Navigation Links
Alcohol consumption and polymorphisms of cytochromes P4502E1 are high risks for ESCC
Date:3/13/2008

Heavier alcohol consumption increases the risk of ESCC. There are synergetic interactions among alcohol drinking and ALDH2, ADH1B, CYP2E1 genotypes. The risk of ESCC in moderate-to-heavy drinkers, ALDH2 (1/2) combined with the ADH1B (1/1) genotype; ALDH2 (1/2) combined with the CYP2E1 (c1/c1) genotype; leads to synergetic interactions, higher than drinkers with ALDH2 (1/1) + ADH1B (1/2 + 2/2); ALDH2 (1/1) + CYP2E1 (c1/c2 + c2/c2).

This study, performed by a team led by Dr. Yan-Mei Guo, is described in a research article published in the March 7, 2008 issue of the World Journal of Gastroenterology.

ESCC is the seventh leading cause of cancer deaths worldwide. Epidemiologic studies have demonstrated that drinking alcoholic beverages is causally related to the development of ESCC. The genetic polymorphisms of Cytochromes P4502E1 (CYP2E1), aldehyde dehydrogenase-2 (ALDH2) and alcohol dehydrogenase-1B (ADH1B; previously called ADH2) affect the metabolism of alcohol. There were some other studies examining the roles of alcohol, CYP2E1, ALDH2 and ADH2 in ESCC. Their findings, however, were contradictory.

In the view of the authors, no clear explanation has, to date, existed to elucidate the susceptibility conferred by CYP2E1, ALDH2 and ADH1B genetic polymorphisms on ESCC. Neither have a definition and evaluation been found to explain the individual and combined roles of these genes and alcohol consumption.

The innovative aspect of this study was the way it looked at the interaction between the CYP2E1, ALDH2 genotype and heavy alcohol drinking, with case-control designs. Previous studies have not examined this issue in detail and to our knowledge this is the first study to show a significant interaction between the CYP2E1, ALDH2 genotype and alcohol drinking. We found there was synergetic interaction with polymorphisms of CYP2E1, ALDH2 genotype and heavy alcohol drinking. Individuals with combined ALDH2 (1/2) and CYP2E1 (c1/c1) genotype showed a dramatically increased risk of ESCC, which is higher than that due to the respective genotypes.

The susceptibility of alcohol and aldehyde dehydrogenase genotypes on ESCC became evident in 2003 when it became widely accepted that alcoholic beverages are causally related to cancer of the esophagus. A review of case-control studies of the effects of ALDH2 and ADH2 genotypes shows consistently positive associations between inactive heterozygous ALDH2 and the risk for esophageal cancer in East Asian heavy drinkers. Only the ALDH2 genotype has been demonstrated to have a critical role in the development of ESCC.

Using an elegant study design, including 80 male patients with esophageal cancer and 480 controls (age and sex matched), the consumption of alcohol and the genetic polymorphism of enzymes involved in the metabolism of ethanol was examined. This research was performed by doctors from the Laboratory of Gansu College of Traditional Chinese Medicine, Lanzhou, China and from the Laboratory of First hospital of Lanzhou University, Lanzhou, China.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. High alcohol consumption increases stroke risk among Chinese men
2. High alcohol consumption increases stroke risk, Tulane study says
3. Alcoholics With Cirrhosis Have More Brain Damage
4. Middle School Marks Most Critical Time to Start Ongoing Conversations About Drug and Alcohol Use With Kids
5. Recovery Resources Collaborates with Two Nonprofit Agencies for Children of Alcoholics Outreach Program
6. Frequent alcohol consumption increases cancer risk in older women
7. Family history of alcoholism affects response to drug used to treat heavy drinking
8. Alcohol and cancer: is drinking the new smoking?
9. Kaiser Permanente study: Alcohol amount, not type -- wine, beer, liquor -- triggers breast cancer
10. Kaiser Permanente Study Shows Alcohol Consumption - No Matter Beverage Type - Linked to Breast Cancer Risk
11. Hands2GO(R) Hand Sanitizer Offers Alcohol-Free Alternative to Stopping the Spread of Flu at School and Work
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... ... Floundering on New Year’s resolutions? Need an excuse to get back on track? ... Apple Association agrees and recommends starting each day with apples, a habit proven ... , The U.S. Apple Association – which represents apple growers and producers nationwide – ...
(Date:1/17/2017)... ... January 17, 2017 , ... In the crowded ... is a stand-out company for several differences from other mainstream brands. , ... demand, this is called 'Agile' manufacturing - http://www.leanproduction.com/agile-manufacturing.html . It allows them ...
(Date:1/17/2017)... ... January 17, 2017 , ... SunView Software’s Service Smart Technology has been selected ... , Each year, Pink Elephant recognizes a new product or service developed ... specific business problem or opportunity. The award highlights original innovations that were released in ...
(Date:1/17/2017)... , ... January 17, 2017 , ... ... well as Palm Desert, is opening a new office in San Clemente, California ... magnetic stimulation (dTMS) in Southern California, successfully treating individuals struggling with major depression. ...
(Date:1/17/2017)... ... January 17, 2017 , ... Surgeons from New York’s fastest ... practitioners on the latest breakthroughs in the prevention, diagnosis and treatment of the ... to eye surgeon, Jeffrey Martin, MD, FACS, Chief Executive Officer of SightMD and ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... China,s National Regulatory Authority Chinese Food and Drug ... Dynavax Flanders Institute Food and Drug Administration ... Gavi Alliance Glaxo Smith Klein ... Service Bureau, Japan Immune Targeting Systems ... Jenner Institute, University of oxford Johnson & Johnson ...
(Date:1/17/2017)... -- Research and Markets has announced the addition of ... to their offering. ... The global artificial pancreas devices system market to grow at ... Artificial Pancreas Devices System Market 2016-2020, has been prepared based on ... covers the market landscape and its growth prospects over the coming ...
(Date:1/17/2017)... Paragon Bioservices received a multiple-award, indefinite-delivery, indefinite-quantity (IDIQ) ... variety of National Institute of Allergy and ... The IDIQ mechanism will allow Paragon to compete ... up to $159 million. Paragon Bioservices, ... of biopharmaceuticals, is one of four awardees to ...
Breaking Medicine Technology: