Navigation Links
Also in the Jan. 27 JNCI
Date:1/27/2009

Germ-line Mutation Associated with Multi-Nodular Goiter and Papillary Thyroid Cancer

A germ-line mutation in the gene that encodes thyroid transcription factor-1 (TTF-1) may be associated with multi-nodular goiter (MNG) and with progression to papillary thyroid cancer (PTC).

It is known that some patients who have MNG progress to PTC, but a genetic link between the two diseases was not known. TTF-1 is known to be involved in thyroid development and is expressed at a lower level in malignant thyroid tissue than normal tissue.

In the current study, Elly S. W. Ngan, Ph.D., of the University of Hong Kong, and colleagues examined the gene that encodes TTF-1, called TITF-1/NKX2.1, in three groups of people: 20 individuals with MNG that progressed to PTC; 284 PTC patients with no history of MNG; and 349 healthy individuals.

Four of the 20 MNG/PTC patients carried a single point mutation in the TITF-1/NKX2.1 gene, including two individuals with a family history of MNG. Introduction of the mutant gene into cells grown in vitro increased their proliferation rate and increased expression of genes associated with cancer cell growth.

"Our findings may be relevant to the search for molecular markers to assess risk for MNG/PTC, through regular screening of relatives of PTC patients affected with MNG," the authors conclude.

Contact: Winnie Lam, pylamw@hkucc.hku.hk, + 852-2809-5102

Early Mammograms May Have Net Harm in Some BRCA Mutation Carriers

The risk of radiation-induced breast cancer may outweigh the benefits of mammography in women under the age of 30 who carry a mutation in BRCA1 or BRCA2, according to a mathematical modeling study.

The general recommendation for women who carry a mutation in BRCA1/2 is to start getting annual mammograms as early as 25 to 30 years of age. However, it is not clear whether the risk of ra
'/>"/>

Contact: Caroline McNeil
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2 3 4

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The City of West Hollywood hosted a news conference on ... anniversary of the Supreme Court decision Roe v. Wade, which legalized ... the Roe vs. Wade decision and the fight to protect a ... City of West Hollywood Councilmember Abbe Land. “We need to continue ...
(Date:1/22/2015)... VogueQueen is a seasoned and trusted leader who consistently ... thrilled to have it lead the wedding dress industry into ... prom dresses for the global market. , “The CEO of ... he focuses on continuing the goal of operational excellence and ...
(Date:1/22/2015)... 2015 AngelWeddingDress, the premier women’s dress ... wedding dresses. View website of AngelWeddingDress.com to ... maternity wedding dresses online for a bridal party. AngelWeddingDress ... quality for them. Its maternity wedding dresses are specially ...
(Date:1/22/2015)... January 22, 2015 Thousand of GranuFlo ... Care recalled its GranuFlo and NaturaLyte dialysis concentrates continue ... in U.S. District Court, District of Massachusetts, Bernstein Liebhard ... the Court has remanded a case filed by the ...
(Date:1/22/2015)... Plainsboro, NJ (PRWEB) January 22, 2015 ... advocate and keynote speaker at the upcoming 32nd ... by ACCME-accredited Physicians’ Education Resource®, LLC (PER®) , ... breast would have gone undetected if she had not ...
Breaking Medicine News(10 mins):Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6
... the gold standard for most patients with left main coronary ... disease and one that affects thousands. ... lower-risk patients with this condition who underwent angioplasty with medication-coated ... minimally invasive procedure than surgery, angioplasty is performed by snaking ...
... (HealthDay News) -- A poor "gut sense" of numbers may be ... Researchers had 71 ninth graders enrolled in a 10-year study ... numbers, such as asking them to guess how many dots were ... Researchers also divided the students into four groups: those shown to ...
... a nurse,s decision to stay at or leave a ... from Rice University, the University of Pittsburgh and Baylor ... nursing assistants, researchers found that attitudinal factors such as ... turnover in long-term care facilities. While previous studies ...
... dish soap into a sink full of greasy water. What happens? ... retreats to the edges of the sink. Now, what if ... cancer-promoting proteins and the dish soap was a potential drug? According ... drug could force the proteins to the cell,s membrane (a.k.a., the ...
... Cancer Center, offers hope for people with a rare disorder ... excessive production of red blood cells. Symptoms include an ... in some cases the disease is a precursor to acute ... with a mutation in the JAK2 gene, a small number ...
... study determined that percutaneous coronary intervention (PCI) was safe ... were referred for liver transplantation. Larger studies are needed ... end-stage liver disease (ESLD). Details of the study are ... published by Wiley-Blackwell on behalf of the American ...
Cached Medicine News:Health News:Angioplasty with stents may be safe in long-term for low-risk heart patients 2Health News:Angioplasty with stents may be safe in long-term for low-risk heart patients 3Health News:Math Learning Disabilities Linked to Poor 'Gut Sense' of Numbers 2Health News:It's not about the money for long-term care nurses 2Health News:Molecular glue sticks it to cancer 2Health News:Angioplasty may be feasible for liver transplantation candidates with heart disease 2
(Date:1/23/2015)... and BOSTON , January 23, 2015 ... discovery and development company, is delighted to announce that the ... awarded to Miles Congreve (Vice President of Chemistry), ... Malcolm Weir (Chief Executive Officer and co-founder) for ...
(Date:1/22/2015)... Colo. , Jan. 22, 2015  BiOptix is pleased ... as Vice President of Chemistry and Biochemistry. Scott joins ... Pharmaceuticals, AstraZeneca Pharmaceuticals, and Amgen throughout the course of ... development. "Scott is a nationally recognized thought ...
(Date:1/22/2015)... WOODBRIDGE, ON , Jan. 22, 2015 /PRNewswire/ - Pivotal Therapeutics ... company with a focus on Omega-3 therapies for cardiovascular disease ... summary of the Company,s accomplishments in 2014 and its outlook ... Dear Fellow Shareholders, We would like ...
Breaking Medicine Technology:Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7
... in Carotid Atherosclerosis, LEXINGTON, Mass., Oct. 24 ... its pivotal clinical trial (PROVIDENCE-1),studying the effect of ... peripheral arterial disease (PAD) will be,presented on November ... late breaker,Scientific Session at the American Heart Association,s ...
... Today the National Legal and Policy,Center (NLPC) asked ... for,International Development (USAID) to investigate the possibility that ... groups operating,needle exchange programs for drug users in ... activist George,Soros are recipients of these legally questionable ...
Cached Medicine Technology:ActivBiotics to Present Results of Pivotal Study in the Treatment of Peripheral Arterial Disease at AHA Meeting 2ActivBiotics to Present Results of Pivotal Study in the Treatment of Peripheral Arterial Disease at AHA Meeting 3Ethics Group Asks USAID Inspector General to Investigate Legality of Grants to Soros Groups 2
... The Vasotrax is an ... pressure and heart rate non-invasively, ... fact, significantly more accurate than ... On a full battery charge, ...
... (IGF-II) is a 7.5 kDa peptide which is ... to have mitogenic and metabolic actions involved in ... by binding to target cell receptors. IGF-II binds ... receptor, a monomeric protein which also serves as ...
... Leptin is a proteohormone with a molecular weight ... by the ob gene and produced by adipocytes [1,2]. ... in the regulation of body weight [1-3]. In ... in both men and women [4]. A relationship ...
... is synthesized by the parathyroid glands ... decreased extracellular calcium concentrations. PTH prevents ... decreasing calcium excretion by the kidney. ... PTH is rapidly degraded into 4 ...
Medicine Products: