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Allegheny Health Network Team Develops Biomarker for Early Detection of Esophageal Cancer
Date:8/6/2014

l cancer; for identifying and selecting targets for blood testing using a global proteomics profiling platform. The candidate biomarkers were then tested in blood samples from patients with non-Barrett’s esophagus GERD and esophageal cancer. The findings were validated in an independent but similar cohort assembled at Allegheny Health Network and Roswell Park Cancer Institute in Buffalo.

Out of 3,777 identified tissue proteins, five were shown to have significantly elevated levels in blood of patients with esophageal cancer, as compared to those with non-Barrett’s esophagus GERD, and on mathematical modeling four of those five were shown to have predictive value.

Potential future uses for the protein biomarker assay include screening high-risk patients such as those with obesity and GERD, monitoring disease progression from Barrett’s esophagus to high-risk dysplasia to esophageal cancer, tracking a patient’s response to therapy and enabling therapy tailored to a patient’s individual disease biology and detecting recurrence prior to clinical imaging.

“Dr. Jobe’s research shows the value of our approach to working collaboratively and across the full spectrum of disease,” said David Parda, MD, System Chair, Allegheny Health Network Cancer Institute. “This tour de force research integrates clinical work and advanced biology/informatics to improve prevention, treatment, prognostic and predictive capabilities.”

Researchers from the Academic Medical Center in Amsterdam also participated in the study.

Read the full story at http://www.prweb.com/releases/2014/08/prweb12074625.htm.


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