Navigation Links
'Alarming' Rise Seen in Drug-Resistant Tuberculosis
Date:8/30/2012

THURSDAY, Aug. 30 (HealthDay News) -- There are alarmingly high levels of extensively drug-resistant tuberculosis in many areas of the world, a new study finds.

Researchers found high rates of resistance to at least one second-line drug (nearly 44 percent) among multidrug-resistant TB patients in eight countries in Africa, Asia, Europe and Latin America. They also found higher-than-expected overall levels of extensively drug-resistant TB.

Multidrug-resistant TB can withstand to at least two first-line drugs: soniazid and rifampicin. Extensively drug-resistant TB is resistant to isoniazid, rifampicin, a fluoroquinolone and a second-line injectable drug.

Fluoroquinolones are a class of antibiotics that include ciprofloxacin, levofloxacin and gatifloxacin.

For the study, samples collected from nearly 1,300 adults with multidrug-resistant TB in Estonia, Latvia, Peru, the Philippines, Russia, South Africa, South Korea and Thailand were tested for resistance to 11 first-line and second-line anti-TB drugs. Overall, in nearly 44 percent of patients, resistance to any second-line drug was detected. Rates ranged from 33 percent in Thailand to 62 percent in Latvia.

Overall, one-fifth of patients had resistance to at least one second-line injectable drug, ranging from 2 percent in the Philippines to 47 percent in Latvia. The overall rate of resistance to a fluoroquinolone was nearly 13 percent, ranging from 7 percent in the Philippines to 32 percent in South Korea.

Extensively drug-resistant TB was found in 6.7 percent of patients overall, with prevalence in South Korea (15 percent) and Russia (11 percent) more than twice the current World Health Organization estimate for the same time period (5.4 percent).

The researchers also found that the risk of extensively drug-resistant TB was more than four times higher in patients previously treated for TB, and that previous treatment with second-line drugs was the strongest risk factor for resistance.

The study was published online Aug. 29 in The Lancet.

"Drug-resistant TB is more difficult and costly to treat, and more often fatal. Internationally, it is particularly worrisome in areas with fewer resources and less access to effective therapies. As more individuals are diagnosed with, and treated for, drug-resistant TB, more resistance to second-line drugs is expected to emerge," lead author Tracy Dalton, of the U.S. Centers for Disease Control and Prevention, said in a journal news release.

"So far, [extensively drug-resistant] TB has been reported in 77 countries worldwide, but exact prevalence remains unclear," Dalton noted.

"Most international recommendations for TB control have been developed for [multidrug-resistant] TB prevalence of up to around 5 percent. Yet now we face prevalence up to 10 times higher in some places, where almost half of the patients with infectious disease are transmitting [multidrug-resistant] strains," Sven Hoffner, from the Swedish Institute for Communicable Disease Control, wrote in an accompanying journal editorial.

"Updated information on [multidrug-resistant] TB and investigation of the trends are urgently needed...especially since the true scale of the burden of [multidrug-resistant] and [extensively drug-resistant tuberculosis] might be underestimated and seem to be rapidly increasing," he wrote.

More information

The U.S. Centers for Disease Control and Prevention has more about TB.

-- Robert Preidt

SOURCE: The Lancet, news release, Aug. 29, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. African Chimps Carry Drug-Resistant, Human-Linked Staph
2. Computational analysis identifies drugs to treat drug-resistant breast cancer
3. Scientists develop new strategy to overcome drug-resistant childhood cancer
4. Rare Drug-Resistant Bacteria Spotted in U.S. Hospital
5. New Medicine Might Fight Drug-Resistant TB, Study Says
6. Einstein awarded $6 million grant to develop new TB vaccine against drug-resistant strains
7. Kinase test may yield big gains for drug-resistant cancers
8. Dartmouth medical research closes in on new tuberculosis vaccine
9. Tuberculosis increases the risk of lung cancer mortality in the elderly
10. A better tool to diagnose tuberculosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Alarming' Rise Seen in Drug-Resistant Tuberculosis 
(Date:10/12/2017)... New Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... fitness centers in the U.S., announced today its plans to open a flagship location ... club will occupy the former Rooms To Go store next to Office Depot in ...
(Date:10/12/2017)... , ... October 12, 2017 , ... The American College ... to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in ... , In honor of Morris F. Collen, a pioneer in the field of medical ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Restoration, has recently contributed a medical article to the newly revamped Cosmetic ... Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the ... – Miles by Moonlight to raise money for the American Heart Association Heart Walk. ... , Teams will work together to keep their treadmills moving for 5 hours. Treadmills ...
(Date:10/12/2017)... ... 12, 2017 , ... In the United States, single-family home ... states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average is ... low property-tax rates, which contributes to the relatively lower cost of living in ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today ... Las Piedras, Puerto Rico , where ... Following a comprehensive ... minor structural damage, temporary loss of power and minimal ... completed, manufacturing operations have resumed, and the company expects ...
(Date:10/5/2017)... Oct. 5, 2017  In response to the ... and Maxillofacial Surgeons (AAOMS) released prescribing recommendations that ... be used as a first-line therapy to manage ... Recognizing the value and ... Paper "Opioid Prescribing: Acute and Postoperative Pain Management" ...
(Date:10/2/2017)... Diplomat Pharmacy, Inc. (NYSE: DPLO ... LLC , and named its founder as Diplomat,s chief ... Tennessee , will operate under Diplomat subsidiary ... offerings for health care partners to include IT outsourcing, ... "In an interoperable world, technology delivers comprehensive insight ...
Breaking Medicine Technology: