Navigation Links
Allergic disease worsens respiratory symptoms and exacerbations in COPD

Patients with chronic obstructive pulmonary disease (COPD) who also have allergic disease have higher levels of respiratory symptoms and are at higher risk for COPD exacerbations, according to a new study from researchers at Johns Hopkins University in Baltimore.

"Although allergic sensitization and allergen exposure are known to be associated with impairments in lung function, the effects of allergic disease on respiratory symptoms in COPD patients has only recently been studied," said researcher Nadia N. Hansel, MD, MPH, associate professor of medicine at the Johns Hopkins Asthma & Allergy Center. "Accordingly, we examined the effects of allergic disease on respiratory health in two sets of patients with COPD, one a nationally representative sample of 1,381 COPD patients from the National Health and Nutrition Survey III (NHANES III) and the other a cohort of 77 former smokers with COPD from a study of the effects of endotoxin exposure on health status."

"We found that COPD patients with an allergic phenotype had an increased risk of lower respiratory symptoms and respiratory exacerbations."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

In the NHANES III cohort, 296 COPD patients had an allergic phenotype, which was defined as self-reported doctor-diagnosed hay fever or allergic upper respiratory symptoms. These patients were significantly more likely to wheeze, have chronic cough, and have chronic phlegm and had a significantly increased risk of experiencing a COPD exacerbation that required an acute visit to the doctor.

In the second cohort of 77 COPD patients, the 23 patients with allergic sensitization (determined by immunoglobulin E testing) were significantly more likely to wheeze, to experience nighttime awakening due to cough, and to have COPD exacerbations requiring antibiotic treatment or an acute visit to the doctor.

"Our findings in two independent populations that allergic disease is associated with greater severity of COPD suggest that treatment of active allergic disease or avoidance of allergy triggers may help improve respiratory symptoms in these patients, although causality could not be determined in our cross-sectional study," said Dr. Hansel.

There were a few limitations to the study, including possible misclassification of COPD in some NHANES patients and the use of self-reported respiratory symptoms and COPD exacerbations.

"Current COPD guidelines do not address the management of allergic disease in COPD patients," Dr, Hansel said. "Additional studies of the relationship between allergic disease and COPD are clearly needed."


Contact: Nathaniel Dunford
American Thoracic Society

Related medicine news :

1. Study identifies causes for high rates of allergic reactions in children with food allergies
2. Multi-functional anti-inflammatory/anti-allergic developed by Hebrew University researcher
3. Immunotherapy reduces allergic patients sensitivity to peanuts
4. Many Allergic to Fire Ants Sting Dont Get Preventive Shots
5. Children with milk allergy may be allergic to school
6. Witnessing, Experiencing Traumatic Events May Worsen Heart Disease
7. Pulse pressure elevation could presage cerebrovascular disease in Alzheimers patients
8. Mayo Clinic offers newly approved treatment for acid reflux disease
9. Spouses of Cancer Patients May Have Raised Risk of Heart Disease, Stroke
10. Huntingtons Disease Linked to Reduced Cancer Risk in Study
11. AstraZeneca and DNDi to collaborate on drug screening for neglected tropical diseases
Post Your Comments:
(Date:11/24/2015)... ... , ... In response to recent news highlighting Oxycodone fraud, Novus Medical Detox ... United States grew 400 percent between 1999 and 2010, far more than the combined ... of all fatal drug overdoses. (1) , While oxycodone and the extended release form ...
(Date:11/24/2015)... AL (PRWEB) , ... November 24, 2015 , ... American ... announced today the opening of a holiday pop-up clinic located in Metro Atlanta’s North ... needs in a new and different way. The location is scheduled to operate through ...
(Date:11/24/2015)... ... November 24, 2015 , ... Cold Shoulder , LLC launched their Pro Vest, the ... and hit their goal of $20,000 in under 10 hours. , The ... new PRO Weight Loss Vest to the market. , The PRO Vest provides consumers with ...
(Date:11/24/2015)... ... November 24, 2015 , ... Sir ... customer service: the TrustDale certification. The award recognizes good companies for excellence in ... , tile and grout, and hard surface restoration company earned this recognition after ...
(Date:11/24/2015)... ... 24, 2015 , ... Dr. Kevin Day, local family chiropractor in Warsaw ... this holiday season. During the Indiana winter months, Vitamin D deficiency can lead ... at AlignLife want to help provide the tools needed to combat it this year! ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015  Array BioPharma Inc. ... Chief Executive Officer, Ron Squarer , will ... in New York.  The public is welcome to ... the Array BioPharma website.Event:Piper Jaffray Annual Healthcare ConferencePresenter:  ... December 2, 2015Time:1:30 p.m. Eastern Time Webcast: ...
(Date:11/24/2015)... and VANCOUVER, Nov. 24, 2015 /PRNewswire/ - ESSA Pharma ... EPIX ) announced today that the first patient has ... EPI-506 as a treatment for metastatic castration-resistant prostate cancer ... and Canada.  --> the United ... In the Phase 1/2 clinical trial, ESSA intends to ...
(Date:11/24/2015)... New York , 24. November 2015 ... des Avery Breathing Pacemaker Systems, ist erfreut, ... als Clinical Consultant bekannt geben zu können. ...   --> Foto ... Stockholm (Schweden). Von 1984-1986 war ...
Breaking Medicine Technology: