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Also in the April 7 JNCI
Date:4/7/2009

ells promotes tumor growth in mouse models.

TGF- is a cytokine that promotes cell proliferation in a variety of tissues and its expression has been associated with progression of diffuse-type gastric cancer. The role of TGF- in gastric cancer is controversial, however.

In the current study, Kohei Miyazono, M.D., of the University of Tokyo and colleagues disrupted TGF- signaling by introducing a dominant-negative TGF- receptor into gastric cancer cell lines. They then investigated proliferation of these cells in culture and tumor growth and angiogenesis in mice injected with these cells.

Expression of the dominant-negative receptor did not increase cancer cell proliferation in vitro but increased tumor growth when the cells were injected into mice. Treatment of tumor-bearing mice with antiangiogenesis compounds slowed tumor growth, suggesting that TGF- signaling accelerated tumor growth by stimulating blood vessel development.

"In conclusion, we have shown that disruption of TGF- signaling in a mouse model of diffuse-type gastric carcinoma, which may be analogous to what occurs during progression of this disease in humans, promotes tumorigenesis by accelerating angiogenesis," the authors write. Based on these data, they hypothesize that angiogenesis inhibitors may be useful treatments for those cancers with disrupted TGF- signaling pathways. Contact Kohei Miyazono, email: miyazonok1@mac.com or miyazono-ind@umin.ac.jp, +03-5841-3345


Perfluorinated Chemicals Not Associated with Cancer in General Population

Perfluorooctanoate and perfluorooctanesulfonate plasma concentrations are not associated with the risk of prostate, bladder, pancreatic, or liver cancer.

The two chemicals, commonly used in manufacturing, are widely found in the environment. Pre
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Contact: Caroline McNeil
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1 2 3 4

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