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Allegro Diagnostics Announces Publication in Cancer Prevention Research of Prediction Model for Lung Cancer Diagnosis Integrating Clinical and Genomic Features
Date:4/14/2008

Clinicogenomic Model Has Highest Prediction Accuracy for Lung Cancer

BOSTON, April 14 /PRNewswire/ -- Allegro Diagnostics, an emerging leader in the field of molecular diagnostics for lung cancer, has announced publication of a "clinicogenomic" model for lung cancer diagnosis in the inaugural edition of Cancer Prevention Research, the newest journal from the American Association for Cancer Research (AACR), which is devoted exclusively to cancer prevention. The results of the study were published by a multi-disciplinary team from Boston University. The company will be launching a clinical trial in the U.S. and Europe to validate the test featured in the publication.

"Importantly, the clinicogenomic model performs better than either clinical or gene expression factors alone," said Avrum Spira, MD, MSc, a co-author of the study and co-founder of Allegro Diagnostics. "The results also show that the gene expression biomarker, which we published in 2007, is independent from clinical risk factors for disease. The two factors combined thus provide diagnostic synergy."

"One of the important findings from this study is that the clinicogenomic model using Allegro's genetic biomarker performed best in those patients who were considered most difficult to diagnose by a physician panel," said Dan Rippy, President and CEO of Allegro Diagnostics. "Also, given the fairly low detection rate of bronchoscopy for stage I lung cancer at 15 to 20 percent, a clinicogenomic model using our gene expression biomarker has the potential to dramatically increase the rate of detection for early stage disease when it has the greatest likelihood of being cured."

"We believe a diagnostic model that combines a gene biomarker test result with clinical factors can aid physicians in making an earlier diagnosis," said Jerome Brody, MD, Chief Scientific Officer of Allegro Diagnostics. "We are excited about launching a clinical trial to further validate this test, which we
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SOURCE Allegro Diagnostics, Inc.
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