A study on the effect of different alcoholic beverages and drinking behaviour on the risk of acute pancreatitis was conducted, using the Swedish Mammography Cohort and Cohort of Swedish Men, to study the association between consumption of spirits, wine and beer and the risk of acute pancreatitis.
In total, 84,601 individuals, aged 46-84 years, were followed for a median of 10 years, of whom 513 developed acute pancreatitis. There was a doseresponse association between the amount of spirits consumed on a single occasion and the risk of acute pancreatitis. After multivariable adjustments, there was a 52 per cent (risk ratio 152, 95 per cent confidence interval 112 to 206) increased risk of acute pancreatitis for every increment of five standard drinks of spirits consumed on a single occasion. There was no association between consumption of wine or beer, frequency of alcoholic beverage consumption including spirits, or average total monthly consumption of alcohol (ethanol) and the risk of acute pancreatitis.
Alcohol consumption has often been found to be a risk factor for acute pancreatitis and, as the authors point out, a number of biologic mechanisms for such an association have been suggested. Overall the risk is rather low, as only 1-3% of heavy drinkers develop acute pancreatitis after 10-20 years of follow up. This study evaluated beverage-specific risk among subjects enrolled in a prospectively collected database that included information on the amount of alcohol consumed on a single occasion, frequency of drinking, total alcohol intake, and a number of potential confounders, such as education, data on body weight, smoking, diet, history of diabetes, and history of gall-bladder disease. Very complex and appropriate statistical analytic methods were used.
The study suggests that a greater number of drinks per occasion ("binge drinking") of spirits increases the risk of acute pancreatitis, but no such
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Boston University Medical Center