Navigation Links
Alcohol-breakdown molecule may play a role in breast cancer development
Date:2/11/2014

New research looking at the biological process involved in breast cancer development has strengthened the argument for a potential link between alcohol consumption and the disease.

Scientists from The University of Manchester part of the Manchester Cancer Research Centre and the University of Salford looked at a particular enzyme, a biological molecule that accelerates chemical reactions - known as CYP2E1.

Their findings offer a possible target to improve outcomes for patients in the later stages of the disease.

Dr Costas Demonacos, based at The University's Manchester Pharmacy School who led the research, said: "This enzyme, known as CYP2E1, has been implicated in various liver diseases linked to alcohol consumption (Alcoholic Liver Disease (ALD), as well as diabetes, obesity and cancer.

"We wanted to understand why an enzyme known to function mainly in the liver was found to be heavily present in some types of breast cancer tissues. We also wanted to explore what other activities this enzyme might have that control the development of breast cancer."

The enzyme breaks down various molecules within cells, including alcohol. The by-products of this metabolism include reactive oxygen species (ROS), resulting in something called oxidative stress - in normal physiological conditions this aids cellular functions, whereas when concentrations of ROS are high or oxidative stress becomes chronic, cells can be seriously damaged.

Previous studies have shown that the enzyme is most strongly expressed in early-stage breast tumours rather than more developed tumours and scientists believe that it contributes to the progression of breast cancer. The Manchester team looked at the role it plays in various cellular functions in breast cancer cells.

The study, published in Breast Cancer Research, found that depending on the stage of the breast cancer, high levels of the enzyme can help cells survive during stress.

They also found that inhibiting the activity of the enzyme in cells with high migratory potential promoted cell migration a process linked to cancer spreading known as metastasis.

Dr Demonacos said: "Now that we have a clearer picture of the role played by this enzyme in breast cancer development, scientists could use it as a target in the later stages of the disease, to slow down the spread of cancer as well as to personalise anti-cancer therapy.

"Since CYP2E1 is involved in alcohol metabolism too, our findings should allow new insight on the potential link between chronic alcohol consumption and breast cancer, by showing how alcohol influences the progression of cancer."


'/>"/>

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert

Related medicine news :

1. Molecule movements that make us think
2. Prions in the brain eliminated by homing molecules
3. Researchers identify a life-and-death molecule on chronic leukemia cells
4. Inhibitors of shuttle molecule show promise in acute leukemia
5. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
6. Cleveland Clinic researchers discover molecule that may prevent atherosclerosis
7. Molecule found that inhibits recovery from stroke
8. Molecule shows effectiveness against drug-resistant myeloma
9. Measuring molecules with the naked eye
10. New developments reveal a molecule with a promising function in terms of cancer treatment.
11. Fat molecule ceramide may factor in muscle loss in older adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... ... 2016 , ... Comfort Keepers® of San Diego, CA is excited to announce ... program to drive cancer patients to and from their cancer treatments. Comfort Keepers ... of life and ongoing independence. Getting to and from medical treatments is one ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
(Date:6/24/2016)... , June 24, 2016  Global Blood Therapeutics, ... company developing novel therapeutics for the treatment of ... announced the closing of its previously announced underwritten ... at the public offering price of $18.75 per ... were offered by GBT. GBT estimates net proceeds ...
(Date:6/24/2016)... The Academy of Managed Care Pharmacy (AMCP) ... would allow biopharmaceutical companies to more easily share health ... and coverage decisions, a move that addresses the growing ... The recommendations address restrictions in the sharing of ... label, a prohibition that hinders decision makers from accessing ...
Breaking Medicine Technology: