Navigation Links
Alcoholic cirrhosis patients had high prevalence of complications at diagnosis

A recent study by Danish researchers discovered patients with alcoholic cirrhosis had a high prevalence of complications at the time of the disease diagnosis. Researchers noted that complications, such as ascites (excessive fluid in the abdomen), were predictors of mortality, but did not develop in a predictable sequence. Results of this 12-year mortality study appear in the May issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases (AASLD).

According to a 2004 report by the World Health Organization (WHO) an estimated 2 billion people worldwide consume alcoholic beverages with 76.3 million of those having alcohol-related disorders. Alcoholic cirrhosis (scarring of the liver) is one such disease, which can occur in 10%-20% of heavy drinkers after many years of frequent drinking. In 2000 the National Institutes of Health (NIH) listed cirrhosis as the 12th leading cause of death and the 4th primary cause of mortality in individuals between 45 and 54 years of age.

The research team led by Peter Jepsen, M.D., identified potential study participants from the Danish Cause of Death Registry, the Danish National Patient Registry, or from the Danish Pathology Registry. The cohort included 466 patients whose medical records indicated cirrhosis was due in part or fully to alcohol abuse, who were diagnosed between January 1, 1993 and August 31, 2005, and who had not previously been examined for suspected cirrhosis. Participants were between the ages of 27 and 84, were 71% male and 79% consumed alcohol.

Results showed that at diagnosis of alcoholic cirrhosis, 24% of patients had no complications, 55% had ascites alone, 6% had variceal bleeding alone, 4% had ascites and variceal bleeding, and 11% had liver encephalopathy (hepatic coma). One-year mortality was 17% among patients with no initial complications, 20% following variceal bleeding alone, 29% following ascites alone, 49% following ascites and variceal bleeding (from the onset of the later of the two complications), and 64% following hepatic encephalopathy. The 5-year mortality ranged from 58% to 85%. After 1 year the risk of complications was approximately 25% and 50% after 5 years for all patients without hepatic encephalopathy.

"Our findings demonstrate that alcoholic cirrhosis patients have a high prevalence of complications at the time of their diagnosis," said Dr. Jepsen. "These complications are strong predictors of 1-year mortality, but not of the risk of developing more complications. Due to the random sequence of complication development the clinical course of alcoholic cirrhosis cannot be determined based on the presence or absence of particular cirrhosis complications," Dr. Jepsen concluded.


Contact: Dawn Peters

Related medicine news :

1. Attendance at Alcoholics Anonymous meetings may reduce depression symptoms
2. Alcoholics May Never Fully Regain Balance
3. Alcoholics Relapses Better Understood
4. Combination Treatment May Help Depressed Alcoholics
5. Targeted therapy prolongs life in patients with HER2-positive breast cancer
6. Aspen Dental Opens 44 New Offices, Welcomes 340,000 New Patients in 2009
7. Blood Thinner Combos Risky for Heart Attack Patients
8. Patients with mild gallstone pancreatitis can undergo surgery sooner, shortening hospital stays
9. Brain Scans Suggest Some Vegetative Patients May Be Aware
10. Inflammation marker related to obesity is elevated in patients with pancreatic cancer
11. Adding Chemo to Tamoxifen Helps Some Breast Cancer Patients
Post Your Comments:
(Date:11/26/2015)... ... 2015 , ... Somu Sivaramakrishnan announced today that he joined ... offers travelers, value and care based Travel Services, including exclusive pricing on a ... cabin upgrades and special amenities such as, shore excursions, discounted fares, travel gifts ...
(Date:11/26/2015)... Aliso Viejo, CA (PRWEB) , ... November 26, ... ... X users a new set of retro-fused, self-animating trailer titles with ProTrailer: Vintage. ... custom style options. These classically-influenced trailer titles work with any font, giving users ...
(Date:11/25/2015)... ... 25, 2015 , ... The holiday season is jam-packed with ... palates of attendees is of the utmost importance. Whether you are cooking at ... these recipes a try this holiday season. , Turkey Croquettes , ...
(Date:11/25/2015)... ... November 26, 2015 , ... Ministers, senior government ... ANDI Pan African Centres of Excellence, and public R&D institutions, civil societies and ... opening of the 5th African Network for Drugs and Diagnostics Innovation, ANDI, Stakeholders ...
(Date:11/25/2015)... , ... November 25, 2015 , ... Dental professionals who ... Cleveland, OH , are invited to attend Dr. Mark Iacobelli’s Advanced Implant Mentoring (AIM) ... in Cleveland, OH. , As the co-founders of Advanced Implant Mentoring (AIM), Dr. ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , 26 november 2015 ... kondigt de geplande investering aan van ten ... de laboratoria en het mondiale hoofdkantoor in ... uitbreiding zal resulteren in extra kantoorruimte en ... aan de groeiende behoeften van de farmaceutische ...
(Date:11/26/2015)... , Nov. 26, 2015 Research and Markets ( ... Pacific Cardiac Pacemaker Market Outlook to 2019 - Rise in ... Demand " report to their offering. ... Boston scientific and others. ... including Medtronic, Biotronik, Boston scientific and ...
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Surface Testing Market: Supplier Shares, Competitive ... offering.  --> ) ... "2016 Future Horizons and Growth Strategies ...
Breaking Medicine Technology: