Navigation Links
Alcohol Abuse Can Damage Bones
Date:11/6/2008

It interferes with bone metabolism and bone mass maintenance, study finds

THURSDAY, Nov. 6 (HealthDay News) -- Alcohol disrupts genes needed to maintain healthy bones, which can lead to a decrease in bone mass and bone strength, a new study says.

In previous research, the study authors, from Loyola University Stritch School of Medicine in Chicago, showed that giving rats large amounts of alcohol caused significant decreases in bone density and bone strength, but the mechanisms responsible for these effects weren't clear.

In this new study, rats were injected with an amount of alcohol equivalent to binge drinking for three days or chronic alcohol abuse for four weeks in humans. When they examined genes responsible for bone health, the researchers found that alcohol affected the amounts of RNA associated with these genes. RNA acts as the template for making proteins, the building blocks of bones and other tissue.

Alcohol increased the amount of RNA associated with some genes and decreased the amount of RNA associated with other genes. These changes in RNA disrupted two molecular pathways -- the Wnt signaling pathway and the Intergrin signaling pathway -- responsible for normal bone metabolism and bone mass maintenance, the researchers said.

The findings, published recently in the journal Alcoholism: Clinical and Experimental Research, could help in the development of new drugs to minimize bone loss in people who abuse alcohol. Such drugs also might help people at risk for osteoporosis.

"Of course, the best way to prevent alcohol-induced bone loss is to not drink or to drink moderately. But when prevention doesn't work, we need other strategies to limit the damage," study co-author and bone biologist John Callaci, as assistant professor in the department of orthopedic surgery and rehabilitation, said in a Loyola news release.

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about bone health.



-- Robert Preidt



SOURCE: Loyola University, news release, Oct. 23, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Impulse control area in brain affected in teens with genetic vulnerability for alcoholism
2. Malibu Alcohol and Drug Rehab Center Celebrates Fourth Anniversary
3. Alcohol advice needs to play a greater role in sex education for teenagers
4. Pediatricians Could Help Screen for Alcohol Abuse in Home
5. Parents comfortable with alcohol screening in pediatricians offices
6. Severe Health Risks Follow Adults Who Were Diagnosed With Nonalcoholic Fatty Liver Disease as Children
7. PLCB Honors Winners of 2008 Alcohol Awareness Poster Contest
8. Cultures role on alcohol and violence
9. Iowa State study finds moms beliefs may impact their kids alcohol use
10. Children Who Have Frequent Family Dinners Less Likely to Use Marijuana, Tobacco, and Drink Alcohol
11. College Freshmen See Rx Drug Misuse More Risky Than Alcohol, Pot
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Ellevate Network, the leading network for professional women, brought together some of ... their inaugural Summit in New York City in June. The event was livestreamed with ... 3 million. To watch the Mobilize Women video, click here . , ...
(Date:10/13/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has ... least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a ... centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: ... “America On The Brink” is the creation of published author, William Nowers. ... As a WWII veteran, he spent thirty years in the Navy. Following ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... now treating sleep apnea using cutting-edge Oventus O2Vent technology. As many ... sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer significant ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 AVACEN Medical , ... company with their  2017 New Product Innovation Award for ... extensive primary and secondary medical device market research by Frost ... its first-to-market OTC, drug-free pain relief product, the AVACEN 100, ... to treating fibromyalgia widespread pain. ...
(Date:10/11/2017)... -- Caris Life Sciences ® , a leading innovator in ... medicine, today announced that St. Jude Medical Center,s Crosson ... as its 17 th member. Through participation with ... Institute will help develop standards of care and best ... cancer treatment more precise and effective. ...
(Date:10/10/2017)... --  West Pharmaceutical Services, Inc. (NYSE: WST), a ... today shared the results of a study highlighting the ... administration of polio vaccines. The study results were presented ... by Dr. Ondrej Mach , Clinical Trials and ... and recently published in the journal Vaccine. i ...
Breaking Medicine Technology: