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Also in the July 29 JNCI
Date:7/29/2008

Treatment with a potentially cardiotoxic drug may often be inevitable to extend survival for a cancer patient. However, it is essential to be aware of the risk of cardiotoxicity, not only because cardiotoxicity can progress to a potentially fatal outcome if not treated but also because it lowers the quality of patient life," the authors write.

In an accompanying editorial, Dawn Hershman, M.D., and Alfred I. Neugut, M.D., Ph.D., of Columbia University Medical Center in New York write that it has been difficult to predict which patients are most likely to develop cardiotoxicity following anthracycline therapy. Neither randomized clinical trials nor studies that rely on large administrative databases are adequate for addressing the issue. Therefore, Ryberg's study is an important step to helping physicians personalize cancer care for their patients.

"If we can better predict who is at greatest risk for toxicity and who is not, we may be able to comfortably offer standard treatment to a larger percentage of the population," the editorialists write.

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Lapatinib Reduces Brain Metastases in Mouse Model of Metastatic Breast Cancer

Lapatinib reduces the number of large brain metastases in a mouse model of metastatic breast cancer, relative to untreated mice.

Symptomatic brain metastases affect between 10 and 20 percent of women with metastatic breast cancer, and the problem is particularly common for women whose tumors overexpress the HER2 protein. However, trastuzumab, an antibody that blocks the HER2 protein activity and is the standard of care for HER2-posi
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Contact: Liz Savage
elizabeth.savage@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2 3 4 5

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