Navigation Links
Also in the March 24 JNCI
Date:3/24/2009

tence of risk reduction for up to 10 years after treatment in this trial reinforces the validity of the original trial findings and is consistent with an emerging new paradigm in cancer prevention, namely, that prevention may be achievable with short-term as opposed to life-long treatment," the authors write. Contact: NCI Press Office, ncipressofficers@mail.nih.gov, 301-496-6641


Overexpression of Fatty Acid Synthase Promotes Prostate Cancer in Mouse Models

Fatty acid synthase (FASN) can act as a prostate cancer oncogene in mouse models.

FASN, a key enzyme in the synthesis of long-chain fatty acids, is overexpressed in prostate cancer, relative to its expression in adjacent normal tissue. Additionally, previous studies showed that inhibition of FASN activity promoted programmed cell death in prostate cancer cell lines.

In the current study, Massimo Loda, M.D., of the Dana-Farber Cancer Institute in Boston, and colleagues overexpressed FASN in a variety of prostate cancer and precancerous cell lines.

Overexpression of FASN increased cell proliferation and substrate-independent growth. When immortalized prostate epithelial cells that expressed both FASN and the androgen receptor were injected into immunodeficient mice, the cells gave rise to invasive cancer. Inhibition of FASN gene expression led to programmed cell death in a prostate cancer cell line grown in culture. FASN expression showed an inverse correlation with the rate of programmed cell death in prostate cancer biopsy samples.

"The experimental evidence we provide on the oncogenic role of FASN in the prostate suggests that pharmacological targeting of FASN might represent an effective treatment for prostate cancer," the authors write.

Contact: Bill Schaller, william_schaller@dfci.harvard.edu, 617-632-5357'/>"/>

Contact: Caroline McNeil
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. JCI table of contents: March 23, 2009
2. Capitol Hill Briefing Scheduled for March 24 to Promote Colorectal Cancer Screening and Care
3. Herley Chairman Addresses Shareholders at Annual Meeting of Shareholders March 17, 2009
4. Hospice of Michigan Documentary to Air on Detroit Public Television Monday, March 23 and Sunday, March 29
5. NSC Hosts National Poison Prevention Week News Conference, Tuesday, March 17
6. Poison Prevention Week March 15 - 22
7. Optometry Career Conferences Set for Five N.C. Campuses in March
8. China Sky One Medical to Attend Two Conferences in March
9. Palatin Technologies to Present at Cowen Annual Health Care Conference on March 19, 2009
10. Dr. James F. Pingpank to Present at the Sixth International Symposium on Melanoma and Other Cutaneous Malignancies on March 13- 14, 2009 in New York City
11. China Pharma Holdings, Inc. to Host Fourth Quarter 2008 Earnings Conference Call at 8:30 a.m. EDT Wednesday March 18, 2009
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2014)... The report “Blepharitis – Pipeline Review, ... development for Blepharitis, complete with comparative analysis at ... of action (MoA), route of administration (RoA) and ... news and press releases. It also reviews key ... and special features on late-stage and discontinued projects. ...
(Date:11/27/2014)... Turks and Caicos Islands; BWI (PRWEB) November 28, 2014 ... for the Tuscany Resort in the Turks & Caicos. ... resorts by TripAdvisor in Providenciales, is announcing a few ... three bedroom villa rentals. And they are offering ... resort. , Additionally, The Tuscany, is having a ...
(Date:11/27/2014)... Absolute PhysioCare & Sports Rehab, a ... personalized treatment plans, highly skilled and educated therapists ... sports injuries reach pre-injury state. Whether it is ... Absolute Physio has the right treatment for it. ... meniscal injuries, groin strain and sports hernia can ...
(Date:11/27/2014)... 27, 2014 Cambrionix Ltd today announced that ... 50, a ranking of the 50 fastest-growing technology companies in ... over the last five years. Cambrionix Ltd grew 2989 ... first in the region of Cambridgeshire and East and first ... Says:, “This award is recognition of the hard work put ...
(Date:11/27/2014)... 2014 An inventor from Buffalo, N.Y., ... of life, and she wants to lessen its impact. ... I decided that there needed to be a way ... Easy to use and producible in design variations, the ... private areas throughout the day. It avoids bad odors, ...
Breaking Medicine News(10 mins):Health News:Blepharitis Pipeline Market Review on Drugs and Companies H2 2014 2Health News:Blepharitis Pipeline Market Review on Drugs and Companies H2 2014 3Health News:Blepharitis Pipeline Market Review on Drugs and Companies H2 2014 4Health News:The Tuscany on Grace Bay, Top-Rated TripAdvisor Resort in the Turks & Caicos Islands, Offers Special Pre-Christmas & January 2015 Promotions! 2Health News:Coquitlam Physiotherapy Clinic Now Helps Clients Reach Pre-Injury State 2Health News:Cambrionix Ltd Ranks Top 10 in the Deloitte UK Technology Fast 50 2Health News:Cambrionix Ltd Ranks Top 10 in the Deloitte UK Technology Fast 50 3Health News:Cambrionix Ltd Ranks Top 10 in the Deloitte UK Technology Fast 50 4
... Producer ... ... announces the April 13, 2010 release of , in my room , -a multi ... produced by LML recording artist D.C. Anderson , the prolific writer/producer/performer behind the successful ...
... ... ... Human Thriving Foundation is a nonprofit organization whose Mission Statement is: To scientifically increase ... Behavioral Laboratory announces today that it appears that they have Cracked the DNA Code ...
... ... monitoring using mobile networks will rise to almost $1.9 billion globally by 2014, with heart ... , ... 2010 -- According to Juniper Research, revenues from remote patient monitoring using mobile networks will ...
... ... used in MTV’s ‘Jersey Shore’ was a Bullfrog Spa. , ... Salt Lake City, Utah (Vocus) April 13, 2010 -- Ever ... been understandably reluctant to point it out, Bullfrog International is ready to admit that it ...
... ... Muscle Pain Relief. , ... (Vocus) April 13, 2010 -- Susan Z. Robins, President of ... in January 2010. The response was overwhelmingly positive and Muscle Angel Massagers™ were ...
... ... range of Intacs to benefit patients suffering from keratoconus , ... (Vocus) April 12, 2010 -- Khanna Institute will now be ... the announcement by the maker of Intacs corneal implants Addition Technology, Inc., that it has ...
Cached Medicine News:Health News:Peter Bradley Adams, Victoria Shaw, Many Distinguished Colleagues Ally To Benefit National MS Society With CD Release: In My Room 2Health News:Peter Bradley Adams, Victoria Shaw, Many Distinguished Colleagues Ally To Benefit National MS Society With CD Release: In My Room 3Health News:Peter Bradley Adams, Victoria Shaw, Many Distinguished Colleagues Ally To Benefit National MS Society With CD Release: In My Room 4Health News:Behavioral Laboratory Cracks the DNA Code of Happiness 2Health News:Revenues from Mobile Health Monitoring to Reach $1.9 Billion Globally by 2014 Says Juniper Research 2Health News:Revenues from Mobile Health Monitoring to Reach $1.9 Billion Globally by 2014 Says Juniper Research 3Health News:The Identity of the Jersey Shore Hot Tub Revealed 2Health News:Muscle Angel Massagers™ Receive Accolades from Dentists and Hygienists 2Health News:Muscle Angel Massagers™ Receive Accolades from Dentists and Hygienists 3Health News:Muscle Angel Massagers™ Receive Accolades from Dentists and Hygienists 4Health News:Muscle Angel Massagers™ Receive Accolades from Dentists and Hygienists 5Health News:Khanna Institute to Offer Newly FDA Approved Expanded Range of Intacs for Keratoconus 2Health News:Khanna Institute to Offer Newly FDA Approved Expanded Range of Intacs for Keratoconus 3
(Date:11/26/2014)... SAN JOSE, Calif. , Nov. 26, 2014 ... proprietary technologies to produce novel therapies for infectious ... Opal , M.D., an internationally recognized key opinion ... to the Company,s scientific advisory board. ... , Ph.D., stated, "We believe Dr. Opal,s extensive ...
(Date:11/26/2014)... CHARLOTTE, N.C. , Nov. 25, 2014  At ... San Antonio this October, KaVo Kerr Group ... Institute Technology Expo, offering attendees the opportunity to see ... to well-respected key opinion leaders deliver lectures on the ... Kerr Group products include the new DEXIS CariVu Caries ...
(Date:11/26/2014)... Calif. , Nov. 25, 2014 /PRNewswire/ ... company focused on the development of mobile ... accurate testing in hospital and pre-hospital settings, ... Organization (ISO) 13485:2003 certification.  The certification was ... one of the world,s leading certification bodies. ...
Breaking Medicine Technology:Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 3KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 2KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 3Nanomix Receives ISO 13485:2003 Certification 2
... Neurologix, Inc. (OTC Bulletin Board: NRGX ... landmark, randomized, double-blind Phase 2 clinical trial of NLX-P101, ... were presented during a symposium at the 2nd World ... trial, Dr. Peter Lewitt, Director of the Parkinson,s Disease ...
... Oct. 1 Elekta recently launched ABAS ( ... Simultaneous Truth and Performance Level Estimation (STAPLE) algorithm ... standard for autosegmentation accuracy—deforms atlases of anatomy previously ... patient image, creating a new structure set fit ...
Cached Medicine Technology:New Details Presented at the World Parkinson Congress on Neurologix's Successful Phase 2 Trial of Gene Therapy for Parkinson's Disease 2New Details Presented at the World Parkinson Congress on Neurologix's Successful Phase 2 Trial of Gene Therapy for Parkinson's Disease 3New Details Presented at the World Parkinson Congress on Neurologix's Successful Phase 2 Trial of Gene Therapy for Parkinson's Disease 4New Details Presented at the World Parkinson Congress on Neurologix's Successful Phase 2 Trial of Gene Therapy for Parkinson's Disease 5New Details Presented at the World Parkinson Congress on Neurologix's Successful Phase 2 Trial of Gene Therapy for Parkinson's Disease 6New Details Presented at the World Parkinson Congress on Neurologix's Successful Phase 2 Trial of Gene Therapy for Parkinson's Disease 7Elekta Launches ABAS 2.0 Autosegmentation Software Used to Plan Radiation Therapy in Patients With Cancer 2
Zone Quick is a simple and accurate system that measures tear volume in just 15 seconds per eye. Each box has an easy to read diagnostic indicator rule....
... been introduced by FCI Ophthalmics, Inc. Designed by ... addressed the limitations previously encountered with balloon catheter ... in to position through the nose, it has ... need to pass the very large diameter end ...
... the heart of the Diagnosys electrophysiology system is ... allowing it to support a wide variety of ... , Clinical Function Testing ,The Espion ... easily perform all the current standard clinical visual ...
... are not restricted to small central ... These are full field capable, all ... perimeters you'll ever need to ensure ... They also include the most ...
Medicine Products: