Navigation Links
AlphaRx Reports Positive Preclinical Data on GAI-122 Against Liver Disease
Date:7/8/2009

    GAI-122, an investigational injectable nano-emulsion formulated with
    AlphaRx's proprietary drug delivery technology, provides significant
    hepatoprotection in multiple animal models of acute hepatitis suggesting
    that GAI-122 may reduce necro-inflammation and may halt disease
    progression to fibrosis or cirrhosis.

MARKHAM, ON, July 8 /PRNewswire-FirstCall/ - AlphaRx Inc. (OTCBB: ALRX) today reported positive preclinical results on GAI-122 injectable nano-emulsion in multiple models of acute hepatitis, an inflammatory liver disease.

GAI-122 significantly reduced Aminotransferase (ALT), an enzyme released into the blood that indicates damage to the liver, following IP administration in three different preclinical models of acute liver injury. Very high levels of ALT are usually due to acute hepatitis or a viral infection.

In the a-Fas model of liver injury, GAI-122 markedly reduced ALT levels by 90% from baseline, where control ALT values were ~22,000 IU/L. Significant efficacy was also demonstrated in the rat TNFa/Gln model and in the Drug-induced liver injury (DILI) model.

"DILI accounts for more than 50% of acute liver failure and there are no satisfactory treatment options currently available. The excellent efficacy data demonstrated by these studies suggest that GAI-122 may represent a potential first line treatment option for patients with liver disease", stated Dr. Michael Weisspapir, MD, PhD, Chief Medical Scientist of AlphaRx.

In October 2008, AlphaRx licensed GAI-122 to Gaia BioPharma. Under the terms of the amended agreement, AlphaRx is eligible to receive milestone payments of up to $50 million for the successful development and commercialization of GAI-122, as well as royalties on worldwide sales. In addition, Gaia BioPharma has assumed all development costs.

About AlphaRx Inc.

AlphaRx is a specialty pharmaceutical company dedicated to developing proven therapies by reformulating FDA approved and marketed drugs which through the application of its proprietary site-specific nano drug delivery technology, offers improved medical benefits and a potential for significant commercial product development.

About Gaia BioPharma

Gaia BioPharma Limited, a privately held, early stage biopharmaceutical company focused on hospital-based injectable therapeutics. Gaia BioPharma seeks to address key unmet therapeutic needs by taking established compounds and changing their administration routes to create patent-protected, value-added products.

FORWARD LOOKING STATEMENTS:

This release contains forward-looking statements within the meaning and pursuant to the Safe Harbor provisions of the Securities Litigation Reform Act of 1995 and involve risks and uncertainties that may individually or mutually impact the matters herein described, including but not limited to product development and acceptance, manufacturing, competition, regulatory and/or other factors, which are outside the control of the Company.


'/>"/>
SOURCE AlphaRx Inc.
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. AlphaRx and Gaia BioPharma Report Positive Efficacy Results in a Pre-Clinical Trial of GAI-122 Injectable Nano-emulsion for Post-operative Delirium
2. AlphaRx Shareholder Update
3. AlphaRx and Gaia BioPharma Provide GAI-122 Development Update
4. AlphaRx Signs Cooperative Research and Development Agreement with US Army
5. AlphaRx Provides Corporate and Development Update
6. AlphaRxs Indaflex(TM) Continues its Clinical Development
7. AlphaRx CEO Accumulates More Company Shares
8. AlphaRx Officers and Directors To Exercise Options, Warrants and Retain Shares
9. AlphaRx Announces Debt Conversion
10. AlphaRx To Present at 47th Annual ICAAC
11. Recent News Reports of Sweetener Reformulations Raise Questions About Motivations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2017)... PA (PRWEB) , ... July 26, 2017 , ... An ... a hospital, and I haven’t yet seen an effective and dignified way to keep ... idea for the LEECH CUP." , This invention provides an effective way to keep ...
(Date:7/26/2017)... ... July 26, 2017 , ... ... as part of their continued efforts to provide innovative offerings to their healthcare ... IT resources and build dynamic, high-performing teams to address healthcare IT’s biggest challenges. ...
(Date:7/26/2017)... ... July 26, 2017 , ... ... will host its 2017 Process Validation and Process Validation Statistics Conferences in ... to process validation lifecycle challenges faced by process validation professionals and statisticians ...
(Date:7/26/2017)... (PRWEB) , ... July 26, 2017 , ... “We are ... offer the ability for patients to schedule an appointment online in real time,” said ... the Six Month Smiles provider directory will bring more Six Month Smiles patients to ...
(Date:7/26/2017)... ... , ... The Amnesty Rally 2017 will be held on Saturday, July 29 ... Drive in Monroe (adjacent to the Louisiana Purchase Gardens & Zoo). , The ... Monroe. Citizens can turn in unregistered, illegally-held and imitation guns to law enforcement officers ...
Breaking Medicine News(10 mins):
(Date:7/26/2017)... 2017 Sancilio Pharmaceuticals Company, Inc. (SPCI) today ... evaluating Altemia TM , an oral therapy for pediatric ... Disease (SCD). The SCOT Trial, is a double-blind, placebo-controlled, ... of Altemia TM in pediatric patients aged 5-17 ... 125274. "The completion ...
(Date:7/24/2017)... Mich. , July 24, 2017  Diplomat Pharmacy, ... it will release its second quarter 2017 operating results ... a conference call to follow at 5:00 p.m. ET. ... participants may listen to a live broadcast of the ... callers, and referencing participant code 51641230 approximately 15 minutes ...
(Date:7/20/2017)... , July 20, 2017  Prime Therapeutics LLC (Prime) released ... , M.D., following today,s Institute for Clinical and Economic Review,s ... on the effectiveness and value of abuse-deterrent formulations (ADF) of ... policy roundtable at the meeting. ... material cost benefit to the use of abuse-deterrent formulations (ADF) ...
Breaking Medicine Technology: