Navigation Links
Air pollution primes children for asthma-related cockroach allergy
Date:2/5/2013

An allergic reaction to cockroaches is a major contributor to asthma in urban children, but new research suggests that the insects are just one part of a more complex story. Very early exposure to certain components of air pollution can increase the risk of developing a cockroach allergy by age 7 and children with a common mutation in a gene called GSTM may be especially vulnerable.

Researchers at the Columbia Center for Children's Environmental Health at the Mailman School of Public Health published the findings, the first on this interplay of risk factors, in the February 6 online edition of the Journal of Allergy and Clinical Immunology.

"Allergy to cockroach is one of the greatest risk factors for asthma in low-income urban communities," says lead author Matthew Perzanowski. PhD. "Our findings indicate a complex relationship between allergen and air pollution exposures early in life and a possible underlying genetic susceptibility. Combined, these findings suggest that exposures in the home environment as early as the prenatal period can lead to some children being at much greater risk for developing an allergy to cockroach, which, in turn, heightens their risk of developing asthma."

Dr. Perzanowski and his co-investigators looked at 349 mother-child pairs from the Center's Mothers & Newborns study of environmental exposures in Northern Manhattan and the Bronx. During the mother's pregnancy, exposure to cockroach allergen (protein in feces, saliva or other remnants of the insects) was measured by collecting dust from the kitchen and bed. Researchers also sampled air to measure the mother's exposure to polycyclic aromatic hydrocarbons, or PAH (combustion products that are harmful components of air pollution). Presence of the GSTM1 mutation was determined through blood samples. At ages 5 and 7, the children had blood tests to identify the presence of IgE antibodiesan immune marker of allergy.

The researchers found that 279 or 80% of homes tested positive for high levels of cockroach allergen. By age 7, 82 of 264 children tested, or 31%, had cockroach allergy. Presence of higher levels of cockroach allergen led cockroach allergy only in children whose mothers also had been exposed to higher levels of PAH during pregnancy. This result, the authors say, suggests that PAH enhances the immune response to cockroach allergen.

The combined impact of the two exposures was even greater among the 27% of children with a common mutation in the GSTM gene. This mutation is suspected to alter the ability of the body to detoxify PAHs.

The study suggests that minimizing exposure to PAH during pregnancy and to cockroach allergen during early childhood could be helpful in preventing cockroach allergies and asthma in urban children.

"Asthma among many urban populations in the United States continues to rise," says senior author Rachel Miller, MD. "Identifying these complex associations and acting upon them through better medical surveillance and more appropriate public policy may be very important in curtailing this alarming trend."


'/>"/>

Contact: Timothy S. Paul
tp2111@columbia.edu
212-305-2676
Columbia University's Mailman School of Public Health
Source:Eurekalert

Related medicine news :

1. Maternal exposure to outdoor air pollution associated with low birth weights worldwide
2. Study Sees Possible Link Between Air Pollution and Autism Risk
3. Air pollution, gone with the wind
4. Gestational exposure to urban air pollution linked to vitamin D deficiency in newborns
5. UT Dallas engineers identify material that reduces pollution from diesel engines
6. Using Exhaust Fan on a Gas Stove Cuts Pollution: Study
7. Kitchen exhaust fans vary in effectiveness in reducing indoor air pollution
8. Prenatal exposure to pollution especially dangerous for children with asthma
9. Beijings Olympic Smog Shows Pollutions Effect on Health
10. EPA to Cut Air Pollution from Natural Gas Fracking
11. Record number of children covered by health insurance in 2011
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... ... ... Fresenius Vascular Care, a national network of outpatient vascular care and ambulatory ... range of vascular conditions, has today announced its new name, Azura Vascular Care, as ... than 40 local brands, a phased rollout of the new brand across all locations ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... that the introduction of school choice can promote economic development in economically distressed ... that has, according to the report, contributed to the economic development of the ...
(Date:6/20/2017)... ... ... AMC Health , the leading provider of proven real-time virtual care ... to its approach in demonstrating positive outcomes in the healthcare market, AMC Health has ... of eVisits to support virtual studies. , In a study concluded this ...
(Date:6/20/2017)... ... June 20, 2017 , ... Leading dental clinicians, Drs. Ashlyn ... with the VATECH PaX-i and Anatomage systems. With advanced digital images and modeling capabilities, ... place dental implants precisely and restore oral health for those who are missing ...
(Date:6/20/2017)... ... 20, 2017 , ... As a leading dental practice, Wall Centre Dental supports ... disease. Those with bleeding gums in Vancouver, BC, may be developing gingivitis, the first ... heart disease, stroke and diabetes. Drs. Parviz Roshan, Siamak Tehrani and Milton Reskovich offer ...
Breaking Medicine News(10 mins):
(Date:6/5/2017)... 2017 Kohll,s Pharmacy & Homecare is the first distributor ... States . The Raizer is a simple battery operated ... to an almost-standing position within a few minutes. ... assistant and does not require any extra effort besides ... child can operate it, and lightweight and portable ...
(Date:5/30/2017)... CAESAREA, Israel , May 30, 2017 DarioHealth Corp. ... and big data solutions, today announced that it will be presenting ... 2017, at 8:00 AM PT. Erez Raphael , CEO, of ... The conference will be held on June 6th & 7th, ... 180 companies in the small / micro-cap space. ...
(Date:5/26/2017)... , May 26, 2017  Endo International plc (NASDAQ: ... , President and CEO, will represent the Company in a ... Healthcare Conference on Tuesday, June 13, 2017 at 10:40 a.m. ... at Terranea Resort in Rancho Palos Verdes, CA. ... for the event will be available on the Company,s website ...
Breaking Medicine Technology: