Navigation Links
Alcoholism's effect on sleep persists during long periods of sobriety

Westchester, Ill. - A study in the Oct.1 issue of the journal Sleep shows that long-term alcoholism affects sleep even after long periods of abstinence, and the pattern of this effect is similar in both men and women.

Results indicate that in long-term alcoholics who had not had a drink for up to 719 days, the percentage of slow wave sleep was significantly lower (6.6% in men, 11.1% in women) than in controls (12.0% in men, 12.1% in women). Alcoholics also had significantly more stage 1 non-rapid eye movement (NREM) sleep (8.5% in men, 6.3% in women) than controls (6.2% in men, 5.6% in women). According to the authors, having less deep, slow wave sleep and more light, stage 1 sleep is reflective of poorer sleep quality, which could act as an exacerbating factor in alcoholics' cognitive decline.

Although women had better sleep efficiency and fewer wake periods than men, no significant interactions between sex and alcoholism diagnosis were found for any measures. This suggests that women show the same general pattern of alcoholism-related sleep changes as men.

Principal investigator Ian Colrain, PhD, director of the SRI International Human Sleep Research Program and a professional fellow in psychology at the University of Melbourne in Australia, also was surprised to find that a significant increase in the percentage of REM sleep persisted in alcoholics who had abstained from drinking for an extended period.

"Previously the REM changes in the acute detox period were assumed to be related to a rebound of the REM suppression effects of alcohol," said Colrain. "The persistence indicates that there is some possibly permanent structural/functional change in REM regulation mechanisms produced by long-term alcohol abuse."

The study involved 42 alcoholics (mean age 49 years, 27 men) who were recruited from an inpatient treatment program and 42 controls (mean age 51 years, 19 men). Estimated lifetime alcohol consumption was significantly higher in male alcoholics (1,607.2 kg) than female alcoholics (843.7 kg). All participants were screened for medical, psychiatric and sleep problems, and their sleep was measured by a full night of polysomnography following an adaptation night. Data were collected from multiple scalp sights and subjected to power spectral analysis. Sleep architecture and electroencephalogram (EEG) spectral power measures were evaluated for the effects of alcoholism diagnosis and sex using age as a covariate.

Results also show that perceived sleep as measured by the Pittsburgh Sleep Quality Index (PSQI) was significantly worse in alcoholics than in controls. Estimated lifetime alcohol consumption was significantly related to the scores on the PSQI in men and women, with higher lifetime consumption predicting less sleep satisfaction. Spectral analysis revealed that alcoholics had significantly reduced levels of slow wave activity during NREM sleep but not during REM sleep, showing that the reduction in slow wave activity in alcoholism is sleep-state specific.

Colrain said that there is a substantial body of literature describing the functional correlates of the structural damage produced by long-term alcohol abuse. Many aspects of psychological functioning are affected by damage to the frontal cortex, including those that relate to judgment and risk taking. He added that there is a growing appreciation for the role of slow wave sleep in supporting memory and other mental functions.


Contact: Kelly Wagner
American Academy of Sleep Medicine

Related medicine news :

1. New treatment effective in counteracting cocaine-induced symptoms
2. Use of certain lipid measures not more effective in predicting coronary heart disease
3. HPV vaccine does not appear to be effective for treating pre-existing HPV infection
4. Effectiveness of mouse breeds that mimic Alzheimers disease symptoms questioned
5. Stanford study highlights cost-effective method of lowering heart disease risks
6. New study may explain Vioxx side-effects
7. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
8. Case Management Cost-Effective Way to Cut Heart Risks
9. ResMed Names Kieran Gallahue as Chief Executive Officer, Effective January 1, 2008.
10. Nasal Anthrax Vaccine Proves Effective in Animal Study
11. Family-based treatment more effective than supportive psychotherapy in treating bulimia
Post Your Comments:
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their ... Award, an essay contest in which patients and their families pay tribute to a ... the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... ... 24, 2016 , ... Puradigm® & Innovative Solutions today announced ... and processing operations at its production facility, and opened its first two dispensaries ... manufacturer of a complete system of proactive air and surface purification solutions for ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) ... held on June 20th at the Woodmont Country Club at 1201 Rockville Pike, ... organization dedicated to helping service members that have been wounded in battle and their ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Capricor ... ), a biotechnology company focused on the discovery, ... that patient enrollment in its ongoing randomized HOPE-Duchenne ... exceeded 50% of its 24-patient target. Capricor expects ... third quarter of 2016, and to report top ...
(Date:6/23/2016)... June 23, 2016 Bracket , a leading ... next generation clinical outcomes platform, Bracket eCOA (SM) 6.0, ... June 26 – 30, 2016 in Philadelphia ... Clinical Outcome Assessment product of its kind to fully integrate ... Bracket eCOA 6.0 is a flexible platform for electronic ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
Breaking Medicine Technology: