Navigation Links
All in the family: Lower back disease may be in your genes
Date:2/2/2011

Symptomatic lumbar disc disease, a condition caused by degeneration or herniation of the discs of the lower spine, may be inherited, according to a new study published in the Journal of Bone and Joint Surgery (JBJS).

"Previous studies, including studies of twin siblings and subsequent genetic marker studies, have suggested a genetic predisposition for the development of symptomatic lumbar disc disease but have been limited by a small number of patients," noted study author Alpesh A. Patel, MD FACS, assistant professor of orthopaedic surgery at the University of Utah School of Medicine. "The results of this study provide evidence based on a population of more than 2 million people, indicating that there likely is a genetic component in the development of this disease. Additionally, the factors that differentiate a symptomatic disc from a non-painful disc may also be affected by genetics."

Study Details:

  • The researchers used data contained in the Utah Population Database, a public information repository containing health and genealogic data of more than 2 million Utah residents, examining health and family records of 1,264 individuals with lumbar disc disease, defined as either lumbar disc degeneration or lumbar disc herniation.
  • To measure how closely patients were related, the researchers used the Genealogical Index of Familiaity, which compares the average relatedness of affected individuals with expected relatedness in the general population. Relatedness is measured by generations or degrees:
    • first-degree relatives (or immediate family) including parents, offspring and siblings;
    • second-degree including grandchildren, grandparents, uncles, aunts, nieces, nephews, and half-siblings; and
    • third-degree comprising great-grandchildren, great-grandparents, great-aunts and great-uncles, grandnieces and grandnephews and first cousins.
    • In this study, only patients with at least three generations of genealogical data in the database were included.
  • The researchers also determined and calculated the Relative Risk (RR) for relatives. This measure defines the risk of lumbar disc disease among family members of patients compared to individuals without disease. Important Findings:
  • Individuals with lumbar disc disease were more likely to have family members with disc disease.
  • Relative risk for lumbar disc disease was significantly elevated in both close and distant relatives.
  • The combination of the two findings, given the large patient population, strongly supports a genetic basis to symptomatic lumbar disc disease.

"Although excess risk in the immediate family might indicate evidence of a genetic contribution, it could also simply indicate shared environment risks or household exposure that may be contributing to the disease," Dr. Patel noted. "Conversely, excess risks in second and third-degree relatives strongly support a genetic contribution to disease, given the measurable genetic sharing in these more distant relatives and the relative absence of shared household risks."

"There are limitations to our study. We could not measure disease severity or response to treatment. Furthermore, the population of Utah is genetically representative of a US or North European background. As such, this study does not prove a purely genetic basis for disease but suggests that it may play an important role." Dr. Patel noted. "With additional data, this hypothesis can be tested with larger sample sizes."

According to data from the American Academy of Orthopaedic Surgeons (AAOS), back pain is a common problem, and in 2008, attracted more than 12 million physician visits. Dr. Patel said identifying the factors that contribute to the disease can have far-reaching implications.

"Lumbar disc disease is likely due to a number of factors, including mechanical stresses to the spine, age-dependent disc degeneration, biochemical factors and genetics," he said. "This study identified an inheritable predisposition to the development of symptomatic lumbar disc disease and also identified high-risk families in the Utah population, which can be studied to identify genes responsible for this predisposition. Identification of these specific genes may help in the future development of drugs or other interventions to prevent and/or treat lumbar disc disease in the public at large."


'/>"/>

Contact: Lauren Pearson
pearson@aaos.org
847-384-4031
American Academy of Orthopaedic Surgeons
Source:Eurekalert

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Drinking Milk While Pregnant May Lower Kids MS Risk
3. Dark Chocolate May Lower Stroke Risk
4. Can Chocolate Lower Your Risk of Stroke?
5. Chocolate lovers could be lowering their risk of stroke: Study
6. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
7. Olde Towne Gaithersburg Welcomes Thibadeau Mortuary - A Lower-Cost Alternative In Funeral and Cremation Service
8. Prominent New York City Real Estate Investor, Attorney and Atlanta Nursing Home Chains Pay $14 Million to Settle Whistleblower Kickback Case
9. Successful treatment of periodontal disease lowered preterm birth incidences
10. Certain Bone Drugs May Lower Breast Cancer Risk
11. Congressional Concession On Medical Malpractice Awards Will Not Lower Health Care Costs And Will Hurt Patients' Rights, Washington, DC Attorney Says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... 13, 2016 , ... The National Association for Children of ... representing the growing community of recovering individuals (now over 23 million), to issue ... policies addressing addiction. , Although many of the presidential candidates of both ...
(Date:2/13/2016)... FL (PRWEB) , ... February 13, 2016 , ... The ... environmental impact of American businesses. , The increasingly modern world of instantaneous consumption ... often on non-renewable energy sources such as oil and coal, which pollutes our air, ...
(Date:2/13/2016)... ... ... Au Pair comes all the way around the world to provide child care ... often worried things won’t go well. More often than not, however, they find out their ... Year winner’s all commented how their Au Pairs have become a part of the family, ...
(Date:2/12/2016)... ... February 12, 2016 , ... According to an article published ... for a significant portion of hernia repairs throughout the United States. Commenting on this ... Center notes that this trend has not only been expected, but it seems to ...
(Date:2/12/2016)... Seattle, WA, and Washington, DC (PRWEB) , ... ... ... PATH and the Siemens Foundation today announced a new initiative—the Siemens ... technologies for low-resource settings. The partnership will recruit top students from U.S. ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 2016 Indiso ltd ... ungedeckten medizinischen Bedarf bei Lungen- und Atemwegserkrankungen ... Forschungsprogramms bekannt. Das Programm, das sich mit ... respiratorischen Funktionen und anderer klinischer Parameter. ... das sich auf den ungedeckten medizinischen Bedarf ...
(Date:2/11/2016)... - Cardiac Marker Diagnostic ... and Cancer Therapy. - European Point of Care ... - Key Diagnostic Testing Markets. - Molecular ... Genetic Testing. - Molecular Diagnostics in Infectious Disease ... Diagnostic Products World Markets. - Point of Care ...
(Date:2/11/2016)... LONDON , Feb. 11, 2016 Stem ... that are characterized by self-renewal and the capacity to ... a relatively new discovery, as the first mouse embryonic ... it was not until 1995 that the first culturing ... pluripotent stem cells were not produced until 2006 As ...
Breaking Medicine Technology: