Navigation Links
All-they-can-eat diet for lab mice and rats may foster inaccurate test results
Date:7/18/2012

The widespread practice of allowing laboratory rats and mice to eat as much as they want may be affecting the outcome of experiments in which scientists use these "test-tubes-on-four-feet" to test new drugs and other substances for toxicity and other effects. That's the conclusion of a new analysis published in ACS' journal Chemical Research in Toxicology.

Laboratory mice and rats serve as stand-ins for people for research that cannot be done on humans. In the article, Gale Carey and Lisa Merrill point out that the millions of lab rodents used in laboratory studies each year have a nutritional status that is different from other test animals. While other test animals are fed meals, rodents have round-the-clock access to food. And eat they do, gaining more weight and more body fat than meal-fed rodents. The authors cite other research indicating that lab rodents with free access to food tend to develop abnormally high blood fat levels, high cholesterol, nerve and heart damage, cancer and other disorders.

Their analysis of 54 studies concluded that having free access to food is likely to affect the results of tests for the toxicity and cancer-causing effects of new drugs and other substances in rodents, and could be the reason why such studies have been varying so much in recent years. "Therefore, it is crucial that feeding regimen be carefully considered in designing toxicology experiments," say the authors.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related medicine news :

1. Child abuse and foster care admissions increase when parents use methamphetamines
2. 2 new vitamin D blood tests are often highly inaccurate, researchers say
3. A better way to test new treatments? Approach could help patients and give useful results
4. Green Tea Weight Loss Results and Health Benefits Revealed
5. EVINCI results could lead to 75 percent reduction of invasive procedures for patients with suspected CAD
6. Long-term testosterone treatment for men results in reduced weight and waist size
7. ACP-New York State Chapter partnership results in patient safety organization recognition
8. Tight Blood-Sugar Control Shows Mixed Results for Health of Kidneys: Study
9. Quality of care, other issues may cause worse results in black prostate cancer surgery patients
10. Automated insulin dosage titration system demonstrates positive clinical study results
11. Stem Cell Study Shows Promising Results Against Heart Failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... that proliferation of endogenous neural precursor cells cannot ... axons. From the perspective of neural plasticity, Dr. ... in China observed the effects of functional electrical ... and expression of basic fibroblast growth factor and ... the infarct side. The researchers found that functional ...
(Date:4/22/2014)... FDA-approved device has been shown to reduce seizures in ... percent. When coupled with an innovative electrode placement planning ... the complete elimination of seizures in nearly half of ... trials. , That,s good news for a large portion ... with epilepsy whose seizures can,t be controlled with medications ...
(Date:4/22/2014)... of all lung cancers are small cell lung ... resistance to chemotherapy. However, researchers at Virginia Commonwealth ... into the mechanisms leading to this resistance that ... work primarily by mediating B-cell lymphoma 2 (Bcl-2) ... death. Depending on their function, this family of ...
(Date:4/22/2014)... Working with mice and rabbits, Johns Hopkins scientists have ... and breakdown, successfully preventing the development of atherosclerosis, the ... number-one cause of death among humans. The condition develops ... renders them stiff, narrowed and hardened, greatly reducing their ... and the brain. , In a series of experiments, ...
(Date:4/22/2014)... care spending, a new RAND study concludes that U.S. ... companies and device makers to develop products that produce ... and their use, a new study suggests the study ... get created in the first place. The aim is ... loss of health as possible and to ensure that ...
Breaking Medicine News(10 mins):Health News:Newly approved brain stimulator offers hope for individuals with uncontrolled epilepsy 2Health News:Scientists pinpoint protein that could improve small cell lung cancer therapies 2Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 2Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 3Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 4Health News:US medical innovation needs smarter incentives to cut health spending, study finds 2Health News:US medical innovation needs smarter incentives to cut health spending, study finds 3
... to highlight month long fund raising events to find ... Ted,Strickland has officially declared November as Tay-Sachs Awareness Month,and ... genetic,testing and the need for research to help find ... found most frequently in Ashkenazi Jews, French,Canadians, Louisiana Cajuns, ...
... breakdown, in the epidermis , , FRIDAY, Nov. 2 (Health ... the biological mechanism by which stress increases susceptibility to ... the basis of the stress," said study author Dr. ... of California, San Francisco, and the VA Medical Center, ...
... Institute,s ,Hope Coach, Mobile Mammography Van Features ... Siemens, MAMMOMAT NovationDR Digital System, MALVERN, ... installation of a mobile digital mammography,system in the U.S. ... as part of the Nevada Cancer Institute,s,(NVCI) new Hope ...
... capacity to perceive, comprehend and regulate one,s own emotions and ... between emotions and use this information as a guide for ... developing this type of intelligence is the ability to learn ... changing social and cultural world more effectively. , The Stress ...
... Nov. 2 MedQuist Inc. (Pink,Sheets: MEDQ) announces that ... of strategic alternatives for the Company, is,evaluating whether a ... of the,Company and its shareholders, in light of the ... its decision to proceed,with the sale of its 70% ...
... Limited (ASX: PGL; Nasdaq: PGLA) today announced that ... to PI-88 for the,prevention of tumour recurrence following ... to commence the Phase 3 program as rapidly ... the Special Protocol,Assessment process. The Company has ...
Cached Medicine News:Health News:Governor Strickland Declares November Tay-Sachs Awareness Month 2Health News:Governor Strickland Declares November Tay-Sachs Awareness Month 3Health News:Stress Robs Skin of Antimicrobial Defenses 2Health News:Siemens Rolls Out Its First Mobile Digital Mammography System in the U.S. 2Health News:Siemens Rolls Out Its First Mobile Digital Mammography System in the U.S. 3Health News:Emotional Intelligence and the use of tobacco and cannabis 2Health News:MedQuist Evaluating Whether a Sale of the Company is in the Best Interests of the Company and its Shareholders 2Health News:Progen Update on Phase 3 Clinical Program for PI-88 in Liver Cancer 2Health News:Progen Update on Phase 3 Clinical Program for PI-88 in Liver Cancer 3
(Date:1/14/2014)... 14, 2014 /PRNewswire-iReach/ -- Acumed,s new SLIC Screw System ... accompanying instrumentation to place and insert the screw accurately ... tissue (e.g. ligament) repair or reconstruction as it holds ... (Photo: http://photos.prnewswire.com/prnh/20140114/MN45636 ) The ...
(Date:1/14/2014)... NuAire , a manufacturer of ergonomically designed laboratory equipment ... of Japan to sell and service the ... NuAire will utilize its network of sales professionals throughout ... to offer assistance in application use, product benefits and features, options ...
(Date:1/14/2014)...   Oligomerix, Inc. , a privately held company pioneering ... (AD) and related neurodegenerative disorders, announced today the relocation ... as of January 15, 2014 and expanded ... Medical College. Oligomerix, which is focused on ...
Breaking Medicine Technology:Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3NuAire announces sales and service of Hitachi Koki centrifuges in North America 2Oligomerix Relocates Corporate Headquarters and Secures Additional Laboratory Space from New York Medical College 2
... , WAYNE, Pa., Nov. 20 Escalon Medical Corp. ... quarter ended September 30, 2009. , For the ... or 2.7%, to $8,435,000 during the three-month period ended September ... year. The Company reported the decreased net revenue of ...
... 20 Unilens Vision Inc. (OTC Bulletin Board: UVICF; ... and markets specialty contact lenses, today reported its operating ... (FY2010). , Net sales excluding royalty income, were $1,683,673 ... reported in the previous year first quarter (FY2009). ...
Cached Medicine Technology:Escalon(R) Reports First Quarter Fiscal 2010 Results 2Escalon(R) Reports First Quarter Fiscal 2010 Results 3Escalon(R) Reports First Quarter Fiscal 2010 Results 4Escalon(R) Reports First Quarter Fiscal 2010 Results 5Escalon(R) Reports First Quarter Fiscal 2010 Results 6Escalon(R) Reports First Quarter Fiscal 2010 Results 7Unilens Vision Reports Record First Quarter Earnings and Royalty Income 2Unilens Vision Reports Record First Quarter Earnings and Royalty Income 3Unilens Vision Reports Record First Quarter Earnings and Royalty Income 4
... operation in the cath lab has ... daily clinical routine as cardiologists balance ... and lower costs. With AXIOM Sensis, ... system that helps to master both ...
... Artis dTC is a versatile solution designed ... department from preparation to diagnosis and ... With AXIOM Artis dTC, your cath lab ... department that leaves you free to concentrate ...
... BC is a biplane cardiovascular ... ideal for cardiological diagnostics and ... architecture enables you to optimally ... focus on:, Interventional cardiology, ...
MAGNETOM Symphony, an imaging system that offers 1.5T performance and top image quality in a short bore design....
Medicine Products: