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Alcohol consumption and polymorphisms of cytochromes P4502E1 are high risks for ESCC
Date:3/13/2008

ype showed a dramatically increased risk of ESCC, which is higher than that due to the respective genotypes.

The susceptibility of alcohol and aldehyde dehydrogenase genotypes on ESCC became evident in 2003 when it became widely accepted that alcoholic beverages are causally related to cancer of the esophagus. A review of case-control studies of the effects of ALDH2 and ADH2 genotypes shows consistently positive associations between inactive heterozygous ALDH2 and the risk for esophageal cancer in East Asian heavy drinkers. Only the ALDH2 genotype has been demonstrated to have a critical role in the development of ESCC.

Using an elegant study design, including 80 male patients with esophageal cancer and 480 controls (age and sex matched), the consumption of alcohol and the genetic polymorphism of enzymes involved in the metabolism of ethanol was examined. This research was performed by doctors from the Laboratory of Gansu College of Traditional Chinese Medicine, Lanzhou, China and from the Laboratory of First hospital of Lanzhou University, Lanzhou, China.


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Contact: Jing Zhu
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

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