Navigation Links
Also in the May 27 JNCI
Date:5/27/2008

d better disease-free survival compared with patients treated with standard therapy alone, according to the final results from a randomized phase III trial.

Paclitaxel and other taxanes are among the most active agents in metastatic breast cancer. Researchers are now testing the drugs in patients with early, non-metastatic breast cancer.

In the current study, Miguel Martn, M.D., of the Spanish Breast Cancer Research Group and colleagues randomly assigned 1,246 women to treatment with fluorouracil, epirubicin, and cyclophosphamide (FEC) or FEC followed by weekly paclitaxel (FEC-P).

The estimated 5-year survival rate was 78.5 percent in the FEC-P arm and 72.1 percent in the FEC arm. There was a trend toward improved overall survival, but it did not reach statistical significance. Because distant relapse-free survival is usually associated with overall survival, a statistically significant benefit in overall survival may become evident with a more protracted follow-up, the authors write.

A retrospective analysis of the data failed to detect a subgroup of patients who were more likely to respond to taxane therapy on the basis of their tumors expression of the estrogen receptor and HER2.

In an accompanying editorial, Clifford Hudis, M.D., and Chau Dang, M.D., of Memorial Sloan-Kettering Cancer Center in New York review several trials that tested the potential benefit of adding taxanes to existing adjuvant therapy. From that point of view, the study by Martn and colleagues is important because it is well designed and uses a good regimen and schedule of drugs.

They emphasize that retrospective analyses should be considered hypothesis generating only, particularly when the results from several similar analyses are inconsistent If you accept that the taxanes are effective, hormone receptor and HER2 status should not routinely guide your selection of patients for this therapy, the editorialists conclude.

Conta
'/>"/>

Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2 3 4

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... 2014) -- A group of scientists from the ... Sanders-Brown Center on Aging has found interesting new ... function in Parkinson,s disease (PD). , Published ... study, which assessed cognitive function in depressed and ... replacement therapy commonly used to treat motor symptoms ...
(Date:4/18/2014)... made a discovery that turns 160 years of neuroanatomy ... long known to be essential for the fast transmission ... not as ubiquitous as thought, according to a new ... Stem Cell Institute (HSCI) and the University,s Department of ... Jeff Lichtman, of Harvard,s Department of Molecular and Cellular ...
(Date:4/18/2014)... Benaroya Research Institute at Virginia Mason (BRI) recently received ... in metastatic breast cancer reduces both the growth of ... scientists have found in models of the disease that ... 80 percent and can keep the tumor from metastasizing ... grant comes from the National Cancer Institute of the ...
(Date:4/18/2014)... release is available in French . ... revolutionize surgical practice and regenerative medicine. A team led ... Chimie (CNRS/ESPCI Paris Tech) and Didier Letourneur from the ... 13), has just demonstrated that the principle of adhesion ... vivo to repair soft-tissue organs and tissues. This easy-to-use ...
(Date:4/17/2014)... non-cancerous prostate tissue may have nearly twice the risk ... inflammation, according to results of a new study led ... , The link between persistent inflammation and cancer was ... those with a Gleason score between 7 and ... and rapidly growing prostate cancers. , "What we,ve shown ...
Breaking Medicine News(10 mins):Health News:Treating depression in PD patients: New research 2Health News:Finding turns neuroanatomy on its head 2Health News:Finding turns neuroanatomy on its head 3Health News:Benaroya Research Institute evaluates immunology approach to blocking breast cancer 2Health News:Innovative strategy to facilitate organ repair 2Health News:Innovative strategy to facilitate organ repair 3Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3
... ... California, which provides health coverage to over 3 million Southern California residents, announced today ... to selected members who are struggling to lose weight. , , ... (PRWEB) April 12, 2010 -- ...
... ... of Tampa, FL has announced the formation of a charitable organization to benefit people of ... Odom,s team will include Tampa urologist Howard Heidenberg, a specialist in male fertility issues, ... ...
... ... we all need it. Unfortunately, for many, it seems that life just gets in the way; ... For 27 year old Helen Smailes from Keighley in the UK these were just some of ... she is happier and healthier than ever. , ...
... analysis has found that a considerable proportion of ... benefit from palliative radiation therapy (radiotherapy) despite spending ... early online in CANCER , a peer-reviewed ... indicates that greater efforts are needed to tailor ...
... SUNDAY, April 11 (HealthDay News) -- It,s easy to help your ... to the Alliance for a Healthier Generation. , For starters, join ... And you can share the fun and health benefits, too. ... to get on their bicycles, roller skates or blades and scooters. ...
... Khanna ... April 25. , ... 10, 2010 -- The Khanna institute to attend the YHC Health Expo on April 25th ... , , ,Khanna Institute of LASIK & Refractive surgery, an eye surgery center that caters ...
Cached Medicine News:Health News:Kaiser Permanente Southern California to Offer FitOrbit Online Personal Training to Targeted Patients 2Health News:Kaiser Permanente Southern California to Offer FitOrbit Online Personal Training to Targeted Patients 3Health News:Tampa Civil Attorney Gene Odom Announces Fertility Charity Partnership with Board Certified Male and Female Fertility Specialists 2Health News:Online Body Transformation Contest Proven to be a Life Changer 2Health News:Online Body Transformation Contest Proven to be a Life Changer 3Health News:Terminal cancer patients do not receive appropriate radiation therapy 2Health News:Khanna Institute of Vision and Your Health Connection Spring Expo 2Health News:Khanna Institute of Vision and Your Health Connection Spring Expo 3
(Date:1/15/2014)... , Jan. 15, 2014 Most osteoporosis patients ... to a recent online survey* sponsored by Mission Pharmacal ... the National Osteoporosis Foundation online support community, revealed that ... medication that comes in a form other than a ...
(Date:1/15/2014)... , Jan. 15, 2014  Celsion Corporation (the "Company") (NASDAQ: ... commitments from institutional investors to purchase an aggregate of ... an at-the-market registered direct offering, led by a dedicated ... definitive purchase agreements with these investors pursuant to which ...
(Date:1/15/2014)... 2014  Manufacturers, suppliers and distributors of innovative medical-related ... their most important business assets, intellectual property (IP). ... Because of the highly-competitive nature of the ... the most litigious industry sectors of cases involving ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3Intellectual Property Insurance for Medical-related Products and Services 2
... PRINCETON, N.J., Jan. 4, 2011 Pharmasset, Inc. (Nasdaq: ... 29th Annual J.P. Morgan Healthcare Conference to be held January ... CA. Schaefer Price, President and Chief Executive Officer, will provide ... at 9:00 AM (PT). To access a simultaneous ...
... Jan. 4, 2011 Boston Scientific Corporation (NYSE: ... M.D., Chief Medical Officer, Cardiac Rhythm Management, on an article ... the American Medical Association .  The article reported on a ... received an implantable cardioverter defibrillator (ICD) did not meet evidence-based ...
Cached Medicine Technology:Pharmasset to Present at the 29th Annual J.P. Morgan Healthcare Conference 2Pharmasset to Present at the 29th Annual J.P. Morgan Healthcare Conference 3Statement of Kenneth Stein, M.D., Chief Medical Officer, Cardiac Rhythm Management, Boston Scientific on JAMA Article 2
... provides fingertip ratchet disengagement allowing smooth, ratchet-free ... offers state-of-the-art quality in an instrument of ... durability. Low profile cutting tips allow access ... I instruments are available in just about ...
... The patented ratchet design provides fingertip ... ,The Series I Instrument program offers state-of-the-art ... profile, while maintaining strength and durability. Low ... in tight joint spaces. Series I instruments ...
... of procedurally specific tip configurations provide ... access to all areas of the ... Handled Graspers feature an infinite position ... without tearing or slipping even ...
Smith & Nephew ACUFEX scissors are constructed without pins for maximum strength, dependability, durability, and safety.,A wide range of tips and angles enable the surgeon to effectively dissect any ...
Medicine Products: