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Allos Therapeutics Reports Third Quarter 2007 Financial Results
Date:11/5/2007

in patients with lymphoma and non-small cell lung cancer (NSCLC).

PROPEL

In September 2007, the Company announced the completion of pre-planned interim analyses of patient response and safety data from the Company's pivotal Phase 2 PROPEL trial of PDX in patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). Results of the interim analysis of patient response data exceeded the pre-specified threshold for continuation of the trial, which required a minimum of four responses (complete or partial) out of the first 35 evaluable patients, as determined by independent oncology review. In addition, an independent Data Monitoring Committee (DMC) completed an interim analysis of the safety data from the first 35 evaluable patients and recommended that the trial continue per the protocol. In accordance with the trial protocol, the DMC will conduct another interim analysis of safety data from the first 65 evaluable patients. The Company expects to report the outcome of the 65-patient safety analysis by the end of 2007 and complete enrollment in the trial in the second quarter of 2008.

PDX in CTCL

In August 2007, the Company announced the initiation of patient enrollment in a Phase 1, open-label, multi-center study of PDX with vitamin B12 and folic acid supplementation in patients with relapsed or refractory cutaneous T-cell lymphoma (CTCL). Up to 56 evaluable patients will be enrolled in the study with the objective of determining the optimal dose and safety profile of PDX in this population. A total of 20 of these patients will be enrolled at the determined optimal dose and schedule.

PDX in NSCLC (Phase 1)

In October 2007, data from the Company's Phase 1 dose ranging study of PDX with vitamin B12 and folic acid supplementation in patients with previously treated advanced NSCLC were presented at the 2007 AACR-NCI-EORTC conference. In this study, a total of 22 patients with relapsed or refractory NSCLC were treated at doses
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SOURCE Allos Therapeutics, Inc.
Copyright©2007 PR Newswire.
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