Navigation Links
Alcoholics' Relapses Better Understood
Date:3/10/2010

Brain mechanism could be key, and an existing drug might help, scientists say

WEDNESDAY, March 10 (HealthDay News) -- U.S. scientists say they've learned new details about molecular mechanisms associated with alcohol addiction and relapse. The findings could lead to new treatments for alcoholism.

The University of California, San Francisco researchers gave lab rats free access to alcohol or sugar for nearly two months, followed by a few weeks of abstinence. The rats who had consumed alcohol, but not those that had consumed sugar, showed increased electrical activity in a part of the brain called the nucleus accumbens (NAcb) core, which plays a role in motivation and goal-directed behaviors.

This increased activity in the NAcb core after abstinence resulted from the inhibition of small-conductance calcium-activated potassium channels (SK).

Futher tests showed that drug-induced activation of SK channels resulted in greater inhibition of NAcb activity in the alcohol-abstinent rats and significantly reduced their desire for alcohol. This type of effect did not occur with sugar-abstinent rats.

The results indicate that decreased SK currents and increased activity in the NAcb core play a critical role in alcoholics' relapse after quitting drinking, said the researchers.

The study appears in the March issue of the journal Neuron.

"Our findings are particularly exciting because the FDA-approved drug chlorzoxazone, which has been used for more than 30 years as a muscle relaxant, can activate SK channels," senior author Dr. Antonello Bonci said in a UCSF news release. "Although SK channels are not the only target of this drug and it can present a variety of clinical side effects, it provides an unexpected and very exciting opportunity to design human clinical trials to examine whether chlorzoxazone, or other SK activators, reduce excessive or pathological alcohol drinking."

More information

The U.S. National Institute on Alcohol Abuse and Alcoholism has more about alcohol problems.



-- Robert Preidt



SOURCE: Cell Press, news release, March 10, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Attendance at Alcoholics Anonymous meetings may reduce depression symptoms
2. Alcoholics May Never Fully Regain Balance
3. New Book Provides Alcoholics with Hope for Stable, Long-Term, Craving-Free Sobriety
4. Researchers find alcoholics display abnormal brain activity when processing facial expressions
5. Public Housing for Homeless Alcoholics Saves Money
6. Iron overload: An important co-factor in the development of liver disease in alcoholics
7. Epilepsy drug may help alcoholics recover from dependence, small study suggests
8. Analysis of alcoholics brains suggests treatment target
9. Focus on Children of Alcoholics at Addiction Agencys Annual Meeting
10. Alcoholics Not to Blame for All Drunk Driving Cases
11. Alcoholics underestimate the risk of bleeding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... CA (PRWEB) , ... May 25, 2016 , ... CloudLIMS, ... Promising Pharma and Life Sciences Tech Solution Providers list of 2016 by CIOReview. , ... Promising Pharma and Life Sciences Tech Solution Providers 2016 has been concluded with. The ...
(Date:5/25/2016)... ... May 25, 2016 , ... The Global Wellness Summit (GWS) ... integrative medical wellness offerings of Europe, a continent that pioneered the medical/wellness concept for ... from numerous pioneers in medical wellness, including Henri Chenot, Founder of the Chenot Group, ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... The University ... Nursing and Health Professions. She will lead a team of more than 100 full-time ... will begin her role as dean in late August. , Baker comes to USF ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... has seen a significant spike in their clients' employee participation for their wellness ... health screening by implementing a high-deductible health plan with outcome-based deductible incentives. As ...
(Date:5/25/2016)... ... ... Stern Environmental Group , of Secaucus, New Jersey, working in conjunction ... Real Time Monitoring (RTM) Device. Stern Environmental Group will sell the first monitoring ... use in dormitories, shelters, and nursing homes for real time bedbug monitoring in May ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... May 23, 2016 Diplomat Pharmacy, Inc. (NYSE: DPLO) ... and Internship programs. The hands-on learning experience is a ... full-time, paid Fellowship and Internship ... . Fellows and interns are provided optional housing free ... at the Riverfront Residence Hall to foster ...
(Date:5/23/2016)... 23, 2016 Clarifying Vision - ... Monitoring, and Vision Care What can be ... going to grow at the fastest rates? This ... assessing data, trends, opportunities and prospects. ... Discover the most lucrative areas in the industry and ...
(Date:5/23/2016)... 23, 2016 Experts from various ... Medicine and the role of technology in innovative ... The First International Conference of VPS-Penn Medicine opened in ... and presence of Sheikh Nahyan bin Mubarak Al Nahyan, Minister ... Medicine, which helps provide personalized medicine and tailor-made healthcare in ...
Breaking Medicine Technology: