Navigation Links
Alcohol Abuse Can Damage Bones

It interferes with bone metabolism and bone mass maintenance, study finds

THURSDAY, Nov. 6 (HealthDay News) -- Alcohol disrupts genes needed to maintain healthy bones, which can lead to a decrease in bone mass and bone strength, a new study says.

In previous research, the study authors, from Loyola University Stritch School of Medicine in Chicago, showed that giving rats large amounts of alcohol caused significant decreases in bone density and bone strength, but the mechanisms responsible for these effects weren't clear.

In this new study, rats were injected with an amount of alcohol equivalent to binge drinking for three days or chronic alcohol abuse for four weeks in humans. When they examined genes responsible for bone health, the researchers found that alcohol affected the amounts of RNA associated with these genes. RNA acts as the template for making proteins, the building blocks of bones and other tissue.

Alcohol increased the amount of RNA associated with some genes and decreased the amount of RNA associated with other genes. These changes in RNA disrupted two molecular pathways -- the Wnt signaling pathway and the Intergrin signaling pathway -- responsible for normal bone metabolism and bone mass maintenance, the researchers said.

The findings, published recently in the journal Alcoholism: Clinical and Experimental Research, could help in the development of new drugs to minimize bone loss in people who abuse alcohol. Such drugs also might help people at risk for osteoporosis.

"Of course, the best way to prevent alcohol-induced bone loss is to not drink or to drink moderately. But when prevention doesn't work, we need other strategies to limit the damage," study co-author and bone biologist John Callaci, as assistant professor in the department of orthopedic surgery and rehabilitation, said in a Loyola news release.

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about bone health.

-- Robert Preidt

SOURCE: Loyola University, news release, Oct. 23, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Impulse control area in brain affected in teens with genetic vulnerability for alcoholism
2. Malibu Alcohol and Drug Rehab Center Celebrates Fourth Anniversary
3. Alcohol advice needs to play a greater role in sex education for teenagers
4. Pediatricians Could Help Screen for Alcohol Abuse in Home
5. Parents comfortable with alcohol screening in pediatricians offices
6. Severe Health Risks Follow Adults Who Were Diagnosed With Nonalcoholic Fatty Liver Disease as Children
7. PLCB Honors Winners of 2008 Alcohol Awareness Poster Contest
8. Cultures role on alcohol and violence
9. Iowa State study finds moms beliefs may impact their kids alcohol use
10. Children Who Have Frequent Family Dinners Less Likely to Use Marijuana, Tobacco, and Drink Alcohol
11. College Freshmen See Rx Drug Misuse More Risky Than Alcohol, Pot
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media ... Pro X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice ... X users can now reveal the media of their split screens with growing ...
(Date:6/26/2016)... ... 2016 , ... Quality metrics are proliferating in cancer care, and are derived ... eye of the beholder, according to experts who offered insights and commentary in the ... Care. For the full issue, click here . , For the American Society ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... the Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/24/2016)... ... , ... A recent article published June 14 on E Online ... on to state that individuals are now more comfortable seeking to undergo not only ... calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... 52" report to their offering. ... creates a favourable commercial environment for MedImmune to enter. The ... that will serve to drive considerable growth for effective anti-influenza ... to cap sales considerably, but development is still in its ...
(Date:6/23/2016)... PARK RIDGE, Ill. and INDIANAPOLIS ... caliber of students receiving a Lilly Diabetes Tomorrow,s Leaders ... hands. The 2016 scholarship winners, announced today online at ... refused to let type 1 diabetes stand in the ... Lilly Diabetes has supported the Foundation,s scholarship program since ...
Breaking Medicine Technology: