Navigation Links
Alcoholics With Cirrhosis Have More Brain Damage
Date:8/28/2007

Genes connected with higher functions are changed by continued abuse, study finds

TUESDAY, Aug. 28 (HealthDay News) -- Alcoholics with cirrhosis (scarring and dysfunction) of the liver have more brain function impairment than other alcoholics, according to new research.

Researchers examined gene expression in the frontal cortex of the brains of seven alcoholics with cirrhosis and 14 alcoholics without cirrhosis.

"We found that the levels of many important brain genes changed in the cirrhotic patients. These genes are important in regulating cell death and how individual cells in the brain talk to each other in a meaningful way," study corresponding author R. Dayne Mayfield, a research scientist at the Waggoner Center for Alcohol and Addiction Research at the University of Texas at Austin, said in a prepared statement.

Out of a total of 1,125 genes, 482 genes showed increased expression, and 643 genes showed decreased expression in the brain tissue of those with cirrhosis.

Mayfield said that the genes examined in this study "are responsible for proper connections and communication between cells in the brain. Without them, normal function would not be possible."

He noted that in people with cirrhosis, the liver is unable to remove poisons from the blood. These poisons can move into the brain and disrupt normal function.

The findings are published in the September issue of the journal Alcoholism: Clinical & Experimental Research.

About 10 percent to 20 percent of heavy drinkers develop cirrhosis, which is the seventh leading cause of death among young and middle-aged adults in the United States. Each year in the United States, 10,000 to 24,000 people die from alcohol-related cirrhosis.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about cirrhosis.



-- Robert Preidt



SOURCE: Alcoholism: Clinical & Experimental Research, news release, Aug. 27, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Alcoholics are prone to disability
2. Role of wives of Alcoholics
3. Sense of smell impaired in alcoholics
4. Antiseizure Drug in help for Alcoholics
5. Cured Alcoholics Can Be Cured Of Smoking Also
6. Children Of Alcoholics Tend to Become Drug Abusers In Adulthood
7. Smoking Cessation Would Be Beneficial For the Recovery of Alcoholics
8. Suicide Attempts Shoot Up Among Alcoholics with Personality Disorder
9. De-addiction Drug Works For Alcoholics Too
10. Alcoholics get Better Treatment from Trained Doctors
11. Marital Therapy Effective Treatment for Female Alcoholics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2017)... ... September 21, 2017 , ... The American ... Health Services for professionals in the addiction treatment industry entitled: Special Investigations ... , Insurance companies and state and federal governments are increasingly scrutinizing the addiction ...
(Date:9/21/2017)... ... 21, 2017 , ... Hair restoration surgery is having a ... the International Society of Hair Restoration Surgery (ISHRS). The worldwide volume ... with 635,189 procedures performed in 2016. , "Like other forms of cosmetic ...
(Date:9/21/2017)... , ... September 21, 2017 , ... Bill Howe Plumbing’s ... its customers, and give back to the community. For over 37 years, they have ... successful companies serving plumbing in San Diego. They were chosen as the ...
(Date:9/21/2017)... ... September 21, 2017 , ... Innovatum ... at the Global GS1 Healthcare Conference 2017 in Chicago, IL on October 17-19, ... ensuring label quality and improving patient safety. , Microscan , a ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... and highly accurate cancer screening tests, has received two prestigious recognitions that acknowledge ... survival rates. , Preora has been named a Top 100 Finalist ...
Breaking Medicine News(10 mins):
(Date:9/9/2017)... , Sept. 8, 2017 Dealmed Medical ... independent supplier of medical equipment, supplies, drugs, vaccines, and ... has entered into an agreement to acquire Vantage Medical ... based in Holtsville, New York . ... in supplying new and emerging medical practices, will operate ...
(Date:9/7/2017)... Sept. 7, 2017 NuvoAir (formerly called ... announced today a partnership with Novartis Pharma AG to distribute ... position as the leading mobile spirometry platform and Novartis, commitment ... ... ...
(Date:9/6/2017)...   PDI , a leader in infection prevention ... educational session focused on the role of chlorhexidine gluconate ... the 2017 Annual Scientific Meeting of the Association for ... the Phoenix Convention Center in ... will also feature PDI,s Prevantics® Device Swab ...
Breaking Medicine Technology: