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Alabama's top cancer center earns $11.5 million renewal of its breast cancer SPORE
Date:10/8/2007

rgery and principal investigator of UABs breast cancer SPORE. Albert LoBuglio, M.D., is the co-principal investigator.

Limited federal funds for cancer research means that NIH-backed projects, particularly SPORE grants, must demonstrate potential for use in patients. "Each of these UAB breast cancer projects have already shown great potential for reducing cancer burden," Bland said.

The grant renewal will fund these four primary projects:

  • Anti-Cancer Antibody Targets DR5. Testing will continue for an experimental anti-cancer agent called TRA-8 in patients whose breast cancer has failed to respond to available therapies. TRA-8 is a monoclonal antibody developed at UAB. Studies show it targets a tumor cell death receptor (DR5) and induces cancer-cell death, while sparing healthy cells. Principal investigators are Tong Zhou, M.D., Albert LoBuglio, M.D. and Donald Buschbaum, Ph.D.
     
  • Retinoids for Chemoprevention. A Phase I clinical trial in humans will examine the experimental compound UAB30 to see if it can prevent breast-cancer recurrence. Developed and patented by UAB scientists years ago, UAB30 is a retinoid, which is a synthetic vitamin A-like compound with proven anti-cancer properties in animals. Other studies will look at retinoids to prevent hormone-resistant breast tumors in animals, or to see if retinoids can prevent and treat other types of cancers. Principal investigators are Donald Muccio, Ph.D., Clinton Grubbs, Ph.D. and Helen Krontiras, M.D.
     
  • KLF4 Cancer Gene Biomarkers. Research is underway to determine if targeting a UAB-discovered cancer gene called KLF4 with drugs can help treat certain aggressive forms of breast cancer. Also, researchers are looking at whether testing for KLF4 genes in breast tissue is a worthwhile predictor for a womans risk of getting cancer. Principal investigators are J. Michael Ruppert, M.D., Ph. D. and Kirby I. Bland, M.D.
     
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Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

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