Navigation Links
Alcohol Abuse Can Damage Bones
Date:11/6/2008

It interferes with bone metabolism and bone mass maintenance, study finds

THURSDAY, Nov. 6 (HealthDay News) -- Alcohol disrupts genes needed to maintain healthy bones, which can lead to a decrease in bone mass and bone strength, a new study says.

In previous research, the study authors, from Loyola University Stritch School of Medicine in Chicago, showed that giving rats large amounts of alcohol caused significant decreases in bone density and bone strength, but the mechanisms responsible for these effects weren't clear.

In this new study, rats were injected with an amount of alcohol equivalent to binge drinking for three days or chronic alcohol abuse for four weeks in humans. When they examined genes responsible for bone health, the researchers found that alcohol affected the amounts of RNA associated with these genes. RNA acts as the template for making proteins, the building blocks of bones and other tissue.

Alcohol increased the amount of RNA associated with some genes and decreased the amount of RNA associated with other genes. These changes in RNA disrupted two molecular pathways -- the Wnt signaling pathway and the Intergrin signaling pathway -- responsible for normal bone metabolism and bone mass maintenance, the researchers said.

The findings, published recently in the journal Alcoholism: Clinical and Experimental Research, could help in the development of new drugs to minimize bone loss in people who abuse alcohol. Such drugs also might help people at risk for osteoporosis.

"Of course, the best way to prevent alcohol-induced bone loss is to not drink or to drink moderately. But when prevention doesn't work, we need other strategies to limit the damage," study co-author and bone biologist John Callaci, as assistant professor in the department of orthopedic surgery and rehabilitation, said in a Loyola news release.

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about bone health.



-- Robert Preidt



SOURCE: Loyola University, news release, Oct. 23, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Impulse control area in brain affected in teens with genetic vulnerability for alcoholism
2. Malibu Alcohol and Drug Rehab Center Celebrates Fourth Anniversary
3. Alcohol advice needs to play a greater role in sex education for teenagers
4. Pediatricians Could Help Screen for Alcohol Abuse in Home
5. Parents comfortable with alcohol screening in pediatricians offices
6. Severe Health Risks Follow Adults Who Were Diagnosed With Nonalcoholic Fatty Liver Disease as Children
7. PLCB Honors Winners of 2008 Alcohol Awareness Poster Contest
8. Cultures role on alcohol and violence
9. Iowa State study finds moms beliefs may impact their kids alcohol use
10. Children Who Have Frequent Family Dinners Less Likely to Use Marijuana, Tobacco, and Drink Alcohol
11. College Freshmen See Rx Drug Misuse More Risky Than Alcohol, Pot
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... March 23, 2017 , ... Benefits delivery trailblazer, ... app and centralized benefits dashboard solving one of the top frustrations in employee ... For the first time, employees can access up-to-date information and account balances for ...
(Date:3/23/2017)... ... 23, 2017 , ... Hakim Unique Group (HUG) just closed ... Healthcom Group (CHG). , The HUG investment is a landmark move, expanding ... CHG is a growing, internationally recognized healthcare management, technology, and services organization. It ...
(Date:3/23/2017)... Scottsdale, AZ (PRWEB) , ... March 23, 2017 , ... ... helping people around the world to manage stress and anxiety. , “Buzzies change ... Serin, neuropsychologist, inventor and co-founder of Buzzies. , Since its launch date in December ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... of a new solution that enables organizations to easily reprint customer invoices, bills, ... Reprint Server’ automates all of the steps needed to retrieve and print the ...
(Date:3/23/2017)... ... 23, 2017 , ... Altec Products, Inc. , a ... their 2016 Microsoft Dynamics Partner of the Year at DocLink Evolution , ... recognizes The Resource Group for their outstanding relationship with Altec and their ability ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... MUMBAI , March 23, 2017 /PRNewswire/ ... Teil von Piramal Enterprises Limited, gibt die ... Leiter bekannt. PPS bietet seinen globalen Pharmazeutikkunden ... Needleman wird eine wichtige Rolle für das ... spielen. Als kaufmännischer Leiter wird Herr Needleman ...
(Date:3/23/2017)... 23, 2017 /PRNewswire/ - Medicure Inc. ("Medicure" or ... pharmaceutical company, is pleased to announce that its ... from the U.S. Food and Drug Administration (FDA) ... for tetrabenazine tablets in the 12.5 mg and ... a generic equivalent of the branded product Xenazine ...
(Date:3/23/2017)... 2017 The global dermatology devices ... billion by 2025, according to a new report by Grand ... a faster rate due to rising concern amongst people regarding ... of esthetic procedures used for treating hair - and skin-related ... considered as the highest revenue generators for the market. ...
Breaking Medicine Technology: