Navigation Links
Alcohol-breakdown molecule may play a role in breast cancer development
Date:2/11/2014

New research looking at the biological process involved in breast cancer development has strengthened the argument for a potential link between alcohol consumption and the disease.

Scientists from The University of Manchester part of the Manchester Cancer Research Centre and the University of Salford looked at a particular enzyme, a biological molecule that accelerates chemical reactions - known as CYP2E1.

Their findings offer a possible target to improve outcomes for patients in the later stages of the disease.

Dr Costas Demonacos, based at The University's Manchester Pharmacy School who led the research, said: "This enzyme, known as CYP2E1, has been implicated in various liver diseases linked to alcohol consumption (Alcoholic Liver Disease (ALD), as well as diabetes, obesity and cancer.

"We wanted to understand why an enzyme known to function mainly in the liver was found to be heavily present in some types of breast cancer tissues. We also wanted to explore what other activities this enzyme might have that control the development of breast cancer."

The enzyme breaks down various molecules within cells, including alcohol. The by-products of this metabolism include reactive oxygen species (ROS), resulting in something called oxidative stress - in normal physiological conditions this aids cellular functions, whereas when concentrations of ROS are high or oxidative stress becomes chronic, cells can be seriously damaged.

Previous studies have shown that the enzyme is most strongly expressed in early-stage breast tumours rather than more developed tumours and scientists believe that it contributes to the progression of breast cancer. The Manchester team looked at the role it plays in various cellular functions in breast cancer cells.

The study, published in Breast Cancer Research, found that depending on the stage of the breast cancer, high levels of the enzyme can help cells survive during stress.

They also found that inhibiting the activity of the enzyme in cells with high migratory potential promoted cell migration a process linked to cancer spreading known as metastasis.

Dr Demonacos said: "Now that we have a clearer picture of the role played by this enzyme in breast cancer development, scientists could use it as a target in the later stages of the disease, to slow down the spread of cancer as well as to personalise anti-cancer therapy.

"Since CYP2E1 is involved in alcohol metabolism too, our findings should allow new insight on the potential link between chronic alcohol consumption and breast cancer, by showing how alcohol influences the progression of cancer."


'/>"/>

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert

Related medicine news :

1. Molecule movements that make us think
2. Prions in the brain eliminated by homing molecules
3. Researchers identify a life-and-death molecule on chronic leukemia cells
4. Inhibitors of shuttle molecule show promise in acute leukemia
5. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
6. Cleveland Clinic researchers discover molecule that may prevent atherosclerosis
7. Molecule found that inhibits recovery from stroke
8. Molecule shows effectiveness against drug-resistant myeloma
9. Measuring molecules with the naked eye
10. New developments reveal a molecule with a promising function in terms of cancer treatment.
11. Fat molecule ceramide may factor in muscle loss in older adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2017)... ... May 20, 2017 , ... Pot. Reefer. Grass. Mary Jane. No matter what ... its attributes like never before. More than a map, new social marketplace Weedable ... strains, products – and for the first time – each other. A social marketplace ...
(Date:5/21/2017)... ... 2017 , ... Following the tragic and widely publicized death of Rory Staunton, ... that hospitals follow a protocol to quickly identify and treat the condition. , ... steps would have saved Rory or anyone else’s life. , Now, five years ...
(Date:5/19/2017)... (PRWEB) , ... May 19, 2017 , ... ... RawTrition’s BioEnergy in an upcoming episode of Innovations with Ed Begley, Jr., airing ... RawTrition is the distributor of a clean, organic dietary supplement made from naturally ...
(Date:5/19/2017)... ... May 19, 2017 , ... The Miller Agency, a Jacksonville ... and business owners in the region, is embarking on a cooperative charity event ... families. , Multiple sclerosis (MS) is a demyelinating disease that affects the insulation ...
(Date:5/19/2017)... (PRWEB) , ... May 18, 2017 , ... ML Billing, ... of all specialties and sizes and specializes in large group practices, is pleased to ... industry, but it has also set the standard in all aspects of full-service medical ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... 10, 2017 CSSi, the global leader in ... research industry, is proud to announce the launch of ... website features both enriched content and a customized layout ... the company,s already well-established position as the top global ... "After many months of hard work, we are delighted ...
(Date:5/9/2017)... 9, 2017  Oramed Pharmaceuticals Inc. (NASDAQ: ... pharmaceutical company focused on the development of oral ... Intellectual Property Office has granted Oramed a patent ... Exenatide". The patent covers Oramed,s invention of an ... is an incretin hormone that stimulates the secretion ...
(Date:5/8/2017)... 8, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO)., has ... ("WRB"), a health care service center company based in ... specializes in relationship management programs for leading pharmaceutical manufacturers ... WRB will join Envoy Health Management, ... for manufacturers, biotech firms, and other service companies. Together, ...
Breaking Medicine Technology: