Navigation Links
Also in the July 29 JNCI
Date:7/29/2008

The Same Dose of Anthracycline Is Not Safe for Everyone

Not all patients can tolerate the currently recommended cumulative dose of epirubicin. New models can help physicians calculate the epirubicin dose associated with a 5 percent risk of cardiotoxicity for individual patients.

Oncologists frequently use anthracyclines, including epirubicin and doxorubicin, to treat breast cancer patients. However, the drugs cause lasting heart problems in a substantial number of patients. To limit the problem, current treatment guidelines suggest that patients receive no more than 900 mg/m2 epirubicin over the course of their cancer care.

In the current study, Marianne Ryberg, M.D., of the University of Copenhagen and colleagues followed 1,097 patients with metastatic breast cancer who were treated in a single hospital near Copenhagen between 1983 and 2003. The researchers assessed patients' risk factors for cardiotoxicity and corrected for the risk of death from all other competing causes of death, including cancer. (The studies that have previously concluded that the upper safe limit of epirubicin is 900 mg/m2 have not generally corrected for other causes of death.) Using these data, they calculated the maximum cumulative dose of epirubicin that is associated with a 5 percent risk of developing heart disease.

Ryberg and colleagues found that patient age, predisposition to heart disease, previous chest irradiation, and prior hormonal cancer therapy were associated with an individual's risk of developing heart problems following epirubicin treatment. By contrast, the researchers found that treatment with less epirubicin, a higher tumor burden, prior chemotherapy, and older age of the patient were associated with an increased risk of death from other, non-cardiac, causes.

Based on these data, the researchers lowered the cumulative dose recommended for most patients, with maximum doses ranging from 300 mg/m2 to 900 mg/m2. "
'/>"/>

Contact: Liz Savage
elizabeth.savage@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2 3 4 5

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... ... 2015 , ... The PT Outcomes Registry is an organized system for collecting ... The Registry is being developed by the American Physical Therapy Association (APTA). , Al ... selected to contribute FOTO Outcomes measures as one of the primary global outcomes measures ...
(Date:8/31/2015)... ... August 31, 2015 , ... Cosmetic Town Journal is ... need to have a successful cosmetic procedure; from publishing encyclopedic medical articles to ... is always ready to help. , It is clear that the Cosmetic Town ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... When it comes to undergoing a hair ... top of the head. Adding more volume to the hair on top of the ... patients who have a good amount of donor hair on other areas of their head. ...
(Date:8/31/2015)... ... 2015 , ... The Lisle family law firm of Momkus McCluskey, LLC ... his peers to earn a “Leading Lawyers” distinction. , The “Leading ... of Illinois. The nomination process is based on statewide peer survey nominations and the ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... ... as Vice President, Marketing and Corporate Communications. In this capacity, Michael will provide ... CareSource is an industry leader in consumer-focused programs that have contributed to the ...
Breaking Medicine News(10 mins):Health News:FOTO Selected as Official Registry Partner with Physical Therapy Outcomes Registry 2Health News:Cosmetic Town: A One Stop Plastic Surgery Community 2Health News:Body Hair Transplants to Help Achieve a Full Head of Hair 2Health News:DuPage County Family Law Attorney Named Illinois Leading Lawyer 2Health News:CareSource Names Vice President, Marketing and Corporate Communications 2
... levels of exhaled nitric oxide in adolescents with asthma and ... disease. , The study was conducted by the Inner ... Institute of Allergy and Infectious Diseases (NIAID), part of the ... The Lancet reports the ICAC findings. , Approximately ...
... 19 Western Australians will be,the first in the ... that,has been shown to improve a person,s ability to ... health initiative will be launched by Australia,s Aged Care,Commissioner ... the,Duxton Hotel on September 19th as part of Dementia ...
... in Non-Invasive Aesthetic Treatments , ... ... http://www.americanlaser.com [American Laser Centers __title__ American Laser], the ... services in the U.S., has announced Kymberly Botelho, the host ...
... a top concern for businesses of all sizes. Just when,employers ... these that complicate the enrollment:, -- Employees don,t ... of what their employer provides. -- Health ... -- A handful of employees who are located in remote ...
... NEW BRUNSWICK, N.J., Sept. 18 Fans ... game this Sunday, September 21, will be,encouraged ... fight: supporting PSE&G Children,s,Specialized Hospital, an inpatient ... premature birth, and life-changing,conditions., (Photo: ...
... Tenn., Sept. 18 Radiation Oncology Services,of America, ... America,Inc., announced today the inaugural meeting of its ... 2008. The Scientific Advisory Board,is comprised of a ... field.,It will advise ROSA on numerous scientific and ...
Cached Medicine News:Health News:Monitoring exhaled nitric oxide does not help manage asthma 2Health News:Monitoring exhaled nitric oxide does not help manage asthma 3Health News:New Brain Fitness Program to Fight Memory Loss 2Health News:New Brain Fitness Program to Fight Memory Loss 3Health News:Popular Denver Divas Host to Manage the New American Laser Centers Clinic in Arvada 2Health News:New Web-Based Enrollment System Gives Employers Flexibility and Control in Managing Benefits Enrollments 2Health News:New Web-Based Enrollment System Gives Employers Flexibility and Control in Managing Benefits Enrollments 3Health News:PSE&G Children's Specialized Hospital and New York Giants Team Up to Enable Donations to Hospital Through Texting 2Health News:Radiation Oncology Services of America, Inc. Announces Formation of Scientific Advisory Board 2
(Date:8/31/2015)... , Aug. 31, 2015  Soligenix, Inc. ... biopharmaceutical company developing products that address unmet medical ... biodefense, announced today it has completed enrollment of ... Review Committee (DRC) earlier this year, into the ... a first-in-class innate defense regulator (IDR) and is ...
(Date:8/31/2015)... Aug. 31, 2015  QT Vascular Ltd., together with its ... with its subsidiaries, the "Group"), a global company ... advanced therapeutic solutions for the minimally invasive treatment ... of the below-the-knee ("BTK") cohort of patients in ... presented on August 15, 2015 at the 5th ...
(Date:8/30/2015)... y LONDRES, August 30, 2015 ... holística de l cuidado al paciente ... trayecto   Royal Philips  ... europeo de IntelliSpace Cardiovascular , un sistema web ... herramientas para acceder, analizar y compartir imágenes cardiovasculares e ...
Breaking Medicine Technology:Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 2Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 3Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 4Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 5Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 6Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 2Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 3Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 4Philips presenta IntelliSpace Cardiovascular en el Congreso ESC 2015 2Philips presenta IntelliSpace Cardiovascular en el Congreso ESC 2015 3
... Caliper Life Sciences, Inc. (Nasdaq: ... and services for drug discovery and life sciences ... Austria AG for the co-development and manufacture of ... The agreement combines Sony DADC,s premier Blu-ray Disc™ ...
... Nov. 3, 2010 Cyberonics, Inc. (Nasdaq: CYBX ) ... second quarter ended October 29, 2010 of its fiscal year ending ... ET.  The company will conduct a conference call to discuss those ... Fiscal Year 2011 Second Quarter Results Conference Call InstructionsTo ...
Cached Medicine Technology:Caliper Life Sciences and Sony DADC Collaborate to Develop Plastic Microfluidic Solutions 2Cyberonics Announces Conference Call to Discuss Fiscal Year 2011 Second Quarter Financial Results 2
Hemagglutination slide test for the qualitative and quantitative detection of Rheumatoid Factor in serum or synovial fluid....
Hemagglutination slide test for the differential qualitative detection and quantitative determination of infectious mononucleosis and other heterophile antibodies in serum or plasma....
Color-enhanced hemagglutination slide test for the rapid qualitative and semi-quantitative detection of infectious mononucleosis heterophile antibodies in serum or plasma....
... Inverness Medical Professional Diagnostics is a leading ... IFA and DFA test menu that includes ... STDs as well as miscellaneous conjugates and ... you a wide assortment of substrates and ...
Medicine Products: