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Also in the Nov. 25 JNCI
Date:11/25/2008

ary factors and disease," the editorialists conclude. "Only when multiple studies with different designs in diverse populations produce consistent, robust results, can the evidence regarding an association be sufficiently persuasive."

Contact:
Article: Holly Brown-Ayers, hbrown-ayers@partners.org, (617) 534-1603
Editorial: National Cancer Institute press officers, ncipressofficers@mail.nih.gov, (301) 496-6641


Mammography Use and Accuracy Not Associated with Breast Cancer Risk in Overweight and Obese Postmenopausal Women

Patterns of mammography use and mammography accuracy are not the primary reasons for the increased risk of breast cancer or advanced breast cancer diagnosis in overweight and obese postmenopausal women relative to normal weight women in a large prospective study.

Obese and overweight women are at greater risk of postmenopausal breast cancer. The reasons for that increased risk are not understood.

To determine whether decreased mammography accuracy or use among overweight and obese women influenced breast cancer risk, Karla Kerlikowske, M.D., of the San Francisco Veterans Affairs Medical Center and colleagues analyzed data from seven mammography registries that participate in the Breast Cancer Surveillance Consortium. A total of 287,115 postmenopausal women not using hormone therapy underwent 614,562 mammography exams during 1996�, and 4,446 women were diagnosed with breast cancer.

Overweight and obese women had a statistically significantly increased rate of breast cancer and advanced breast cancer, compared with normal weight women, after taking into account patterns of mammography use and accuracy. Higher rates of advanced-stage breast cancer were observed in overweight and obese women compared with normal weight women for any given length of time between screen
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Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

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