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Alimera Sciences Signs Second Agreement With Emory University for Potential Treatments Using New Class of Antioxidants
Date:2/26/2008

ATLANTA, Feb. 26 /PRNewswire/ -- Alimera Sciences has entered into a second exclusive worldwide agreement with Emory University to explore oxidative stress management -- specifically the reduction of reactive oxygen species (ROS) -- as a treatment for ophthalmic diseases.

The agreement gives Alimera the exclusive option to license a class of small molecule compounds, known as triphenylmethanes, as a potential treatment for ocular disorders such as diabetic retinopathy and the dry form of age-related macular degeneration (AMD), particularly the late stage of this condition, which is known as geographic atrophy. This agreement is in addition to the September 2007 option to license the NADPH (nicotinamide adenine dinucleotide phosphate reduced form) oxidase inhibitors for similar treatments.

"This second agreement with Emory expands our opportunity to develop expertise in the management of ROS and its damaging effects on the eye," said Dan Myers, President and CEO for Alimera Sciences. "Researching these compounds, as well as the NADPH oxidase inhibitor compounds from our previous agreement with Emory, provides Alimera with an excellent chance of addressing these significant ophthalmic disorders."

Oxidative stress is increasingly being considered as a key aspect in ocular disease development and progression. The increased levels of ROS, which result from oxidative stress, appear to contribute to certain pathologic conditions, including dry AMD. Therefore, reducing ROS levels is becoming an important therapeutic strategy to treat AMD as well as other ophthalmic conditions. While antioxidant compounds attack existing ROS, triphenylmethanes reduce superoxide production and, subsequently, limit the formation of ROS.

If the option is exercised, Alimera will hold an exclusive worldwide license for the triphenylmethanes for ophthalmic indications. Also included in the agreement is an exclusive right to sublicense in ophthalmology and the exc
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SOURCE Alimera Sciences Inc.
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