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Alterations in the brain's reward system related to attention-deficit/hyperactivity disorder
Date:2/3/2010

Until now, attention-deficit/hyperactivity disorder (ADHD) was related to alterations in the brain affecting attention and cognitive processes. Researchers at Universitat Autnoma de Barcelona and the Vall d'Hebron University Hospital for the first time have discovered anomalies in the brain's reward system related to the neural circuits of motivation and gratification. In children with ADHD, the degree of motivation when carrying out an activity is related to the immediacy with which the objectives of the activity are met. This would explain why their attention and hyperactivity levels differ depending on the tasks being carried out.

Susanna Carmona, researcher at the Cognitive Neuroscience Unit of the UAB Department of Psychiatry and Legal Medicine (URNC-IAPS-Hospital del Mar), has worked in collaboration with clinical researchers of the Vall d'Hebron University Hospital on the first research which relates the structure of the brain's reward system, the ventral striatum, with clinical symptoms in children suffering from ADHD.

Models describing the origin of ADHD tend to emphasise the relevance of attention processes and of the cognitive functions which guide our mental processes in achieving proposed objectives. Nevertheless, recent research has focused on neural gratification/pleasure circuits, which can be found in what is known as the brain's reward system, with the nucleus accumbens as the central part of this system.

The nucleus accumbens is in charge of maintaining levels of motivation when commencing a task and continues to do so until reaching what experts name the "reinforcement", the proposed objective. This motivation can be maintained throughout time, even when the gratification obtained is not immediate. However, in children with ADHD motivational levels seem to drop rapidly and there is a need for immediate reinforcements to continue persisting in their efforts.

In this study, researchers selected a sample o
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Contact: Maria Jesus Delgado
MariaJesus.Delgado@uab.cat
34-935-814-049
Universitat Autonoma de Barcelona
Source:Eurekalert

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