Navigation Links
All cancer cells are not created equal
Date:5/15/2012

A study from Massachusetts General Hospital (MGH) researchers suggests that specific populations of tumor cells have different roles in the process by which tumors make new copies of themselves and grow. In their report in the May 15 issue of Cancer Cell, researchers identify a tumor-propagating cell required for the growth of a pediatric muscle tumor in a zebrafish model and also show that another, more-differentiated tumor cell must first travel to sites of new tumor growth to prepare an environment that supports metastatic growth.

"Most investigators have thought that tumor-propagating cells what are sometimes called cancer stem cells must be the first colonizing cells that travel from the primary tumor to start the process of local invasion and metastasis, but in this model, this is simply not the case," says David Langenau, PhD, of the MGH Department of Pathology and Center for Cancer Research, who led the study. "Instead, the colonizing cells lack the ability to divide and instead prime newly infiltrated regions for the eventual recruitment of slow-moving cancer stem cells. It will be important to test how broadly this phenomenon is found in a diversity of animal and human cancers."

Langenau's team has long been using zebrafish to study rhabdomyosarcoma (RMS), an aggressive pediatric cancer. In embryonic zebrafish, RMS can develop within 10 days, and since the tiny fish are transparent at that stage, fluorescent markers attached to particular cellular proteins can easily be imaged. The current study used these properties to monitor how specific populations of tumor cells develop and their role in initiating new tumor growth.

Previous research from the MGH team had discovered that RMS cells expressing marker proteins also seen on muscle progenitor cells had significantly more tumor-propagating potential than did other tumor cells. Fluorescently labeling proteins associated with different stages of cellular diff
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. A marker in the lining of the lungs could be useful diagnostic technique for lung cancer screening
2. Video-assisted thoracic surgery valuable tool in lung cancer screening
3. Cancer vaccine combination therapy shows survival benefit in breast cancer
4. Study highlights need for coordination of care in stage 2 and 3 rectal cancer treatment
5. John Theurer Cancer Center hosting 8th Annual Neuro-Oncology Symposium
6. Study examines BI-RADS and MRI in predicting breast cancer
7. Early biomarker for pancreatic cancer identified
8. Fertilizing bone marrow helps answer why some cancers spread to bones
9. Genetic test identifies eye cancer tumors likely to spread
10. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
11. Drug kills cancer cells by restoring faulty tumor suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2015)... ... July 28, 2015 , ... ... year, as volunteers celebrate the 14th year of raising money for the Darryl ... downtown Savannah for this year’s main concert Saturday, Oct. 3. , This year’s ...
(Date:7/28/2015)... Morristown, NJ (PRWEB) , ... July 28, 2015 , ... ... hospital in New Jersey, and one of the first five hospitals in the nation, ... implanted in three patients on July 23, and all are in good condition. , ...
(Date:7/28/2015)... ... July 28, 2015 , ... ... the company is in full support of National Immunization Awareness Month, which is ... To stay protected against serious illnesses like the flu, measles, and pneumonia, adults ...
(Date:7/28/2015)... ... July 16, 2015 (PRWEB) July 28, 2015 , ... ... FL, that specializes in providing Health insurance quotes to its clients, recently announced ... auto insurance rates that best suits their specific needs. , Liability automobile ...
(Date:7/28/2015)... ... 2015 , ... opaJUMP! and O-PA! Performance Academy in ... associated with its training methods. This company is also the first to promise ... in early 2015, training yielded an average 80% improvement in functional health status ...
Breaking Medicine News(10 mins):Health News:Worley’s 14th Tennessee River Run Will Host Wade Hayes, Lorrie Morgan, Tracy Lawrence and Others 2Health News:Worley’s 14th Tennessee River Run Will Host Wade Hayes, Lorrie Morgan, Tracy Lawrence and Others 3Health News:Morristown Medical Center First Hospital in New Jersey to Implant Newly Approved Heart Valve 2Health News:Morristown Medical Center First Hospital in New Jersey to Implant Newly Approved Heart Valve 3Health News:CareMed Urgent & Primary Care Supports National Immunization Awareness Month 2Health News:CareMed Urgent & Primary Care Supports National Immunization Awareness Month 3Health News:Nations Insurance Solutions Announces Auto, Motorcycle, and Commercial Business Insurance Quotes. 2Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 2Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 3Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 4Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 5Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 6Health News:opaJUMP Launches First Case Study in Thyroid Health: How Rebounding Helped One Woman Stabilize Her Thyroid in Seven Weeks 7
... urinate in public restrooms followed by a considerable avoidance ... of Anxiety Disorders (available online 8 April ... a form of social phobia. They hypothesized that paruretic ... the severity of paruretic symptoms, not in the severity ...
... There is an increased Gold rush for Bird flu vaccines ... Due to shortage of vaccines for bird flu vaccines the ... to produce Bird flu vaccine. The contract is worth $62.5 ... ,US Health Secretary Mike Leavitt said the move would address ...
... Medical School have identified a possible cause of prostate cancer//, ... or possibly a cure. The study appears in the October ... show a recurring pattern of scrambled chromosomes that leads to ... prostate cancer. ,The researchers found the abnormality in ...
... functioning and schizophrenia, and verbal memory is a ... for real world social functioning. Over the past ... memory are selectively impaired in schizophrenia. ... impairment that may be associated with schizophrenia, researchers ...
... or Lose it' starts three-year lifestyle campaign to fight osteoporosis ... fractures, a new report explains. , ,'One of the ... exercise,' noted Professor Helmut Minne, IOF Board member and author ... build and maintain strong bones, prevent falls and fractures and ...
... avoided by patients with high cholesterol especially in diabetics, ... a egg variety that does no harm to diabetics. ... especially in Indian sub-continent. 'The modified egg is a ... professor in the university's Department of Zoology to IANS., ...
Cached Medicine News:Health News:Shy Bladder Syndrome: A Social Phobia Or Functional Disorder Of Micturition? 2Health News:Prose Memory Deficits Found To Be Associated With Schizophrenia 2Health News:Want Strong Bones: Exercise And Eat Right! 2
(Date:7/28/2015)... July 28, 2015 ANI Pharmaceuticals, Inc. (NASDAQ: ... to release its second quarter and year-to-date 2015 financial ... of the U.S. financial markets. The earnings press release ... the Company,s website, www.anipharmaceuticals.com . ... and Charlotte C. Arnold , Vice President and ...
(Date:7/28/2015)... 28, 2015 Egalet Corporation (Nasdaq: ... company focused on developing, manufacturing and marketing innovative ... underwritten public offering of 6,666,667 shares of its ... $11.25 per share. The gross proceeds to Egalet ... $75 million, before deducting the underwriting discounts and ...
(Date:7/28/2015)... NEW YORK , July 28, 2015 ... releases a new research report with market ... size, share, forecast, porter analysis, recent developments, ... Global Industry Insight: Human Insulin ...      (Logo: http://photos.prnewswire.com/prnh/20150727/756778) ...
Breaking Medicine Technology:ANI Pharmaceuticals Schedules Conference Call for Second Quarter and Year-to-Date 2015 Financial Results 2Egalet Announces Pricing of Public Offering of Common Stock 2Egalet Announces Pricing of Public Offering of Common Stock 3Egalet Announces Pricing of Public Offering of Common Stock 4Global Human Insulin Market (Size of $24 billion in 2014) to Witness 13% CAGR During 2015 - 2020 2Global Human Insulin Market (Size of $24 billion in 2014) to Witness 13% CAGR During 2015 - 2020 3Global Human Insulin Market (Size of $24 billion in 2014) to Witness 13% CAGR During 2015 - 2020 4Global Human Insulin Market (Size of $24 billion in 2014) to Witness 13% CAGR During 2015 - 2020 5
... March 30, 2011 AAIPharma Services Corp., a ... services, has relocated its compendial raw materials testing ... within the company,s Wilmington, N.C., headquarters facility. The ... the company,s core analytical testing business. ...
... 2011 Regado Biosciences, a privately held company pioneering ... announced that David J. Mazzo, PhD, President and CEO, ... Annual Healthcare Conference at the New York Palace Hotel ... at 11:20 a.m. EDT.  The presentation will include an ...
Cached Medicine Technology:AAIPharma Services Announces Compendial Testing Facility Expansion 2Regado Biosciences to Present at the Needham & Company's 10th Annual Healthcare Conference in New York City 2Regado Biosciences to Present at the Needham & Company's 10th Annual Healthcare Conference in New York City 3
Ovarian Cancer Test...
Enzyme Immunoassay for the Quantitative Measurement of Ovarian Cancer Antigen CA-125 in Human Serum...
Abbott offers an array of both in-vitro and molecular diagnostic tests for the detection and monitoring of cancerous conditions in patients....
... neurosurgical OR that fully integrates all ... iMRI, necessary to treat complicated neurosurgical ... are performed in a workflow optimized ... compatibility and safety, BrainSUITE iMRI guarantees ...
Medicine Products: