Navigation Links
Alimera Sciences Signs Second Agreement With Emory University for Potential Treatments Using New Class of Antioxidants

ATLANTA, Feb. 26 /PRNewswire/ -- Alimera Sciences has entered into a second exclusive worldwide agreement with Emory University to explore oxidative stress management -- specifically the reduction of reactive oxygen species (ROS) -- as a treatment for ophthalmic diseases.

The agreement gives Alimera the exclusive option to license a class of small molecule compounds, known as triphenylmethanes, as a potential treatment for ocular disorders such as diabetic retinopathy and the dry form of age-related macular degeneration (AMD), particularly the late stage of this condition, which is known as geographic atrophy. This agreement is in addition to the September 2007 option to license the NADPH (nicotinamide adenine dinucleotide phosphate reduced form) oxidase inhibitors for similar treatments.

"This second agreement with Emory expands our opportunity to develop expertise in the management of ROS and its damaging effects on the eye," said Dan Myers, President and CEO for Alimera Sciences. "Researching these compounds, as well as the NADPH oxidase inhibitor compounds from our previous agreement with Emory, provides Alimera with an excellent chance of addressing these significant ophthalmic disorders."

Oxidative stress is increasingly being considered as a key aspect in ocular disease development and progression. The increased levels of ROS, which result from oxidative stress, appear to contribute to certain pathologic conditions, including dry AMD. Therefore, reducing ROS levels is becoming an important therapeutic strategy to treat AMD as well as other ophthalmic conditions. While antioxidant compounds attack existing ROS, triphenylmethanes reduce superoxide production and, subsequently, limit the formation of ROS.

If the option is exercised, Alimera will hold an exclusive worldwide license for the triphenylmethanes for ophthalmic indications. Also included in the agreement is an exclusive right to sublicense in ophthalmology and the exclusive option for non-ophthalmic use. Alimera will be responsible for both the development and commercialization of the compounds. Emory will receive milestone payments and royalties from net sales.

Emory University, one of the nation's leading private research universities, has focused its highly successful technology transfer program in recent years on achieving proof-of-concept data with its early-stage inventions to make them more attractive to potential business partners. This program of licensing Emory's intellectual property has generated over $650M for the university in the past four years.

"We are pleased to further our relationship with Alimera," said J. Cale Lennon, III, Ph.D., Assistant Director, Office of Technology Transfer, at Emory University. "The addition of the triphenylmethanes will provide Alimera and Emory with a unique class of therapeutic candidates to address the role of oxidative stress in ophthalmic diseases."

Age-Related Macular Degeneration (AMD) is a degenerative eye disease that causes damage to the macula (central retina) of the eye and is the leading cause of blindness for people over the age of 55. AMD affects a person's central vision by causing damage to the macula, the portion of the retina that allows for fine details in vision. AMD manifests itself in two forms, the "wet" form and the more common "dry" form. The "wet" form is caused by the growth of new blood vessels behind the macula. This can cause severe visual loss due to subsequent leakage and creation of scar tissue. Dry AMD accounts for up to 90 percent of all cases of AMD and causes a gradual thinning and loss of function of the macula. There is no drug approved for the treatment of dry AMD at this time.

About Alimera Sciences Inc.

Alimera Sciences Inc., a venture backed company, specializes in the development and commercialization of prescription ophthalmology pharmaceuticals. Founded by an executive team with extensive development and revenue growth expertise, Alimera Sciences' products are focused on improving the delivery of therapeutic agents to enhance patients' lives and strengthen physicians' ability to manage ocular conditions. Alimera has recently completed enrollment of its 956-patient phase III clinical trial of fluocinolone acetonide in the Medidur(TM) drug delivery system for the treatment of diabetic macular edema. For more information, please visit

About Emory University

Emory University is one of the nation's leading private research universities and a member of the Association of American Universities. Known for its demanding academics, outstanding undergraduate college of arts and sciences, highly ranked professional schools, and state-of-the-art research facilities, Emory is ranked as one of the country's top 20 national universities by U.S. News & World Report. In addition to its nine schools, the university encompasses The Carter Center, Yerkes National Primate Research Center and Emory Healthcare, Georgia's largest and most comprehensive health care system. Emory's technology transfer success, in the life sciences area alone, includes eight licensed products with market approval for the treatment of HIV and an additional nine potential therapeutics in various stages of clinical development by its licensees.

SOURCE Alimera Sciences Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. Caliper Life Sciences Reports Fourth Quarter and Full Year 2007 Results
2. Derma Sciences Announces Several Clinical Presentations on MEDIHONEY(TM) Wound & Burn Dressings at Upcoming APWCA Conference
3. Accipiter Life Sciences Announces Nomination of Three Independent Director Candidates for Election to the Penwest Board at the 2008 Annual Meeting
4. Edwards Lifesciences Initiates Patent Infringement Litigation Against CoreValve in the U.S.
5. DARA BioSciences, Inc. and Point Therapeutics, Inc. Announce Consummation of Merger
6. Pennsylvania Gov. Rendell: $10 Million Partnership With Harrisburg Venture Capital Firm Boosts PAs Life Sciences Industry
7. Summary Notice of Proposed Settlement and Settlement Hearing in Re Martek Biosciences Corp., Securities Litigation
8. Edwards Lifesciences Reports Strong Fourth Quarter Sales
9. 7th Annual Wiley Prize in Biomedical Sciences Awarded to Dr. Richard P. Lifton
10. Advanced Life Sciences to Participate in Antibiotics Expert Panel at the 10th Annual BIO CEO & Investor Conference
11. Caliper Life Sciences Ships 500th IVIS Imaging System
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... ... sauna parts and accessories. , Sauna accessories help improve the bather experience in ... personality. From basic styles for the purist looking for simplicity in design to ...
(Date:11/25/2015)... ... 26, 2015 , ... Ministers, senior government and UN agencies, ... Centres of Excellence, and public R&D institutions, civil societies and other partners gathered ... 5th African Network for Drugs and Diagnostics Innovation, ANDI, Stakeholders Meeting. The three- ...
(Date:11/25/2015)... ... November 25, 2015 , ... For the first time, ... Two Organizations, One Beat ” campaign. The partnership between the two groups began in ... in MAP International’s cause. , MAP International was founded in 1954 and is an ...
(Date:11/25/2015)... FL (PRWEB) , ... November 25, 2015 , ... ... center, is encouraging people across the country to celebrate their sobriety and show ... people to post “before and after” photos this Thanksgiving with the hashtag #FacesOfGratitude ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... On November ... training center for the Narconon network, announced the release of a new cutting edge ... the Narconon organization has been working with drug- and alcohol-addicted individuals with the purpose ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , 26 november 2015 ... kondigt de geplande investering aan van ten ... de laboratoria en het mondiale hoofdkantoor in ... uitbreiding zal resulteren in extra kantoorruimte en ... aan de groeiende behoeften van de farmaceutische ...
(Date:11/26/2015)... UTRECHT , Nederland, November 26, 2015 ... --> Een nieuwe aanpak combineert ... van gevorderde kanker. ... -->      (Photo: ... van het Leids Universitair Medisch Centrum (LUMC) ...
(Date:11/26/2015)... 26, 2015 Research and Markets ( ) ... Pacemaker Market Outlook to 2019 - Rise in Cardiac Disorders ... report to their offering. Boston ... Boston scientific and others. --> ... Biotronik, Boston scientific and others. ...
Breaking Medicine Technology: