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Also in the July 8 JNCI
Date:7/8/2008

y disenrollment during the two years after diagnosis with enrollment changes by matched control subjects who did not have a cancer diagnosis.

Cancer patients were statistically significantly less likely to disenroll from a Medicare managed care plan than individuals who were cancer-free. The results were consistent across age, disease site and stage, race, and location in the United States.

"If voluntary disenrollment from Medicare managed care is, in fact, beneficiaries' way of 'voting with their feet,' then our results suggest that enrollees facing a serious, potentially life-threatening illness are as satisfied with Medicare managed care, if not more so, than their cancer-free peers," the authors write.

Contact: Jeanne D'Agostino, dagostij@mskcc.org, (646) 227-3573

Cyclin A1 Expression Promotes Prostate Cancer Invasion and Metastases

Cyclin A1 promotes prostate cancer invasion and metastasis by increasing the expression of key signaling proteins and extracellular proteins.

Cyclin A1 is a cell cycle regulatory protein and is thought to play a role in a variety of cancers. Recently, Jenny Liao Persson, Ph.D., of the Lund University Hospital in Malm, Sweden, and colleagues found that it was highly expressed in prostate tumor samples and was associated with aggressive tumor histology and expression of vascular endothelial growth factor (VEGF), one of the key factors in angiogenesis.

In the current study, Persson's team examined expression of cyclin A1, VEGF, metalloproteinases (MMPs) in primary malignant tumors, and adjacent benign prostatic tissues from 482 patients with prostate cancers of various stages. The team further tested the impact of increased cyclin A1 expression in tumor invasion and metastasis in a mouse model of prostate cancer.

The researchers found that prostate cancer cells engineered to overexpress cyclin A1 caused
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Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

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