Navigation Links
Akron researcher awarded NIH grant for advancing 3-D tumor models for anticancer drug testing
Date:10/31/2013

The National Institutes of Health is supporting the work of a University of Akron researcher who may hold the key to improving the effectiveness of cancer treatments. The agency has awarded UA's Hossein Tavana a two-year, $511,000 grant to fund his ongoing efforts to improve the testing and effectiveness of anticancer drugs.

Tavana, an assistant professor of biomedical engineering in the College of Engineering, has developed a method to generate 3-D cultures of cancer cells (spheroids) that better model tumors in the body. These improved models have the potential to dramatically improve the screening and discovery of effective chemotherapeutics, Tavana says.

In support of this novel and promising technology, the NIH awarded Tavana its R21 grant, which is defined by the NIH as a developmental research grant intended to support "exploratory, novel studies that break new ground or extend previous discoveries toward new directions or applications."

Drug testing on 2-D cultures of cancer cells, in which thin layers of cells are treated on a flat dish, does not adequately predict how the drugs will behave in the 3-D environment of the body, Tavana says.

Three-dimensional cultures, on the other hand, in which cancer cells aggregate into spherical clusters, better mimic tumors, allowing for more efficient and cost-effective drug screening and discovery, he adds.

This in turn allows researchers to determine which drugs will best treat particular forms of cancer, eliminating the need to treat patients with a battery of drugs in the hope of finding something that works, Tavana explains.

"Rather than throwing a bunch of different drugs into a patient's body, we can say, 'This particular patient, based on this test, will most likely benefit from this chemo drug.'"

Whereas other labs are generating 3-D cancer cell spheroids, or aggregates, one at a time, Hossein's unique method allows him to generate 384 spheroids "robotically and in a single step," drastically expediting drug testing.

The robot, equipped with rows of pipettes, dispenses cancer cells into 384 small wells, or miniature test tubes, each of which contains a liquid that provides nutrients to the immersed cells, allowing them to aggregate as they would in the body, resulting in 384 physiologic tumor models.

Tavana and his research team are currently testing cell lines cells that have been made immortal so they can be reused over and over of triple negative breast cancer cells and skin cancer. Next year they plan to use primary, patient-derived cells, which will allow them to test drugs under more realistic conditions.


'/>"/>

Contact: Denise Henry
henryd@uakron.edu
330-972-6477
University of Akron
Source:Eurekalert  

Related medicine news :

1. Akron General President & CEO deemed 2013 Wellness Warrior
2. Akron General Health System, Kent State University Form Health and Wellness Research Collaborative
3. CottageCare® Akron Now Offers Patio Cleaning
4. Akron researchers devise Rx for ailing wellness programs
5. UTSA researchers develop prototype football kicking simulator
6. CWRU researchers aim nanotechnology at micrometastases
7. Risk of osteoporosis drugs side effects not significant, Loyola researchers find
8. New look at old test may provide earlier detection of meningitis, MU researchers find
9. MUHC researchers identify biomarkers that could leadto early diagnosis of colorectal cancer
10. Unpublished trial data violates an ethical obligation to study participants, say researchers
11. Einstein researchers lead panels at NIH Aging and Chronic Disease Symposium on Geroscience
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Akron researcher awarded NIH grant for advancing 3-D tumor models for anticancer drug testing
(Date:4/25/2017)... Santa Clara, CA (PRWEB) , ... April 25, ... ... technology, announces the addition of predictive analytics to its patient care management module. ... therapy compliance even before a patient has been initiated on continuous positive airway ...
(Date:4/24/2017)... ... April 24, 2017 , ... Emmanuel College is introducing ... advance their careers. Beginning in the fall of 2017, Emmanuel’s program will allow registered ... few as 16 months and for as little as $14,528. These changes will enable ...
(Date:4/24/2017)... Houston, TX (PRWEB) , ... April 24, 2017 , ... ... Holocaust Memorial Museum today to honor the victims of the Holocaust and Nazi persecution, ... remembrance ceremonies at Hadamar and Auschwitz on its CMATH Champions trip to Germany and ...
(Date:4/24/2017)... ... 24, 2017 , ... Sean Fay is the undisputed king of the infomercial. ... and the George Foreman Grill (which sold more than 100 million units worldwide), he ... years. , Now, due to changes in the broadcast media landscape, the once ever-present ...
(Date:4/24/2017)... ... April 24, 2017 , ... My T Chai, a ... products are now available for purchase on RevNutrition.com, a popular website specializing in sales ... produced and popularized in ancient India and Siam. It spread across Asia and Africa ...
Breaking Medicine News(10 mins):
(Date:4/18/2017)...  Cardinal Health (NYSE: CAH ) today ... per share (EPS) guidance and providing a preliminary view ... with this morning,s announcement of the planned acquisition of ... businesses. Cardinal Health now believes that fiscal ... the bottom of its previous guidance range of $5.35 ...
(Date:4/18/2017)... April 18, 2017 Viverae ® , a ... the integration of IBM ® Watson Campaign Automation, ... targeted communications for a personalized experience. Through digital engagement, ... their health in real time. The enhanced experience drives ... to members, wherever they are in their journey to ...
(Date:4/18/2017)... , April 18, 2017  Astute Medical, Inc., developer ... series to be presented at the 2017 National Kidney ... today and continues through April 22. Physicians will present ... used to assess risk for acute kidney injury (AKI) ... failure (ADHF). Elevated levels of TIMP-2 ...
Breaking Medicine Technology: