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Alexza and Biovail Form Collaboration to Develop and Commercialize AZ-004 (Staccato(R) Loxapine) in North America
Date:2/10/2010

age with a stainless steel substrate, onto which a thin film of drug is coated.  When the patient draws a single normal breath through the Staccato device, the substrate surface instantly heats to create an aerosol of optimally-sized, excipient-free particles of drug that are drawn into the patient's lungs. The entire Staccato system actuation and drug delivery occur in less than one second.

The Staccato system is unique among inhalers because it uses no excipients, requires no special breathing maneuvers and there are no controls to deal with.   The system produces a consistently high emitted dose, regardless of the patient's breathing pattern, and doses are pre-set.  About the size of a small cell phone, the unit fits easily in a pocket or purse.

Alexza has screened more than 400 drug compounds and more than 200 drug compounds exhibit initial vaporization feasibility with the Staccato system.  Since the filing of its first IND in 2004, Alexza has dosed more than 2,600 patients and subjects with its Staccato technology, in 22 different clinical trials under six different INDs for Staccato-based product candidates.

Conference Call Information

Alexza will host a conference call Wednesday morning, February 10, 2010, at 8:30 a.m. Eastern Time.  A replay of the call will be available for two weeks following the event.  The conference call and replay are open to all interested parties.  

To access the conference call via the Internet, go to www.alexza.com, under the "Investor Relations" link.  Please join the call at least 15 minutes prior to the star
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SOURCE Alexza Pharmaceuticals, Inc.
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