their hope is to bring awareness to important ...
(Date:5/5/2016)... ... May 05, 2016 , ... Vitenas Cosmetic Surgery has ... Awards, presented by the American Institute of Architects and the Academy of Architecture for ... renowned Perkins+Will and Harrell Architects, opened to patients in October of 2014. ...
(Date:5/5/2016)... ... 2016 , ... Sun Health registered nurse Brittany Eads and ... Care Transitions program at the 9th Annual Orthopedic and Spine Summit held ... Post-Acute Environment Through Effective Transitions of Care.” , Major changes are taking place ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... Progra m m e ... Oxitec , s mosquito in Cayman Islands ... by 96 %   Oxitec and the Cayman ... wild Aedes aegypti, the dangerous mosquito that spreads dengue, Zika and ... Grand Cayman .  MRCU, a global leader in mosquito control, is ...
(Date:5/5/2016)... , May 5, 2016 /PRNewswire/ ... announced the addition of the  "Europe ... - 2016"  report to their offering.  ... ) , ,The latest research ... Highlights - 2016, provides comprehensive insights ...
(Date:5/4/2016)... May 4, 2016  Compass Diversified Holdings (NYSE: ... an owner of leading middle market businesses, announced today ... March 31, 2016. First Quarter 2016 Highlights ... Reinvestment ("CAD" or "Cash Flow") of $13.6 million for ... loss of $15.0 million for the first quarter of ...
Breaking Medicine Technology: