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Also in the Nov. 25 JNCI
Date:11/25/2008

ing examinations, suggesting that mammography exposure is not a major influence on increased risk of advanced disease.

"Our results suggest that postmenopausal women who are overweight or obesea large proportion in the United States (58% of women in our study)should be encouraged to lose weight and to undergo routine screening mammography, two factors that may decrease the number of women who are diagnosed with advanced disease," the authors conclude.

Contact: Steve Tokar, steve.tokar@ncire.org, (415) 221-4810 x5202


Reduced DNA Methylation Associated with Poorer Survival in Colon Cancer Patients

DNA hypomethylation in colon cancer tumors is associated with poorer patient survival.

DNA hypomethylation activates silenced genes and is associated with genomic instability and the development of colorectal cancer.

To find out if hypomethylation is associated with patient survival in colon cancer, Shuji Ogino, M.D., Ph.D., of Dana-Farber Cancer Institute and Harvard Medical School in Boston and colleagues measured the level of tumor DNA methylation in a section of DNA containing repetitive sequences that are normally methylated, called long interspersed nucleotide element-1 (LINE-1), and compared it with survival in 643 patients. Patients were identified from two prospective cohorts, the Nurses' Health Study and the Health Professionals Follow-up Study.

Patients whose tumor DNA had less methylation had a statistically significant increase in colon cancerspecific mortality and overall mortality.

"The results from this large prospective cohort study suggest that genome-wide DNA hypomethylation as measured in LINE-1 is independently associated with poor survival among patients with colon cancer," the authors conclude.

Contact: Bill Schaller, William_Schaller@dfci.harvard.edu, (
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Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

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