Navigation Links
All cancer cells are not created equal
Date:5/15/2012

erentiation revealed distinct populations of RMS cells in the zebrafish model. Cells expressing the progenitor cell marker myf5, were labeled green, and those expressing myogenin, a marker of mature muscle cells, were labeled red.

In a series of experiments, the research team confirmed that myf5-expressing RMS cells had powerful tumor-propagating potential, but the ability to visualize how tumor cells move in living fish produced a surprising observation. While myf5-expressing cells largely remained within the primary tumor itself, myogenin-expressing RMS cells easily moved out from the tumor, entering the vascular system and passing through usually impenetrable layers of collagen. Only after the more-differentiated but non-proliferative myogenin-expressing cells had colonized an area did the myf5-expressing tumor-propagating cells appear and start the growth a new tumor. Imaging the labeled tumor cells also revealed that different cellular populations tended to cluster in different areas of later-stage tumors.

"Our direct in-vivo imaging studies are the first to suggest such diverse cellular functions in solid tumors, based on differentiation and the propensity for self-renewal," says Myron Ignatius, PhD, of MGH Pathology and Center for Cancer Research, the study's first author. "I think we will find that this kind of division of labor is a common theme in cancer, especially given that the vast majority of cells within a tumor are not tumor-propagating cells. We suspect there will be molecularly defined populations that make niches for tumor-propagating cells, secrete factors to recruit vasculature and create boundaries to suppress immune cell invasion."

Langenau adds, "Division of labor is a new and emerging concept in cancer research that we hope will lead to new targets for rationally designed therapies. In rhabdomyosarcoma it will be important to target both the tumor-propagating cells and the highly migratory colonizing c
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. A marker in the lining of the lungs could be useful diagnostic technique for lung cancer screening
2. Video-assisted thoracic surgery valuable tool in lung cancer screening
3. Cancer vaccine combination therapy shows survival benefit in breast cancer
4. Study highlights need for coordination of care in stage 2 and 3 rectal cancer treatment
5. John Theurer Cancer Center hosting 8th Annual Neuro-Oncology Symposium
6. Study examines BI-RADS and MRI in predicting breast cancer
7. Early biomarker for pancreatic cancer identified
8. Fertilizing bone marrow helps answer why some cancers spread to bones
9. Genetic test identifies eye cancer tumors likely to spread
10. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
11. Drug kills cancer cells by restoring faulty tumor suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... The 2015 Crystal Ball, hosted by the Hepatitis B ... and patient advocacy programs. The gala evening included dancing, a ... of supporters. , The 2015 gala was dedicated to the ... (HBV) by Dr. Baruch S. Blumberg, who passed away in ... his discovery of the virus in 1976. He and his ...
(Date:5/5/2015)... May 05, 2015 From the ... the established leader in enabling enterprise collaboration across ... help customers speed up and simplify the move ... AvePoint Solutions for Office 365 enable ... while ensuring sustainable user adoption and effectively managing ...
(Date:5/5/2015)... The newly minted Regan Arts has just released a unique self-help ... from his 20 years working in the field of wilderness therapy. ... a parenting book and why this one, she replied, “What resonates ... it is a journey, not a destination...that the question is not ... together and sometimes not...that each of our struggles is unique. What ...
(Date:5/5/2015)... May 05, 2015 Sunny skies and cool ... Park as nearly 400 runners and walkers participated in Global ... raising nearly $35,000. , The 5K and 10K runs ... Lyme disease and to raise funds for tick-borne disease research. ... by the recent merger of Lyme Research Alliance ...
(Date:5/5/2015)... Nutritional science and medical research has enabled ... health conditions and illnesses linked to carrying excess weight. ... eating methods to rid the body of dangerous toxins, ... fast and processed foods. Patients find the company’s ... report feeling better and losing excess fat within days. ...
Breaking Medicine News(10 mins):Health News:Hepatitis B Foundation Marks 50th Anniversary of HBV Discovery at its Crystal Ball Gala 2Health News:Hepatitis B Foundation Marks 50th Anniversary of HBV Discovery at its Crystal Ball Gala 3Health News:AvePoint Unveils New Solutions for Microsoft Office 365 & Azure at Microsoft Ignite 2015 2Health News:AvePoint Unveils New Solutions for Microsoft Office 365 & Azure at Microsoft Ignite 2015 3Health News:The Last Parenting Book You Will Ever Need: Veteran Publisher Judith Regan Releases A Provocative New Book By Dr. Brad Reedy, "The Journey Of The Heroic Parent" 2Health News:The Last Parenting Book You Will Ever Need: Veteran Publisher Judith Regan Releases A Provocative New Book By Dr. Brad Reedy, "The Journey Of The Heroic Parent" 3Health News:1st Annual “Lyme Walk & Run” Event a Huge Success 2Health News:1st Annual “Lyme Walk & Run” Event a Huge Success 3Health News:Diet Doc Introduces Diet Plans that Teach Patients how to Eat Clean by Getting Back to Basics and Exchanging Processed Foods for Clean, Nutritious Foods 2Health News:Diet Doc Introduces Diet Plans that Teach Patients how to Eat Clean by Getting Back to Basics and Exchanging Processed Foods for Clean, Nutritious Foods 3
... risk factor for cardiovascular diseases.,A potbelly indicates that the risk ... of the body is skinny as a beanpole. ... is the relationship of waist size to the hips, an ... ,The study implies that even people who would otherwise be ...
... Women who exercise by doing household chores like dusting, ... cancer, suggests a new study.// ,The research ... from nine European countries and found that doing housework ... the online edition of BBC News. , ,It ...
... bad habits, is easily acquired but quite difficult to stop.// ... help or at least have to try out recommended smoking ... between the ages of 16 and 24 years do try ... not try out tested methods. ,An article presented ...
... The first woman to undergo a double hand transplant was ... Alba Lucia C, exclaimed "I'm doing very well, I'm very ... through a totally different life. When I saw the hands ... undergo amputation in both her arms following an explosion in ...
... flabby waist certainly points to a greater risk of developing a ... revealed that the risk for coronary illness is inflated to almost ... podgy flabby waistline. ,The diameter along the median sagittal plane ... an imaginary line cutting through the body joining two points from ...
... Janta Party has been inspired from the most unlikely ... planning programme for the Muslim community// based on a ... clerics for awareness campaign as well as the mosque ... way of family planning is ignorance and not religion. ...
Cached Medicine News:Health News:Pot Belly Is A Better Risk Predictor Of Heart Attack Than BMI 2Health News:Tried To Quit Smoking And Failed? Call 1-800-QUIT-NOW 2Health News:Madhya Pradesh Imbibes Family Planning Lessons from Pakistan 2
(Date:5/5/2015)... 2015  Kewaunee Scientific Corporation (NASDAQ: KEQU ) announced ... Kewaunee Scientific,s Board of Directors, effective April 29, 2015. Mr. ... . The election of Mr. Gehl is ... the Board of his intention to resign from the Board, ... Upon his election, Mr. Gehl was also elected chair of ...
(Date:5/5/2015)... , May 05, 2015 Research and ... the addition of the "Clinical Laboratory,Molecular Diagnostics ... 2015 to 2019 - Asia Pacific Version" ... that just keeps on growing. Clinical laboratory testing ... in biotechnology, especially genomics. A range of dynamic ...
(Date:5/5/2015)... Pharmaceuticals, Inc. ("ANI") (NASDAQ: ANIP ) today reported ... 2015 and reaffirmed its revenue, non-GAAP EBITDA, and non-GAAP ... Quarter 2015 Highlights Include: , First quarter net ... to $10.9 million for the same period in 2014. ... an increase of 170% as compared to $4.2 million ...
Breaking Medicine Technology:Keith M. Gehl Elected to Kewaunee Scientific Board of Directors 2Keith M. Gehl Elected to Kewaunee Scientific Board of Directors 3Asia Pacific Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market Report 2015-2019 2ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 2ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 3ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 4ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 5ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 6ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 7ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 8ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 9
... - VASTox plc (AIM: VOX), a leading,UK biotechnology ... of £400,000 by the Welsh Development Agency,(”WDA”) under ... 12 months, will support the research and development,work ... the unique skills and expertise of its scientists,based ...
... 2007 /PRNewswire-USNewswire/ -- The,following statement may be attributed ... Medical Research (CAMR): , "In the face of ... the stroke of his veto pen deliberately to ... well as endanger,the future health and well being ...
Cached Medicine Technology:Vastox Awarded £400,000 Grant to Support R&D at,Carbohydrate Chemistry Facility 2Vastox Awarded £400,000 Grant to Support R&D at,Carbohydrate Chemistry Facility 3President Bush Ignores America's Plea for Support of Stem Cell,Research 2
... The first instrumentation ... efficiently manage the ... Proven technology automatically ... collates cassettes sequentially. ...
Improving on the technology that the world has come to expect from the original SHUR/Mark® Cassette and Slide Labelers, SHUR/Mark® PLUS offers many added enhancements....
Shandon Carousel Cassette MicroWriter™ is a carousel-type cassette marking system....
Modular Slide Storage Cabinet has a durable cold rolled steel construction with baked on epoxy finish. Drawers slide smoothly and quietly....
Medicine Products: